A5021028123- Immune Cell Function and Interaction
- Hops Chemistry and Applications
- Building materials and conservation
- Conservation Techniques and Studies
- Lichen and fungal ecology
- T-cell and B-cell Immunology
- Carcinogens and Genotoxicity Assessment
- Cultural Heritage Materials Analysis
- Neurobiology and Insect Physiology Research
- IL-33, ST2, and ILC Pathways
- Photoreceptor and optogenetics research
- Heavy Metal Exposure and Toxicity
- Circadian rhythm and melatonin
- bioluminescence and chemiluminescence research
- Marine Invertebrate Physiology and Ecology
- Coffee research and impacts
- Nutrition, Genetics, and Disease
- Atherosclerosis and Cardiovascular Diseases
- Powdery Mildew Fungal Diseases
- Zebrafish Biomedical Research Applications
- Genetically Modified Organisms Research
- Pesticide Exposure and Toxicity
- Animal Behavior and Reproduction
- Effects and risks of endocrine disrupting chemicals
- Immunotherapy and Immune Responses
Medical University of Vienna
2016-2025
Institute of Immunology
2024
FH Campus Wien
2022-2024
University of Applied Sciences BFI Vienna
2024
Vienna Biocenter
2019-2021
University of Vienna
2019-2021
Max Perutz Labs
2019-2021
The petroglyphs of the Negev Desert, Israel, are famous and valuable archaeological remains. Previous studies have investigated microbial communities associated with their potential role in stone deterioration; nevertheless, fungi remains unclear. In this study, fungal present on and, as a comparison, surrounding environment (soil air) at petroglyph sites were analyzed by means culture-dependent -independent (metagenomic) techniques. metagenomic results showed high biodiversity soil, both...
Abstract Lung pathogenic T helper type 2 (pTh2) cells are important in mediating allergic asthma, but fundamental questions remain regarding their heterogeneity and epigenetic regulation. Here we investigate immune regulation asthma by single-cell RNA sequencing mice challenged with house dust mite, the presence absence of histone deacetylase 1 (HDAC1) function. Our analyses indicate two distinct highly proinflammatory subsets lung pTh2 pinpoint thymic stromal lymphopoietin (TSLP) Tumour...
Cell lines which are currently used in genotoxicity tests lack enzymes activate/detoxify mutagens. Therefore, rodent-derived liver preparations reflect their metabolism humans only partly; as a consequence misleading results often obtained. Previous findings suggest that certain cell express phase I/II and detect promutagens without activation; however, use is hampered by different shortcomings. The aim of this study was the identification suitable line. sensitivity twelve hepatic...
Abstract Xanthohumol (XN) is a hop flavonoid contained in beers and soft drinks. In vitro animal studies indicated that XN has DNA cancer protective properties. To find out if it causes effects humans, an intervention trial was conducted which the participants (n = 22) consumed containing drink (12 mg XN/P/d). We monitored prevention of damage induced by representatives major groups dietary carcinogens [i.e., nitrosodimethylamine (NDMA) benzo(a)pyrene (B(a)P) heterocyclic aromatic amine...
Salt-weathering is a deterioration mechanism affecting building materials that results from repetitive cycles of salt crystallisation-dissolution in the porous mineral network under changing environmental conditions, causing damage to surfaces. However, an additional biodeterioration phenomenon frequently associated with efflorescence appearance coloured biofilms, comprising halotolerant/halophilic microorganisms, containing carotenoid pigments cause pinkish patinas. In this work, two...
Some epidemiological studies indicate that the use of mobile phones causes cancer in humans (in particular glioblastomas). It is known DNA damage plays a key role malignant transformation; therefore, we investigated impact UMTS signal which widely used telecommunications, on stability ten different human cell lines (six brain derived lines, lymphocytes, fibroblasts, liver and buccal tissue cells) under conditions relevant for users (SAR 0.25 to 1.00 W/kg). We found no evidence induction...
Scope Obesity causes DNA damage, which is causally related to several disorders including cancer, infertility, and cognitive dysfunctions. The aim of this study investigate whether weight loss improves the integrity genetic material. Methods Results Overweight mice are fed ad libitum either with a Western diet (WD), 40% caloric restricted WD, or high carbohydrate low protein (HCLP) diet. Caloric restriction also HCLP lead ca. 30% loss, paralleled by decreased damage (“comet” formation)...
Petroglyph sites exist all over the world. They are one of earliest forms mankind’s expression and a precursor to art. Despite their outstanding value, comprehensive research on conservation preservation rock art is minimal, especially as related biodeterioration. For this reason, main objective study was explore factors involved in degradation petroglyph Negev desert Israel, with focus biodegradation processes. Through use culture-independent microbiological methods (metagenomics), we...
Rhabdomeric opsins (r-opsins) are light sensors in cephalic eye photoreceptors, but also function additional sensory organs. This has prompted questions on the evolutionary relationship of these cell types, and if ancient r-opsins were non-photosensory. A molecular profiling approach marine bristleworm Platynereis dumerilii revealed shared distinct features non-cephalic r-opsin1 -expressing cells. Non-cephalic cells possess a full set phototransduction components, mechanosensory signature....
