A5062681018- Diet and metabolism studies
- Gut microbiota and health
- Protein Tyrosine Phosphatases
- Tryptophan and brain disorders
- Nutritional Studies and Diet
- Synthesis of Organic Compounds
- PI3K/AKT/mTOR signaling in cancer
University of East Anglia
2018-2019
Apolipoprotein E (APOE) genotype is the strongest prevalent genetic risk factor for Alzheimer's disease (AD). Numerous studies have provided insights into pathologic mechanisms. However, a comprehensive understanding of impact APOE on microflora speciation and metabolism completely lacking. In this study, we investigated association between gut microbiome composition in human APOE–targeted replacement (TR) transgenic mice. Fecal microbiota amplicon sequencing from matched individuals with...
Abstract Apolipoprotein E ( APOE ) genotype is the strongest prevalent genetic risk factor for Alzheimer’s disease. Numerous studies have provided insights into pathological mechanisms. However, a comprehensive understanding of impact on microflora speciation and metabolism completely lacking. The aim this study was to investigate association between gut microbiome composition in human APOE- targeted replacement (TR, APOE3 APOE4 transgenic mice. Faecal microbiota amplicon sequencing from...