A5045920341- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Electrochemical sensors and biosensors
- Phytochemical compounds biological activities
- Biosensors and Analytical Detection
- Molecular Sensors and Ion Detection
- Electrochemical Analysis and Applications
- Curcumin's Biomedical Applications
- Virus-based gene therapy research
- Synthesis and Characterization of Heterocyclic Compounds
- RNA and protein synthesis mechanisms
- Multicomponent Synthesis of Heterocycles
- Nanoparticle-Based Drug Delivery
- Aquaculture disease management and microbiota
- Berberine and alkaloids research
- Traditional and Medicinal Uses of Annonaceae
- Natural product bioactivities and synthesis
- Ziziphus Jujuba Studies and Applications
- Phytochemical Studies and Bioactivities
- Quinazolinone synthesis and applications
- Analytical Chemistry and Sensors
- Synthesis and bioactivity of alkaloids
- Glycosylation and Glycoproteins Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Invertebrate Immune Response Mechanisms
Srinakharinwirot University
2015-2024
Bangkok University
2018
Siam University
2014
Ramkhamhaeng University
2006-2013
Phytochemical investigation of the roots Cissampelos pareira Linn. led to isolation one new pyrrole alkaloid, cissampeline (1), together with ten known alkaloids, (−)-curine (2), (−)-cyclanoline (3), (+)-tetrandrine (4), (+)-obaberine (5), (+)-obamegine (6), (−)-oblongine (7), (+)-homoaromoline (8), (−)-nor-N׳-chondrocurine (9), trans-N-feruloyltyramine (10) and (+)-coclaurine (11). Their structures were elucidated by extensive NMR MS spectroscopic analyses. Interestingly, compound 1...
Abstract This study describes the development of a simple, reliable, and low‐cost method to rapidly detect Mn 2+ based on co‐functionalized silver nanoparticles (AgNPs) smartphone platform be applied as an on‐site device in field. The AgNPs was investigated with other cations (Al 3+ , Ba Ca Cd Co Cr Cu Fe K + Li Mg Na Ni Pb Zn ) at pH 3–10. results showed that this functionalized selectively binded 10, which caused color solution changing from yellow orange‐red can measured by application...
Yellow head virus (YHV) is a viral pathogen of shrimp that has caused high economic loss in the Thai farming industry, and RNA interference mechanism potential as control strategy, previous studies have shown injection specific double-stranded (dsRNA) can inhibit replication shrimp. However, to date, complete inhibition not been achieved. This study sought determine whether cationic liposomes mixed with an antiviral dsRNA (YHV-Pro-dsRNA) were able enhance protection against YHV. The results...
A new ent-abietane lactone, 3-oxojolkinolide (1), together with 16 known compounds, helioscopinolide E (2), (3), 3-methyl-9H-carbazole (4), carbalexin (5), B (6), glycaborinine (7), arborinine (8), 1H-indole-3-carbaldehyde (9), glycoamide (10), (11), 2-(N-methyl-2-phenylacetamido)benzoic acid (12), 2-(methylamine)-methylbenzoate (13), fraxidin (14), scopoletin (15), (-)-syringaresinol (16) and ferulic (17) were isolated from Glycosmis pentaphylla. The structures of these compounds elucidated...
Six new 14-membered ring cyclopeptide alkaloids, cambodines A-F (1-6), and two known compounds, frangufoline (7) lotusanine B (8), were isolated from the root bark extract of Ziziphus cambodiana Pierre. Their structures configurations established based on 1D 2D NMR, HRMS, ECD, X-ray crystallographic data. Compounds 1 3 are rare 5(14)-type alkaloids that possess an imidazolidin-4-one in terminal unit. The cyclopeptides tested for their vitro antiplasmodial, antitubercular, cytotoxic effects...
Lipid-mediated delivery of DNA into cells holds great promise both for gene therapy and basic research applications. The primary approach to improving transfection efficiency is the design synthesis novel cationic lipids. Alternatively, using synergistic effect different mixtures can provide another increasing efficiency. This paper describes lipids with polarheads, central core structures hydrophobic tails. enhancement cellular HEK293 was observed by combining two having aminoglycerol...
One new furanocoumarin, 3'-prenyloxypsoralen (1), and two known furanocoumarins, imperatorin (2) xanthotoxin (3) were isolated from the raw fruits of Aegle marmelos. The structures coumarins confirmed by spectroscopic evidence. Compound 1 exhibited moderate cytotoxic activity against HEK293, HeLa, MCF7, HT29 cell lines with IC50 values 31.2, 44.8, 36.3, > 50.0 µg/mL, respectively.
Cationic liposomal formulations of the telomeric G-quadruplex stabilizing ligand, 13-(2-naphthylmethoxy)berberine bromide (1), have been developed with purpose delivering 1 into nucleus cancer cells for potential telomere targeting. Berberine derivative was encapsulated in various cationic lipids 2-4 by thin film evaporation method; these are after amine protonation. The most appropriate berberine formulation that and cholesterol derived lipid 4 a weight ratio : 20 76.5% encapsulation...
T-shaped spermine-based cationic lipids with nonidentical chains showed excellent transfection efficiency compared to the commercially available agent, Lipofectamine 3000.
Pinostrobin (PS) extracted from fingerroot was successfully applied as a dual signalling optical sensor that selectively detected Fe3+ and Al3+ via colorimetric fluorometric methods, respectively. The selectivity of detection pH-dependent optimal at pH 7. Chelation between PS resulted in the formation brown complex with maximum absorbance 335.0 nm, while colorless caused an enhancement fluorescent intensity wavelength 500.0 nm. linearity range for were 1-150 ppm 0.05-100 Al3+. limits 0.27...
Abstract A variety of the title pyrimidinone derivatives (IV) (12 examples) are synthesized utilizing a CuSO 4 ‐catalyzed multicomponent Biginelli reaction.
In this study, N'-(3-aminopropyl)-N-(3'-(carbamoyl cholesteryl) propyl)-glycine amide (A) and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE, D) (AD) liposomes were synthesised at molar ratios of 50:25 (AD5025), 50:50 (AD5050) 50:75 (AD5075) complexed with plasmid, pTRAIL-EGFP. AD liposome/pTRAIL-EGFP evaluated for their complex ability, particle size, polydispersity index, zeta potential, expression pTRAIL-EGFP, cytotoxicity, cell growth inhibition apoptosis induction in KB cells....
This study describes the development of a simple, reliable, and low-cost method to rapidly detect Mn2+ based on co-functionalized silver nanoparticles (AgNPs) smartphone platform be applied as an on-site device in field. The AgNPs was investigated with other cations (Cr3+, Fe3+, Mn2+, Fe2+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+and Pb2+) at pH 3-10. results showed that this functionalized selectively binded 10, which caused color solution changing from yellow orange-red can measured by application...