Results of a number studies indicate that electroplaters have increased cancer risks as consequence exposure to genotoxic metals such chromium (VI) and nickel. These effects may be due induction damage the genetic material which plays key role in etiology cancer, it was found workers galvanization factories exhibited levels DNA damage. The aim present study investigate stability bright plating factory who are exposed (Cr) cobalt (Co). Exfoliated cells were collected from buccal nasal mucosa...
Some of Austria's most important petroglyphs are located in the alpine region Dachstein, carved local limestone. Favored by humid and shady environment, engravings covered extensive biological colonization. In order to assess whether what extent biopatinas present on stone cause biodeterioration, we investigated their interactions with rock substrate microscopy methods (and PAS-staining), combination a metagenomic analysis identify biofilms' composition. The highlighted general...
The marine bristle worm Platynereis dumerilii is a useful functional model system for the study of circadian clock and its interplay with others, e.g., circalunar clocks. focus has so far been on worm's head. However, behavioral physiological cycles in other animals typically arise from coordination clocks located brain peripheral tissues. Here, we rhythms clocks, revisit expand classical work chromatophores, investigate locomotion as read-out include molecular analyses. We establish that...
One of the big challenges in study animal behavior is to combine molecular-level questions functional genetics with meaningful combinations environmental stimuli. Light and temperature are important external cues, influencing behaviors organisms. Thus, understanding combined effect light changes on wild-type vs. genetically modified animals a first step understand role individual genes ability cope changing environments. Many behavioral traits can be extrapolated from tests performed...
Abstract CD8 + T cell exhaustion is a complex process that involves the differentiation of persistently activated cells into functionally distinct subsets. Here, we investigated role key epigenetic regulator histone deacetylase 1 (HDAC1) in exhausted (Tex) during chronic viral infection. We uncovered HDAC1 controls generation and maintenance effector-like CX3CR1 Tex cell-intrinsic manner. Deletion led to expansion an alternative subset characterized by high expression markers, this was...
Fungi have always posed an unquestionable threat to heritage collections worldwide. Now, in a future of climate change, biological risk factors may be considered even more than before. Models and simulations assess possible impacts changing outdoor will on indoor environments and, turn, biodeterioration are still underdeveloped require substantial data basis. This study aimed at filling some these knowledge gaps through broad-based approach combining microclimatic microbiological monitoring...
FOXP3 + regulatory T cells (Treg cells) are key for immune homeostasis. Here, we reveal that nuclear receptor corepressor 1 (NCOR1) controls naïve and effector Treg cell states. Upon NCOR1 deletion in cells, frequencies were elevated mice vitro-generated human cells. NCOR1-deficient failed to protect from severe weight loss intestinal inflammation associated with CD4 transfer colitis, indicating impaired suppressive function. the transcriptional integrity of since gene signatures already...
ABSTRACT Rhabdomeric Opsins (r-Opsins) are light-sensors in cephalic eye photoreceptors, but also function additional sensory organs. This has prompted questions on the evolutionary relationship of these cell types, and if ancient r-Opsins cells were non-photosensory. Our profiling non-cephalic r-opsin1-expressing marine bristleworm Platynereis dumerilii reveals shared distinct features. Non-cephalic possess a full set phototransduction components, mechanosensory signature. We determine that...
<p>Figure S1. Photographic comet images of (1A) undamaged and (1B) damaged nuclei stained with ethidium bromide. Table Statistical analyses data from the participants (n= 22) main study XN containing drink. S2 obtained (n = 10) a pills. Figure S2. Representative histograms γH2AX experiment lymphocytes participant who consumed pills.</p>
<p>Figure S1. Photographic comet images of (1A) undamaged and (1B) damaged nuclei stained with ethidium bromide. Table Statistical analyses data from the participants (n= 22) main study XN containing drink. S2 obtained (n = 10) a pills. Figure S2. Representative histograms γH2AX experiment lymphocytes participant who consumed pills.</p>
Abstract Lung pathogenic T helper type 2 (pTh2) cells are important drivers of allergic asthma, but fundamental questions remain regarding their regulation and heterogeneity. The differentiation effector functions immune tightly regulated by epigenetic processes. Histone deacetylase 1 (HDAC1) is an regulator cells, however, its role in pTh2 yet to be determined. Here we investigate asthma single-cell RNA sequencing (scRNA-seq) mice challenged with house dust mite, the presence absence HDAC1...
<div>Abstract<p>Xanthohumol (XN) is a hop flavonoid contained in beers and soft drinks. <i>In vitro</i> animal studies indicated that XN has DNA cancer protective properties. To find out if it causes effects humans, an intervention trial was conducted which the participants (<i>n</i> = 22) consumed containing drink (12 mg XN/P/d). We monitored prevention of damage induced by representatives major groups dietary carcinogens [i.e., nitrosodimethylamine...
<div>Abstract<p>Xanthohumol (XN) is a hop flavonoid contained in beers and soft drinks. <i>In vitro</i> animal studies indicated that XN has DNA cancer protective properties. To find out if it causes effects humans, an intervention trial was conducted which the participants (<i>n</i> = 22) consumed containing drink (12 mg XN/P/d). We monitored prevention of damage induced by representatives major groups dietary carcinogens [i.e., nitrosodimethylamine...