A5076182619- Mechanical Circulatory Support Devices
- Hemodynamic Monitoring and Therapy
- Acute Kidney Injury Research
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Optical Imaging and Spectroscopy Techniques
- Non-Invasive Vital Sign Monitoring
- Cardiac and Coronary Surgery Techniques
- Dialysis and Renal Disease Management
- Cardiac Valve Diseases and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Heart Failure Treatment and Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Infective Endocarditis Diagnosis and Management
- Intraoperative Neuromonitoring and Anesthetic Effects
- Organ Transplantation Techniques and Outcomes
- Aortic Disease and Treatment Approaches
- Anesthesia and Sedative Agents
- Cardiac pacing and defibrillation studies
- Blood transfusion and management
- Adrenal Hormones and Disorders
- Transplantation: Methods and Outcomes
Bambino Gesù Children's Hospital
2008-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2022
Boston Children's Hospital
2010-2013
Università Cattolica del Sacro Cuore
2010
We determined if low dose fenoldopam in neonates already receiving conventional diuretics improves urine output, fluid balance, acute kidney injury incidence (AKI) and time to extubation. A prospective controlled clinical trial a pediatric cardiac intensive care unit on 40 undergoing surgery with cardiopulmonary bypass, excluding simple ventricular septal defect atrial defect. Fenoldopam was infused at of 0.1 microg/kg/min soon after anesthesia induction infusion prolonged for 72 h 20...
To investigate the correlation between cerebral near-infrared spectroscopy (NIRS) (rSO2c) and superior vena cava venous oxygen saturation (ScvO2) in newborn patients with congenital heart disease (CHD).NIRS is a noninvasive method to monitor hemoglobin using nonpulsatile oximetry.We retrospectively analyzed perioperative data from 100 who underwent cardiac surgery for CHD. rSO2c, ScvO2 24 h before 72 after were recorded.rSO2c had fair (r 0.37; P <0.001). The relationship rSO2c did not change...
The acute renal failure (ARF) incidence in pediatric cardiac surgery intensive care unit (ICU) ranges from 5 to 20% of patients. In particular, clinical features neonatal ARF are mostly represented by fluid retention, anasarca and only slight creatinine increase; this is the reason why medical strategies prevent manage have limited efficacy early optimization replacement therapy (RRT) plays a key role outcome cardiopathic patients.Data on neonates admitted our ICU were prospectively...
We describe the impact of cardiovascular pharmacologic support on peritoneal dialysis adequacy in 20 neonates who required postoperative renal replacement therapy following cardiopulmonary bypass exposure. Peritoneal was administered for 2.5 (2) days. creatinine clearance 3.4 (2.1) ml/min/1.73 m(2) and ultrafiltration rate 9.75 (10) ml/h. Residual 31 (26) m(2). appeared to be a function dialysate flow up 100 No correlation present between inotropes vasopressors infusion...
The aim of this study was to identify the predictors death and reintervention after mitral valve replacement (MVR) in children.A single-centre retrospective performed including 115 patients under age 18 undergoing MVR between 1982 2019. For all patients, ratio prosthetic size (diameter mm) weight (kg) at surgery calculated long-term result assessed. primary outcome freedom from (MV) re-replacement. composite secondary or transplant.Fifty-four had a previous surgical attempt MV repair. median...
The incidence of anaphylactic reactions during anesthesia is between 1:5000 and 1:25000 it one the few causes mortality directly related to general anesthesia. most important requirements in treatment this clinical condition are early diagnosis maintenance vital organ perfusion. Epinephrine administration generally considered as first line reactions. However, recently, new pharmacological approaches have been described different forms vasoplegic shock.We describe case a child who was...
Objective To report a case of newborn patient with renal failure due to polycystic kidneys requiring replacement therapy, and total anomalous pulmonary venous return major cardiosurgical intervention. Setting Pediatric cardiosurgery operatory room pediatric cardiologic intensive care. Patient: A 6-day-old child weighing 3.1 kg. Results Renal function (creatinine value urine output) was monitored during the course operation intraoperative therapy not initiated. Serum creatinine concentration...
To report the successful application of neurally adjusted ventilatory assist to a child with cystic fibrosis who underwent single-lung transplantation.Case report.Pediatric cardiac intensive care unit.A 15-yr-old male was admitted our pediatric unit after transplantation. The had previously received two bowel resections at age 1 yr, right pneumonectomy 3 yrs, and endoscopic percutaneus gastrostomy 10 yrs. After transplant, failed several attempts weaning off mechanical ventilation...
The aim of this study was to evaluate the safety and efficacy levosimendan, a novel calcium sensitizer agent, on postoperative hemodynamic metabolic parameters neonates affected by single ventricle anatomy. Twenty consecutive scheduled for Norwood procedure with Blalock Taussig shunt were prospectively enrolled. All patients received an infusion levosimendan at 0.1 μg/kg/min commencing 24 hours before surgery, continued 48 after surgery. No side effects (intolerance drug, hypotension,...
The complex hemostatic changes associated with Berlin Heart (BH) implantation in children require a challenging antithrombotic treatment. aim of this retrospective analysis was to evaluate the thromboelastography (TEG)-platelet mapping (PM) assay monitor antiplatelet therapy implanted BH.TEG-PM performed 4 BH-implanted patients receiving dipyridamole and aspirin, 9 healthy volunteers. Patients' adjusted TEG-PM results. Light transmission aggregometry (LTA) also available for 2 these...
The aim of this study was to elucidate predictors death and reintervention after mitral valve (MV) surgery in children.A single-centre retrospective performed enrolling 142 patients younger than 18 years who underwent primary index surgical repair or replacement at Bambino Gesù Children's Hospital Rome from July 1982 April 2020. Patients with complete, transitional partial atrioventricular septal defect single ventricle physiology were excluded. stratified according the age group: group 1...
Inherited factor VII deficiency is the most common rare bleeding disorder, affecting about 1/500,000 individuals without gender predilection. Most of patients with FVII 20–50% are asymptomatic, but post-traumatic or post-surgical may often occur since there not an exact correlation between plasma levels and phenotype. We enrolled 19 children adolescents 20–35% 33 controls. Laboratory data collected included thrombin generation, prothrombin time, activated partial thromboplastin fibrinogen,...
Background: Available data about pharmacokinetics (PK) of antimicrobials administered as surgical prophylaxis to children undergoing cardiac surgery with cardiopulmonary bypass (CPB) showed that drug concentrations during CPB may be supra or subtherapeutic. The aim this study was determine the population PK and pharmacodynamic target attainment (PTA) cefoxitin pediatric surgery. Methods: A prospective interventional conducted. Cefoxitin (40 mg/kg, up max 1000 mg) before skin incision. Blood...