A5036981501- RNA Research and Splicing
- Plant and Fungal Interactions Research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Genetics, Aging, and Longevity in Model Organisms
- RNA and protein synthesis mechanisms
- Molecular Biology Techniques and Applications
- Microtubule and mitosis dynamics
- MicroRNA in disease regulation
- CRISPR and Genetic Engineering
- RNA regulation and disease
- Fungal and yeast genetics research
- Circular RNAs in diseases
- Algal biology and biofuel production
- Photosynthetic Processes and Mechanisms
ORCID
2022
University of Oxford
2018-2022
University College London
2021-2022
École Polytechnique Fédérale de Lausanne
2015
In mammalian cells, small non-coding RNAs (sncRNAs) negatively regulate gene expression in a pathway known as RNA interference (RNAi). RNAi can be categorized into post-transcriptional silencing (PTGS), which involves the cleavage of target messenger (mRNA) or inhibition translation cytoplasm, and transcriptional (TGS), is mediated by establishment repressive epigenetic marks at loci. Transfer (tRNAs), are essential for translation, processed ncRNAs, termed tRNA-derived (tsRNAs). The...
Centrioles are microtubule-based organelles crucial for cell division, sensing and motility. In Caenorhabditis elegans, the onset of centriole formation requires notably proteins SAS-5 SAS-6, which have functional equivalents across eukaryotic evolution. Whereas molecular architecture SAS-6 its role in initiating well understood, mechanisms by relatives function is unclear. Here, we combine biophysical structural analysis to uncover examine implications vivo. Our work reveals that two...
Eukaryotic genomes express numerous long intergenic non-coding RNAs (lincRNAs) that do not overlap any coding genes. Some lincRNAs function in various aspects of gene regulation, but it is clear general to what extent contribute the information flow from genotype phenotype. To explore this question, we systematically analysed cellular roles Schizosaccharomyces pombe . Using seamless CRISPR/Cas9-based genome editing, deleted 141 lincRNA genes broadly phenotype these mutants, together with 238...
Eukaryotic genomes express numerous long intergenic non-coding RNAs (lincRNAs) that do not overlap any coding genes. Some lincRNAs function in various aspects of gene regulation, but it is clear general to what extent contribute the information flow from genotype phenotype. To explore this question, we systematically analyzed cellular roles Schizosaccharomyces pombe. Using seamless CRISPR/Cas9-based genome editing, deleted 141 lincRNA genes broadly phenotype these mutants, together with 238...
In mammalian cells, endogenous small RNAs regulate gene expression in a pathway known as RNA interference (RNAi) (Hannon, 2002). RNAi can be generally categorised into post-transcriptional silencing (PTGS), which involves the destabilisation of mature messenger or inhibition translation cytoplasm (Bartel, 2018) and transcriptional (TGS) mediated by establishment repressive epigenetic marks across target genes on chromatin (Weinberg Morris, 2016). Transfer (tRNAs), are essential for...