A5070748782- Blood Coagulation and Thrombosis Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Hemophilia Treatment and Research
- Complement system in diseases
- Platelet Disorders and Treatments
- Celiac Disease Research and Management
- Cerebral Venous Sinus Thrombosis
- IL-33, ST2, and ILC Pathways
- Cardiac pacing and defibrillation studies
- Circadian rhythm and melatonin
- Tracheal and airway disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Venous Thromboembolism Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Pregnancy-related medical research
- Colorectal and Anal Carcinomas
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Sports injuries and prevention
- Esophageal and GI Pathology
- Diabetes Management and Research
- Migraine and Headache Studies
- Fatty Acid Research and Health
- Asthma and respiratory diseases
- Colorectal Cancer Treatments and Studies
- Seaweed-derived Bioactive Compounds
Bambino Gesù Children's Hospital
2016-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2021
Azienda ospedaliera "Bianchi-Melacrino-Morelli"
2020
University of Rome Tor Vergata
2016
Alexandria University
2000
Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy caused by severely reduced activity of the von Willebrand factor-cleaving protease ADAMTS13. Over 95% TTPs are acquired, due to autoantibody inhibitors. In children, acquired TTP very rare, life-threatening disease. To date, no consensus exists on treatment strategy pediatric TTP. We report cases two patients with diagnosis TTP, successfully treated combination various therapeutic approaches. Although complained...
Newborns with congenital diaphragmatic hernia (CDH) and esophageal atresia (EA) might experience breastfeeding difficulties. The aim of this study was to detect the prevalence in newborns CDH EA at different time points.We performed an epidemiological retrospective survey on affected newborns. We identified 40 25 who were fed through procedures according WHO categorized definitions, compared beginning hospitalization three months life.Although all mothers attempted after birth, only 44...
We assessed tumour necrosis factor-alpha (TNF-alpha) concentrations in 80 asthmatic children, 26 with severe asthma early-phase reaction, late-phase 28 controlled between attacks oral prednisone and 20 matched control children. TNF-alpha was measured patients' plasma a supernatant of lipopolysaccharide-stimulated (LPS) peripheral blood mononuclear (PBM) cells. the LPS-stimulated cells were positively correlated concentration also time lapse start attack sampling. significantly higher...
Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy caused by severely reduced activity of the von Willebrand factor-cleaving protease ADAMTS13. Over 95% are acquired autoimmune TTP. In children, TTP very rare, life-threatening disease. To date, no consensus exists on treatment strategy pediatric our experience, combined use PEX, Caplacizumab and immunosuppressive therapy during acute phase disease results in prompt persistent normalization laboratory findings...
Inherited factor VII deficiency is the most common rare bleeding disorder, affecting about 1/500,000 individuals without gender predilection. Most of patients with FVII 20–50% are asymptomatic, but post-traumatic or post-surgical may often occur since there not an exact correlation between plasma levels and phenotype. We enrolled 19 children adolescents 20–35% 33 controls. Laboratory data collected included thrombin generation, prothrombin time, activated partial thromboplastin fibrinogen,...
We present a pediatric case of the antiplatelet effect melatonin taken through breast milk in an 18-month-old child. The child was referred to our hematology outpatient clinic because bleeding episodes that she presented since birth. Blood tests excluded presence blood coagulation diseases. family history negative for disorders. did not consume any drugs, food supplements, herbal teas or infusions. performed aggregation platelet test, which showed reduced aggregation. Shortly before, baby...
To test the hypothesis that intensive insulin treatment and optimal glycaemic control are not fully protective against reduction of sensitivity in children with type 1 diabetes.Cohort study 78 normal-weight patients prepubertal onset (T0 ) follow-up waves at (T1 ), 5 (T5 10 (T10 12 (T12 years; matched for age sex to 30 controls T12 . Estimated (eIS) by three formulae; ultrasound evaluation para perirenal fat thickness; hepatic steatosis (HS); carotid intima media thickness (cIMT) .At T12, 36...