A5031133523- Burkholderia infections and melioidosis
- Plant Pathogens and Fungal Diseases
- Antifungal resistance and susceptibility
- Yeasts and Rust Fungi Studies
Princess of Naradhiwas University
2020-2022
Mahidol Oxford Tropical Medicine Research Unit
2020
Mahidol University
2020
Abstract Tetraspanins are four-span transmembrane proteins of host cells that facilitate infections by many pathogens. Burkholderia pseudomallei is an intracellular bacterium and the causative agent melioidosis, a severe disease in tropical regions. This study investigated role tetraspanins B. infection. We used flow cytometry to determine CD9, CD63, CD81 expression on A549 J774A.1 cells. Their roles infection were vitro using monoclonal antibodies (MAbs) recombinant large extracellular loop...
Background Burkholderia pseudomallei is an environmental bacterium that causes melioidosis. A facultative intracellular pathogen, B. can induce multinucleated giant cells (MNGCs) leading to plaque formation in vitro. switch colony morphotypes under stress conditions. In addition, different isolates have been reported varying virulence vivo, but genomic evolution and the relationship with poorly understood. Methodology/Principle findings To gain insights into genetic underpinnings of...
The basidiomycetes yeast Trichosporon is widespread in the natural environment, but can cause disease, mainly immunocompromised patients. However, there have been only few studies about this infection Thailand. In study, we characterized 53 spp. isolated from urine samples patients admitted to a single hospital Bangkok, Thailand over one-year period 2019 2020. strains were identified using colony morphology, microscopy, matrix-assisted laser desorption/ionization time-of-flight mass...