A5033707180- Neurobiology and Insect Physiology Research
- Photoreceptor and optogenetics research
- Circadian rhythm and melatonin
- Marine Ecology and Invasive Species
- bioluminescence and chemiluminescence research
- Aquatic Ecosystems and Phytoplankton Dynamics
- Spaceflight effects on biology
- Marine Invertebrate Physiology and Ecology
- Heat shock proteins research
- Toxin Mechanisms and Immunotoxins
- Retinal Development and Disorders
- Planarian Biology and Electrostimulation
- Marine animal studies overview
- Computational Drug Discovery Methods
- Marine and coastal ecosystems
- Protein Structure and Dynamics
- Marine and coastal plant biology
- Marine Biology and Environmental Chemistry
- Plant biochemistry and biosynthesis
- Genetics, Aging, and Longevity in Model Organisms
- Developmental Biology and Gene Regulation
Max Perutz Labs
2012-2022
University of Vienna
2012-2022
Vienna Biocenter
2018-2021
Ion Exchange (India)
2012
California Institute of Technology
2012
Indian Institute of Science Bangalore
2009-2012
Research in eye evolution has mostly focused on eyes residing the head. In contrast, noncephalic light sensors are far less understood and rather regarded as evolutionary innovations. We established stable transgenesis annelid Platynereis, a reference species for developmental comparisons. EGFP controlled by cis-regulatory elements of r-opsin, characteristic marker rhabdomeric photoreceptors, faithfully recapitulates known r-opsin expression adult eyes, marks pair pigment-associated...
Abstract Summary: Heat shock protein information resource (HSPIR) is a concerted database of six major heat proteins (HSPs), namely, Hsp70, Hsp40, Hsp60, Hsp90, Hsp100 and small HSP. The HSPs are essential for the survival all living organisms, as they protect conformations on exposure to various stress conditions. They highly conserved group involved in diverse physiological functions, including de novo folding, disaggregation trafficking. Moreover, their critical role control disease...
Ciliary and rhabdomeric photoreceptor cells represent two main lines of photoreceptor-cell evolution in animals. The cell types coexist some animals, however how these functionally integrate is unknown. We used connectomics to map synaptic paths between ciliary photoreceptors the planktonic larva annelid Platynereis found that are presynaptic circuit. behaviors mediated by also interact hierarchically. UV-sensitive mediate downward swimming non-directional UV light, a behavior absent...
Many species synchronize their physiology and behavior to specific hours. It is commonly assumed that sunlight acts as the main entrainment signal for ∼24-h clocks. However, moon provides similarly regular time information. Consistently, a growing number of studies have reported correlations between diel lunidian cycles. Yet, mechanistic insight into possible influences on timers remains scarce. We explored marine bristleworm Platynereis dumerilii investigate role moonlight in timing daily...
The presence of photoreceptive molecules outside the eye is widespread among animals, yet their functions in periphery are less well understood. Marine organisms, such as annelid worms, exhibit a 'shadow reflex', defensive withdrawal behaviour triggered by decrease illumination. Herein, we examine cellular and molecular underpinnings this response, identifying role for photoreceptor molecule Go-opsin class shadow response marine bristle worm Platynereis dumerilii.We found Pdu-Go-opsin1...
Rhabdomeric opsins (r-opsins) are light sensors in cephalic eye photoreceptors, but also function additional sensory organs. This has prompted questions on the evolutionary relationship of these cell types, and if ancient r-opsins were non-photosensory. A molecular profiling approach marine bristleworm Platynereis dumerilii revealed shared distinct features non-cephalic r-opsin1 -expressing cells. Non-cephalic cells possess a full set phototransduction components, mechanosensory signature....
The marine annelid Platynereis dumerilii has become a model system for evo-devo, neurobiology and biology. functional assessment of its cell types, however, so far been very limited. Here we report on the establishment generally applicable, type specific ablation technique to overcome this restriction. Using transgenic strain expressing bacterial enzyme nitroreductase (ntr) under control worm's r-opsin1 locus, show that demarcated photoreceptor cells can be specifically ablated by addition...
Abstract Many species synchronize their physiology and behavior to specific hours. It is commonly assumed that sunlight acts as the main entrainment signal for ~24h clocks. However, moon provides similarly regular time information, increasingly studies report correlations between diel lunidian cycles. Yet, mechanistic insight into possible influences of on ~24hr timers scarce. We studied Platynereis dumerilii uncover moon, besides its role in monthly timing, also schedules exact hour...
Abstract Ciliary and rhabdomeric photoreceptor cells represent two main lines of evolution in animals. The photoreceptor-cell types coexist some animals, however how they functionally integrate is unknown. We used connectomics to map synaptic paths between ciliary photoreceptors the planktonic larva annelid Platynereis found that are presynaptic circuit. behaviors mediated by also interact hierarchically. UV-sensitive mediate downward swimming non-directional UV light, a behavior absent...
ABSTRACT Rhabdomeric Opsins (r-Opsins) are light-sensors in cephalic eye photoreceptors, but also function additional sensory organs. This has prompted questions on the evolutionary relationship of these cell types, and if ancient r-Opsins cells were non-photosensory. Our profiling non-cephalic r-opsin1-expressing marine bristleworm Platynereis dumerilii reveals shared distinct features. Non-cephalic possess a full set phototransduction components, mechanosensory signature. We determine that...