A5056629925- Gut microbiota and health
- Diet and metabolism studies
- Colorectal Cancer Screening and Detection
- Nutritional Studies and Diet
- Biochemical and Structural Characterization
- Glycosylation and Glycoproteins Research
- Toxin Mechanisms and Immunotoxins
- Mycobacterium research and diagnosis
- Genetic factors in colorectal cancer
- Dietary Effects on Health
- Food composition and properties
- Metal Extraction and Bioleaching
- Collaboration in agile enterprises
- Metal-Catalyzed Oxygenation Mechanisms
- Diverticular Disease and Complications
- Acute Kidney Injury Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Food Supply Chain Traceability
- Liver Disease and Transplantation
- Vitamin C and Antioxidants Research
- Global Cancer Incidence and Screening
- Cancer Immunotherapy and Biomarkers
- Combustion and Detonation Processes
- Minerals Flotation and Separation Techniques
- Alcoholism and Thiamine Deficiency
Can Tho University
2018-2025
Vietnam Academy of Science and Technology
2022-2024
Hanoi University of Science and Technology
2022-2024
University College Cork
2018-2023
APC Microbiome Institute
2018-2023
National University of Ireland
2019
Laboratoire de Chimie Bactérienne
2017
Centre National de la Recherche Scientifique
2017
Aix-Marseille Université
2017
Laboratoire Information Génomique et Structurale
2015
Apolipoprotein E (APOE) genotype is the strongest prevalent genetic risk factor for Alzheimer's disease (AD). Numerous studies have provided insights into pathologic mechanisms. However, a comprehensive understanding of impact APOE on microflora speciation and metabolism completely lacking. In this study, we investigated association between gut microbiome composition in human APOE–targeted replacement (TR) transgenic mice. Fecal microbiota amplicon sequencing from matched individuals with...
There are complex interactions between aging, frailty, diet, and the gut microbiota; modulation of microbiota by diet could lead to healthier aging. The purpose this study was test effect diets differing in sugar, fat, fiber content upon mice humanized with from healthy or frail older people. We also performed a 6-month dietary supplementation three human cohorts representing distinct life-stages.Mice were colonized then underwent an 8-week intervention either high-fiber/low-fat typical...
Blueberry (BB) consumption is linked to improved health. The bioconversion of the polyphenolic content BB by fermentative bacteria in large intestine may be a necessary step for health benefits attributed consumption. identification specific gut microbiota taxa that respond and mediate consumed compounds into bioactive forms required improve our understanding how polyphenols impact human We tested ability polyphenol-rich fractions purified from whole BB—namely, anthocyanins/flavonol...
Vitamin K has multiple important physiological roles, including blood coagulation and beneficial effects on myelin integrity in the brain. Some intestinal microbes possess genes to produce vitamin form of menaquinone (MK). MK appears higher concentration tissues, such as brain, particularly MK4, than dietary phylloquinone (PK). Lower PK concentrations have been reported patients with Alzheimer disease while serum positively associated verbal episodic memory. Despite knowledge importance for...
Considering the importance of tRNAs in translation machinery, scant attention has been paid to tRNA array units defined as genomic regions containing at least 20 genes with a minimal gene density two per kilobase. Our analysis Acidithiobacillus ferrivorans CF27 and ferrooxidans ATCC 23270 T genomes showed that both display unit syntenic conservation which mainly contributed redundancy these organisms. investigations into occurrence distribution revealed 1) this organization is limited few...
Thioredoxin reductase (TR) regulates the intracellular redox environment by reducing thioredoxin (Trx). In anaerobes, recent findings indicate that Trx network is implicated in global regulation of metabolism but also actively participates protecting cells against O2. anaerobe Desulfovibrio vulgaris Hildenborough (DvH), there an intriguing redundancy system which includes a classical using NADPH as electron source, non-canonical NADH and isolated TR (DvTRi). The functionality DvTRi was...
Gut microbiota alterations are associated with obesity and type 2 diabetes. Yeast β-glucans potential modulators of the innate immune-metabolic response, by impacting glucose, lipid, cholesterol homeostasis. The study examines whether yeast β-glucan interacts differentially either an obese healthy or diabetic gut microbiome, to impact metabolic health through hepatic effects under high-fat dietary challenge.
One of the sectors which contributes importantly to development Vietnam economy is fishery industry. However, during recent year, it has been witnessed many difficulties on managing performance supply chain operations as a whole. In this paper, framework for risk management (SCRM) proposed. Initially, all activities are mapped by using Supply Chain Operations Reference (SCOR) model. Next, ranking analyzed in House Risk. Furthermore, interpretive structural modeling (ISM) used identify...
