A5103148868- Spondyloarthritis Studies and Treatments
- Infectious Diseases and Tuberculosis
- Inflammasome and immune disorders
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Macrophage Migration Inhibitory Factor
- Systemic Lupus Erythematosus Research
- Mycobacterium research and diagnosis
- Cell Adhesion Molecules Research
- Streptococcal Infections and Treatments
- Tuberculosis Research and Epidemiology
- Medical Imaging and Analysis
- Ferroptosis and cancer prognosis
- Cellular Mechanics and Interactions
- Hematological disorders and diagnostics
- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Spinal Cord Injury Research
- Pelvic and Acetabular Injuries
- Cancer Cells and Metastasis
- Management of metastatic bone disease
- Synthesis and biological activity
- Cancer Mechanisms and Therapy
First Affiliated Hospital of GuangXi Medical University
2023-2025
Guangxi Medical University
2023-2025
Guangxi University of Chinese Medicine
2015-2022
Guangxi University
2015-2020
Abstract Spinal cord injury (SCI) is a prevalent and serious complication among patients with spinal tuberculosis (STB) that can lead to motor sensory impairment potentially paraplegia. This research aims identify factors associated SCI in STB develop clinically significant predictive model. Clinical data from at single hospital were collected divided into training validation sets. Univariate analysis was employed screen clinical indicators the set. Multiple machine learning (ML) algorithms...
The conventional open decompression surgery for degenerative lumbar lateral recess stenosis (DLLRS) yields definitive therapeutic outcomes; however, it confronts numerous challenges, including extensive surgical trauma and iatrogenic spinal instability. purpose of this study is to investigate the outcomes full-endoscopic DLLRS by an interlaminar approach. A consecutive cohort 275 patients, 148 males 127 females, with average age 64.62 (55-82) years, between July 2021 December 2022, was...
We determined the relationship between ferroptosis and immune cells in ankylosing spondylitis role of Chinese herbal medicine Cassia twigs treating spondylitis. analyzed clinical data on spondylitis, transcriptome data, single-cell sequencing genes related to twigs. Clinical variables AS were selected through logistic regression analysis combined with machine learning. GSEA enrichment performed ferroptosis, drug-related genes, identify key drug targets AS, as well as, cells. Then, cell...
Objective: The objective of this study was to utilize machine learning techniques analyze perioperative factors and identify blood glucose levels that can predict the occurrence surgical site infection following posterior lumbar spinal surgery. Methods: A total 4019 patients receiving internal fixation surgery from an institute were enrolled between June 2012 February 2021. First, filtered data randomized into test verification groups. Second, in group, specific variables screened using...
Previous studies have reported an association between inflammatory cytokines and arthritis, including Ankylosing spondylitis (AS), rheumatoid arthritis (RA), psoriatic (PsA). This study aims to explore the causal relationship AS, RA, PsA using Mendelian randomization (MR).
This study aims to investigate the anatomical structure of C6 pedicle and lateral mass in children aged 0-14 years using CT imaging, providing detailed insights into their growth development.
The identification of spinal tuberculosis subphenotypes is an integral component precision medicine. However, we lack proper study models to identify in patients with tuberculosis. Here identified possible and compared their clinical results.A total 422 who received surgical treatment were enrolled. Clustering analysis was performed using the K-means clustering algorithm routinely available data collected from within 24 h after admission. Finally, differences characteristics, efficacy,...
Background Cinnamomi ramulus (C. ramulus) is frequently employed in the treatment of ankylosing spondylitis (AS). However, primary constituents, drug targets, and mechanisms action remain unidentified.
Abstract Objective Immune checkpoints have emerged as promising therapeutic targets for autoimmune diseases. However, the specific roles of immune in pathophysiology ankylosing spondylitis (AS) remain unclear. Methods Hip ligament samples were obtained from two patient groups: those with AS and femoral head deformity, necrosis but without AS, undergoing hip arthroplasty. Label-Free Quantification (LFQ) Protein Park Analysis was used to identify protein composition ligaments. Peripheral blood...
