A5056523738- Heme Oxygenase-1 and Carbon Monoxide
- Liver Disease Diagnosis and Treatment
- Curcumin's Biomedical Applications
- Mesenchymal stem cell research
- Reproductive Biology and Fertility
- Ferroptosis and cancer prognosis
- Diabetes and associated disorders
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Pancreatic function and diabetes
- Extracellular vesicles in disease
- Neuroscience of respiration and sleep
- Pluripotent Stem Cells Research
- Cannabis and Cannabinoid Research
- Effects and risks of endocrine disrupting chemicals
- Endoplasmic Reticulum Stress and Disease
- Cancer, Lipids, and Metabolism
- Liver physiology and pathology
- Ovarian function and disorders
- Epigenetics and DNA Methylation
- Air Quality and Health Impacts
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Pancreatitis Pathology and Treatment
- Bladder and Urothelial Cancer Treatments
Cairo University
2015-2024
Suez University
2021-2024
Galala University
2021-2024
Benha University
2016-2024
University of Ha'il
2016-2017
Loyola University Medical Center
2017
National Water Research Center
2009-2016
Beni-Suef University
2013
Abstract Background The present study was conducted to evaluate the tumor suppressive effects of bone marrow derived mesenchymal stem cells (MSCs) in an experimental hepatocellular carcinoma (HCC) model rats and investigate possible role Wnt signaling hepato-carcinogenesis. Methods Ninety were included divided equally into: Control group, which received MSCs only, vehicle HCC group induced by diethylnitroseamine (DENA) CCl 4 , after induction, before induction. Histopathological examination...
Diabetes mellitus type 1 is an autoimmune disorder caused by lymphocytic infiltration and beta cells destruction. Curcumin has been identified as a potent inducer of heme-oxygenase-1 (HO-1), redoxsensitive inducible protein that provides protection against various forms stress. A novel water soluble curcumin derivative (NCD) developed to overcome low in vivo bioavailability curcumin. The aim the present work evaluate anti diabetic effects "NCD" its on diabetes-induced ROS generation lipid...
Curcumin exhibits anti-diabetic activities, induces heme-oxygenase-1 (HO-1) and is an inhibitor of transcriptional co-activator p300. A novel water soluble curcumin derivative (NCD) has been developed to overcome low invivo bioavailability curcumin. We evaluated the effect NCD on signaling mechanisms involved in cardiomyocyte hypertrophy studied whether its action mediated via inducible HO-1.Rats were divided into controls, controls receiving NCD, diabetic, diabetic pure curcumin, HO...
Abstract The present study assessed protein and gene expression levels of tissue inhibitor metalloproteinase‐2 (TIMP‐2), matrix (MMP‐2), MMP‐9 in urine blood samples 50 patients with bladder carcinoma. TIMP‐2, MMP‐2, tumor stage grade was also assessed. Results showed that the MMP‐2 both were significantly elevated group 1 when compared groups 2 3 healthy subjects. discriminatory ability diagnosis carcinoma confirmed by receiver operating characteristic curve analysis revealed a sensitivity...
Several studies highlight curcumin's benefit as a hypoglycemic agent, however; limited number of reports present the importance curcumin in improvement pancreatic islets diabetes. The aim study is to evaluate antidiabetic effect novel derivative and its on islet regeneration type I diabetes-induced by STZ.Rats were divided into diabetic rats treated orally with (NCD) for 40 days. Fasting blood samples withdrawn periodically from all estimate plasma glucose, insulin C-peptide 10 months....
The present study was conducted to compare between the therapeutic efficacies of human amniotic membrane-derived stem cells (hAM-MSCs) vs. adipose tissue derived (AD-MSCs) in cyclophosphamide (CTX)-induced ovarian failure rats. Forty-eight adult female rats were included study; 10 used as control group. Thirty-eight injected with CTX induce and divided into four groups: (IOF) (IOF group), IOF + phosphate buffer saline (PBS hAM-MSCs group AD-MSCs Serum levels FSH estradiol (E2) assessed....
Gastric cancer (GC) is considered lethal aggressive cancer. In Egypt, GC has a low incidence but unfortunately, it mostly diagnosed at an advanced stage with poor prognosis. Assessment of novel markers that can be used in the early detection urgent need. The present study was performed to assess association Pleckstrin homology domain-containing S1 (PLEKHS1)، arylacetamide deacetylase (AADAC, and Cyclin-dependent kinase inhibitor 3 (CDKN3) genes correlate their gene expression levels tumor...
El-Karaksy HM, Anwar G, Esmat Mansour S, Sabry M, Helmy H, El-Hennawy A, Fouad H. Prevalence of hepatic abnormalities in a cohort Egyptian children with type 1 diabetes mellitus. Background and aim: Children mellitus (T1DM) are frequently investigated for abnormalities. This study was carried out to report on the prevalence diabetic adolescents highlight possible etiology appropriate management. Methods: The included 692 (333 were males) T1DM attending Diabetes Unit at Cairo University...
The vitamin D receptor (VDR) gene is a candidate for susceptibility to autoimmune disorders. To study the frequency of deficiency in Egyptian systemic lupus erythematosus (SLE) patients and investigate association BsmI FokI VDR polymorphisms with disease susceptibility, activity damage. Forty-five SLE 40 controls were enrolled. Disease Activity Index (SLEDAI) Systemic Lupus International Collaborating Clinics (SLICC) damage index assessed patients. Serum levels measured all subjects....
Hyperglycemia induces activation of the c-Jun N-terminal kinase (JNK) pathway, which suppresses insulin gene expression and reduces DNA binding pancreatic duodenal homeobox factor (PDX)-1. This study aims to investigate effects a novel curcumin derivative (NCD) on JNK signaling pathway synthesis secretion in streptozotocin (STZ)-treated rat islets vitro.Isolated were divided into five groups: untreated control group; group treated with NCD (10 μM); exposed STZ (5 mM); μM) then mM) μM). The...
Selective MSCs differentiation protocol into pancreatic beta cells was conducted in the present study using exendin-4 and TGF-beta. Differentiated undifferentiated were assessed experimental type I diabetes rats. Ninety female white albino rats included divided equally (n=15/group) 6 groups: healthy control, control received acellular tissue culture medium, diabetic rats, differentiated MSCs. Therapeutic efficacy of versus evaluated via assessment quantitative gene expressions insulin1,...
The efficacy of a novel curcumin derivative (NCD) versus tadalafil in erectile signalling was assessed. Ten control male rats and 50 diabetic were used divided into the following: (DM), (CURC), NCD, NCD combined with rat groups. Cavernous tissue gene expression heme oxygenase-1 (HO-1), Nrf2, NF-B p38, enzyme activities oxygenase (HO) nitric oxide synthase (NOS), cGMP intracavernosal pressure (ICP)/mean arterial (MAP) Results showed that 12 weeks after induction diabetes, dysfunction (ED)...
This work aimed to assess the efficacy of haeme oxygenase-1 (HO-1) cDNA-liposome complex transfer as a mediator erectile signalling in aged rats. One hundred and fifty white albino rats were equally divided into five groups: controls, receiving lipofectamine, intracorporeal HO-1 cDNA-lipsome complex, plus nitric oxide synthase (NOS) inhibitor, HO inhibitor. Six killed from each group after 12, 24 48 h, after1 2 weeks. In dissected cavernous tissues, following assessed: gene expression,...