A5002671916- Natural product bioactivities and synthesis
- Andrographolide Research and Applications
- Traditional and Medicinal Uses of Annonaceae
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Curcumin's Biomedical Applications
- Phytochemistry and Biological Activities
- Bioactive Compounds and Antitumor Agents
- Phytochemical compounds biological activities
- Synthesis of Organic Compounds
- Natural Compound Pharmacology Studies
- Biological Activity of Diterpenoids and Biflavonoids
- Molecular Sensors and Ion Detection
- Drug Transport and Resistance Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Advanced biosensing and bioanalysis techniques
- Cancer therapeutics and mechanisms
- Morinda citrifolia extract uses
- MicroRNA in disease regulation
- PARP inhibition in cancer therapy
- Mesenchymal stem cell research
- Carbohydrate Chemistry and Synthesis
- Luminescence and Fluorescent Materials
- Bioactive natural compounds
- Phytochemistry and biological activities of Ficus species
Mahidol University
2015-2024
Bangkok University
2016
Burapha University
2012
Ramkhamhaeng University
2009
Siriraj Hospital
2009
Curcuma comosa Roxb. has traditionally been used as a dietary supplement for health promotion in peri- and postmenopausal women Thailand. We investigated the estrogenic activity of 7 naturally occurring diarylheptanoids from extracts C. both vitro vivo. A yeast recombinant system containing human estrogen receptor α, coactivator TIF2 β-galactosidase reporter gene was to determine metabolically activated with rat liver S9-fraction prior assay. The most potent compound...
A rhodamine-based fluorescent chemodosimeter rhodamine hydrazide-triazole (RHT) tethered with a triazole moiety was developed for Cu2+ detection. In aqueous medium, the RHT probe exhibited high selectivity and sensitivity toward among other metal ions. The addition of triggered fluorescence emission by 384-fold (Φ = 0.33) based on ring-opening process subsequent hydrolysis reaction. Moreover, also showed selective colorimetric response from colorless solution to pink, readily observed naked...
Diarylheptanoids from Curcuma comosa, of the Zingiberaceae family, exhibit diverse estrogenic activities. In this study we investigated activity a major hydroxyl diarylheptanoid, 7-(3,4 -dihydroxyphenyl)-5-hydroxy-1-phenyl-(1E)-1-heptene (compound 092) isolated C. comosa. The compound elicited different transcriptional activities estrogen agonist at low concentrations (0.1–1 μM) and antagonist high (10–50 using luciferase reporter gene assay in HEK-293T cells. human breast cancer (MCF-7)...
The Wnt/β-catenin signaling pathway plays a key role in the progression of human colorectal cancers (CRCs) and is one leading targets chemotherapy agents developed for CRC. present study aimed to investigate anti-cancer effects molecular mechanisms 19-O-triphenylmethyl andrographolide (RS-PP-050), an analogue determine its activity pathway. RS-PP-050 was found potently inhibit proliferation survival HT-29 CRC cells. It induces cell cycle arrest promotes apoptotic death which associated with...
A propargyl–rhodol conjugate is a highly selective reaction-based fluorescent chemosensor for Au<sup>3+</sup>.
A decline of estrogen in menopause women is accompanied with increases many pro-inflammatory cytokines and osteoporosis. Andrographolide (AP), from Andrographis paniculata, which has an anti-inflammatory activity, may have potential to alleviate osteoporosis during deficiency. Here we report the promoting effects AP on differentiation mouse pre-osteoblastic (MC3T3-E1) cells by increasing expression activity alkaline phosphatase (ALP), osteoblastic gene-specific marker. also accelerated bone...
Eight new cycloartane triterpenoids (1–8), named carinatins A–H, and the known compounds secaubryolide (9) dikamaliartane D (10) were isolated from leaves twigs of Gardenia carinata. Their structures determined on basis spectroscopic methods. Cytotoxic, antitopoisomerase IIα, anti-HIV-1 activities 1–7, 9, 10 investigated.
Abstract Introduction The in vitro expansion and differentiation of mesenchymal stem cells derived from bone marrow (BM-hMSCs) are considered as potential therapeutic tools for clinical applications tissue engineering regenerative medicine. However, invasive sampling reduction number proliferative capacity with age the major limitations BM-hMSCs. Recently, human placenta-derived MSCs (PL-hMSCs) obtained by a non-invasive procedure have attracted much interest. Attempts to increase PL-hMSCs...