Shenling Baizhu additive powder (SLBZ-AP), a formulation of variety natural medicinal plants, has clinical efficacy in treating cancers previous studies. We explored the effect SLBZ-AP bone metastasis lung cancer (BMLC) mice, and possible mechanism involved was further investigated present study. Mice model BMLC made treated with SLBZ-AP. Pain behavioral tests were performed to explore on BMLC-induced pain mice. TUNEL staining used investigate apoptosis. The mRNA expression markers...
The aim of the present study was to analyze expression focal adhesion kinase (FAK) in osteosarcoma (OS) cell lines with different migration abilities order determine role FAK migration. A number 143B subclone (A1, A2, A3, A4 and A5) were obtained by a limiting dilution method, detected using western blot analysis. OS cells investigated small interfering RNA (siRNA), ratio lamellipodia compared immunofluorescence staining. A2 A3 demonstrated stronger ability exhibited higher A1 line (P<0.05)....
Abstract Aims Our team tested spinal cord fusion (SCF) using the neuroprotective agent polyethylene glycol (PEG) in different animal (mice, rats, and beagles) models with complete transection. To further explore application of SCF for treatment paraplegic patients, we developed a new clinical procedure called vascular pedicle hemisected transplantation (vSCT) this eight participants. Methods Eight participants (American Spinal Injury Association, ASIA: A) were enrolled treated vSCT (PEG was...
Spinal cord injury (SCI) can cause paralysis and serious chronic morbidity, there is no effective treatment. Based on our previous experimental results of spinal fusion (SCF) in mice, rats, beagles, monkeys, we developed a surgical protocol SCF for paraplegic human patients. We designed novel procedure SCF, called sural nerve transplantation (SNT), patients with lower thoracic SCI distal dysfunction.
This study focused on the development and validation of a diagnostic model to differentiate between spinal tuberculosis (STB) pyogenic spondylitis (PS). We analyzed total 387 confirmed cases, out which 241 were diagnosed with STB 146 PS. These cases randomly divided into training group (n = 271) 116). Within group, four machine learning (ML) algorithms (least absolute shrinkage selection operator [LASSO], logistic regression analysis, random forest, support vector recursive feature...
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Background Machine learning (ML), a subset of artificial intelligence (AI), uses algorithms to analyze data and predict outcomes without extensive human intervention. In healthcare, ML is gaining attention for enhancing patient outcomes. This study focuses on predicting additional hospital days (AHD) patients with cervical spondylosis (CS), condition affecting the spine. The research aims develop an ML-based nomogram model analyzing clinical demographic factors estimate length stay (LOS)....
Objective The C4 is the transition point between upper and lower cervical vertebrae plays a pivotal role in middle of spine. Currently, there are limited reports on large‐scale sample studies regarding anatomy children, scarcity experience exists pediatric spine surgery. current study addresses dearth anatomical measurements vertebral arch lateral mass substantial children. This aims to measure imaging children under 14 years age across various groups, investigate growth development these...
Abstract The proteome serves as the primary basis for identifying targets treatment. This study conducted proteomic range two-sample Mendelian randomization (MR) analysis to pinpoint potential protein markers and treatment ankylosing spondylitis (AS). A total of 4907 data points on circulating expression were collected from a large-scale quantitative trait locus investigation involving 35,559 individuals. Using Finnish AS outcome, dataset comprised 166,144 individuals European ancestry (1462...
Despite continued efforts to manage and control Tuberculosis (TB) in China, it remains a major health concern. Bone tuberculosis (Bone-TB), common form of extrapulmonary tuberculosis, still adds considerably the global TB case load. Diagnosing Bone-TB is often difficult as its symptoms can be similar other bone or joint diseases, which leads delayed detection treatment. Currently, comprehensive reports on epidemiological aspects China are scarce. This retrospective study analyzed demographic...
ABSTRACT To uncover the complex immune mechanisms driving inflammation in ankylosing spondylitis and lay groundwork for identifying new therapeutic targets innovative approaches, we conducted 10× single‐cell sequencing on bone marrow cell samples collected from vertebrae of three AS patients non‐AS patients. Using data, analysed expression differentially expressed genes (DEGs) by comparing with Key among related DEGs were identified through protein–protein interaction networks hub gene...