Aim: Dietary fibre is important for shaping gut microbiota. The aim of this pilot study was to investigate the impact dietary fibres on pathogen performance in presence Methods: In an ex vivo model, pooled faecal samples were spiked with a cocktail representative gastrointestinal pathogens and fermented yeast β-glucan 24 hours, after which 16S rRNA amplicon sequencing short-chain branched-chain fatty acid (SCFA BCFA) analyses performed. addition, oat β-glucan, arabinoxylan,...
The iron-oxidizing species Acidithiobacillus ferrivorans is one of few acidophiles able to oxidize ferrous iron and reduced inorganic sulfur compounds at low temperatures (<10°C). To complete the genome At. strain CF27, new sequences were generated, an update assembly functional annotation undertaken, followed by a comparative analysis with other whose genomes are publically available. CF27 comprises 3,409,655 bp chromosome 46,453 plasmid. possesses genes allowing its adaptation cold,...
Background and AimsMutations in DNA mismatch repair (MMR) genes are causative Lynch syndrome a significant proportion of sporadic colorectal cancers (CRCs). MMR-deficient (dMMR) CRCs display increased mutation rates, with mutations frequently accumulating at short repetitive sequences throughout the genome (microsatellite instability). The TGFBR2 gene is one most mutated dMMR CRCs. Therefore, we generated an animal model to study how loss both signaling impacts dMMR-driven intestinal...
IL-1RI-mediated inflammatory signaling alters metabolic tissue responses to dietary challenges (e.g., high-fat diet [HFD]). Recent work suggests that phenotype is transferrable between mice in a shared living environment (i.e., co-housing) due gut microbiome exchange. The authors examine whether the of IL-1RI-/- fed HFD or low-fat (LFD) could be transferred wild-type (WT) through exchange facilitated by co-housing.Male WT (C57BL/J6) and are (45% kcal) LFD (10% for 24 weeks housed i) genotype...
Elevated serum uric acid levels have been associated with numerous clinical phenotypes, including gout, kidney disease, and cardiovascular complications. There is conflicting evidence for the role of urate in disease (CVD) etiology symptomatology: while some studies point toward a causal acid, others suggest noncausal association. The All Us Research Program contains genomic electronic health record (EHR) data approximately 250,000 participants diverse genetic backgrounds.
Abstract Introduction: Early detection through routine screening is also necessary to improve the mortality rate of colorectal cancer (CRC). However, testing up date in only 63% eligible adults, and rates are lower among minority race/ethnicity groups underinsured. Fecal immunochemical test (FIT) non-invasive, home-based kit that has been an important cost-effective option resource-limited settings. Vietnamese Americans were disproportionally affected by CRC, yet this population suboptimal....
Abstract Purpose The fecal immunochemical test (FIT) is a non-invasive method for colorectal cancer (CRC) screening, particularly effective in underserved Vietnamese American communities with low screening rates. This study reports on culturally tailored multilevel intervention, incorporating FIT, aimed at increasing CRC among these populations aged 50 or above the Greater Philadelphia metropolitan area. Methods From 2017 to 2020, we conducted two-arm cluster randomized controlled trial...
Burkholderia dolosa is a clinically important opportunistic pathogen in inpatients. Here we characterised an extensively drug-resistant and hypervirulent B. isolate from patient hospitalised for stroke. Resistance to 41 antibiotics was tested with the agar disc diffusion, minimum inhibitory concentration, or broth microdilution method. The complete genome assembled using short-reads long-reads hybrid de novo assembly Allelic profiles obtained by multilocus sequence typing were analysed...
Abstract Cyclotides, cysteine‐rich peptides, are derived from various plant sources. Within the Fabaceae family, Clitoria ternatea Linn distinguishes itself as only species that has been confirmed to contain cyclotides in its tissues. Several investigations have undertaken identify and evaluate activity of plant. However, investigation mature pods C. remains unexplored. To fill this gap, study utilized three different extraction methods employed LC–MS analysis their effectiveness extracting...
Abstract Patients with colorectal cancer (CRC) harbor gut microbiomes that differ in structure and function from those of healthy individuals, suggesting this altered microbiome could contribute to tumorigenesis. Despite increasing evidence implicating the CRC, collective role different microbial consortia CRC carcinogenesis is unclear. We have previously described these as co-abundance groups co-exist at abundance levels same patient. Here, we report tumor biopsy tissue patients a...
Despite increasing evidence implicating the gut microbiome in CRC, collective role of different microbial consortia CRC carcinogenesis is unclear. We have previously described these as co-abundance groups that co-exist at abundance levels same patient. Here, we report tumor biopsy tissue from patients with a “high-risk” Pathogen-type had immune transcriptome and cell infiltrate those “low-risk” Lachnospiraceae-type microbiome. Transplantation two fecal types into mice an orthotopic...