A5032924560- RNA and protein synthesis mechanisms
- Electrochemical sensors and biosensors
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Chemical Synthesis and Analysis
- Biosensors and Analytical Detection
- DNA and Nucleic Acid Chemistry
- Click Chemistry and Applications
- Electrochemical Analysis and Applications
- Advanced Proteomics Techniques and Applications
- Biotin and Related Studies
- Viral Infectious Diseases and Gene Expression in Insects
- RNA modifications and cancer
- Photochromic and Fluorescence Chemistry
Srinakharinwirot University
2022-2024
University of Pennsylvania
2017-2019
California University of Pennsylvania
2017
Philadelphia University
2017
We report the selection and characterization of an improved acridon-2-ylalanine aminoacyl tRNA synthetase.
Improvements in genetic code expansion have made preparing proteins with diverse functional groups almost routine. Nonetheless, unnatural amino acids (Uaas) pose theoretical burdens on protein solubility, and determinants of position-specific tolerability to Uaas remain underexplored. To broadly examine associations, we systematically assessed the effect substituting fluorescent Uaa, acridonylalanine, at more than 50 chemically, evolutionarily, structurally residues two bacterial proteins:...
A combination of labeling techniques enables site-specific installation fluorescent probes for measuring distances within proteins by Förster resonance energy transfer (FRET).
Acridonylalanine (Acd) is a useful fluorophore for studying proteins by fluorescence spectroscopy, but it can potentially be improved being made longer wavelength or brighter. Here, we report the synthesis of Acd core derivatives and their photophysical characterization. We also performed ab initio calculations absorption emission spectra derivatives, which agree well with experimental measurements. The amino acid aminoacridonylalanine (Aad) was synthesized in forms appropriate genetic...
Abstract This study describes the development of a simple, reliable, and low‐cost method to rapidly detect Mn 2+ based on co‐functionalized silver nanoparticles (AgNPs) smartphone platform be applied as an on‐site device in field. The AgNPs was investigated with other cations (Al 3+ , Ba Ca Cd Co Cr Cu Fe K + Li Mg Na Ni Pb Zn ) at pH 3–10. results showed that this functionalized selectively binded 10, which caused color solution changing from yellow orange‐red can measured by application...
This study describes the development of a simple, reliable, and low-cost method to rapidly detect Mn2+ based on co-functionalized silver nanoparticles (AgNPs) smartphone platform be applied as an on-site device in field. The AgNPs was investigated with other cations (Cr3+, Fe3+, Mn2+, Fe2+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+and Pb2+) at pH 3-10. results showed that this functionalized selectively binded 10, which caused color solution changing from yellow orange-red can measured by application...