A5007823952- BRCA gene mutations in cancer
- Genomics and Rare Diseases
- Nutrition, Genetics, and Disease
- Health, Environment, Cognitive Aging
- Genetic Associations and Epidemiology
- Ethics in Clinical Research
- Folate and B Vitamins Research
- Cancer Genomics and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Prenatal Screening and Diagnostics
- Genetic factors in colorectal cancer
- Genetics, Bioinformatics, and Biomedical Research
- Global Cancer Incidence and Screening
- Birth, Development, and Health
- Congenital Anomalies and Fetal Surgery
- Health and Medical Research Impacts
- Epigenetics and DNA Methylation
- Iron Metabolism and Disorders
- Biomedical Text Mining and Ontologies
- Health Policy Implementation Science
- Esophageal and GI Pathology
- Congenital Heart Disease Studies
- Hemoglobinopathies and Related Disorders
- Lipoproteins and Cardiovascular Health
- Bioinformatics and Genomic Networks
Office of Public Health Genomics
2016-2025
Centers for Disease Control and Prevention
2016-2025
National Center on Birth Defects and Developmental Disabilities
1993-2025
Office of Science
2020-2023
National Cancer Institute
2008-2018
Center for Surveillance, Epidemiology, and Laboratory Services
2015-2018
The Centers
2018
Boston University
2017
National Institutes of Health
2008-2016
Kajaani University of Applied Sciences
2012-2014
To address the vast gap between current knowledge and practice in area of dissemination implementation research, we terminology, provide examples successful applications this discuss key sources support, highlight directions opportunities for future advances. There is a need research testing approaches to scaling up sustaining effective interventions, propose that further advances field will be achieved by focusing on 5 core values: rigor relevance, efficiency, collaboration, improved...
Although the excess risk for birth defects among children of mothers with diabetes mellitus is well documented, there are few data concerning specific malformations. In Atlanta Birth Defects Case-Control Study, those risks malformations were evaluated. The population-based study included 4929 live and stillborn babies major ascertained by Metropolitan Congenital Program in first year life born to residents between 1968 1980. also 3029 nonmalformed who frequency-matched case race, period...
We present a potentially useful alternative approach based on support vector machine (SVM) techniques to classify persons with and without common diseases. illustrate the method detect diabetes pre-diabetes in cross-sectional representative sample of U.S. population.We used data from 1999-2004 National Health Nutrition Examination Survey (NHANES) develop validate SVM models for two classification schemes: Classification Scheme I (diagnosed or undiagnosed vs. no diabetes) II (undiagnosed...
Several epidemiologic studies suggested that higher sodium and lower potassium intakes were associated with increased risk of cardiovascular diseases (CVD). Few have examined joint effects dietary intake on mortality.To investigate estimated usual as well their ratio in relation to all-cause CVD mortality, the Third National Health Nutrition Examination Survey Linked Mortality File (1988-2006), a prospective cohort study nationally representative sample 12,267 US adults, studied all-cause,...
Human well-being could benefit from large-scale data if noise is minimized
Interview with Muin Khoury on personal genomics services being offered directly to consumers. (06:45)Download It may happen soon. A patient, perhaps one you have known for years, who is overweight and does not exercise regularly, shows up in your office an analysis of his whole genome at multiple single-nucleotide polymorphisms (SNPs). His children, were concerned about health, spent $1,000 give him the as a holiday gift. The test report states that genomic profile consistent increased risk...
While the authors agree with John Ioannidis that "most research findings are false," here they show replication of enhances positive predictive value being true.
Our website uses cookies to enhance your experience. By continuing use our site, or clicking "Continue," you are agreeing Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications Network Open Cardiology Dermatology Health Forum Internal Medicine Neurology Oncology Ophthalmology Otolaryngology–Head & Neck Surgery Pediatrics Psychiatry Archives of (1919-1959) JN Learning /...
This Viewpoint discusses differing opinions on whether precision medicine can help improve US population health and if so, potential approaches to implementing a coordinated effective effort between the medical public communities.
Using the population-based data from Metropolitan Atlanta Congenital Defects Program, interrelation of six defects that are components VACTERL association were investigated. There 400 cases with two or more these defects, whereas only 29 would be expected if had occurred together randomly. 76 three less than one case was expected. Of cases, seven recognized causes (five chromosomal anomalies, single-gene disorders); another 19 clinical phenotypes syndromes unknown etiology. In remaining 50...
Bridging the gap between gene discovery and our ability to use genetic information benefit health requires population-based knowledge about contribution of common variants gene-environment interactions risk disease. The risks benefits associated with research involving genetics, especially lower-penetrance variants, can differ in nature from those family-based research. In response urgent need for appropriate guidelines, Centers Disease Control Prevention formed a multidisciplinary group...
The relationship between congenital malformations and intrauterine growth retardation was investigated using data from the population-based Metropolitan Atlanta Congenital Defects Program. Between 1970 1984, system ascertained 13,074 infants with major structural diagnosed in first year of life born to metropolitan residents. These were classified as having if their birth weight below race-, sex-, gestational age-specific tenth percentile limits for all births. Overall, frequency among...