A5086229954- RNA Research and Splicing
- Plant and Fungal Interactions Research
- Plant-Microbe Interactions and Immunity
- Plant Pathogenic Bacteria Studies
- Molecular Biology Techniques and Applications
- Plant Parasitism and Resistance
- Cancer-related molecular mechanisms research
- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- Light effects on plants
- RNA modifications and cancer
- Fungal and yeast genetics research
- RNA regulation and disease
- Plant Virus Research Studies
- Plant Ecology and Taxonomy Studies
- Insect Resistance and Genetics
- RNA and protein synthesis mechanisms
- Plant Gene Expression Analysis
- Plant Pathogens and Fungal Diseases
- Plant Pathogens and Resistance
- CRISPR and Genetic Engineering
University College London
2021-2024
Max Planck Institute for Plant Breeding Research
2014-2024
MRC Unit for Lifelong Health and Ageing
2024
University of California, Davis
2014-2023
ORCID
2022
Significance Pathogens cause disease by deploying virulence effectors that interfere with various host targets, whereas plants counteract pathogen when invoking a potent immunity known as effector-triggered (ETI). Little is about the mechanism underlying this molecular battle between plant and virulence. We find phytohormones abscisic acid jasmonate (JA), signaling pathways of which are often exploited pathogens, transcriptionally activate common family protein phosphatases suppress...
Plants recognize surrounding microbes by sensing microbe-associated molecular patterns (MAMPs) to activate pattern-triggered immunity (PTI). Despite their significance for microbial control, the evolution of PTI responses remains largely uncharacterized. Here, employing comparative transcriptomics six Arabidopsis thaliana accessions and three additional Brassicaceae species investigate responses, we identified a set genes that commonly respond MAMP flg22 exhibit species-specific expression...
Genomes produce widespread long non-coding RNAs (lncRNAs) of largely unknown functions. We characterize aal1 (ageing-associated lncRNA), which is induced in quiescent fission yeast cells. Deletion shortens the chronological lifespan non-dividing cells, while ectopic overexpression prolongs their lifespan, indicating that acts trans. Overexpression represses ribosomal-protein gene expression and inhibits cell growth, genetically interacts with coding genes functioning protein translation. The...
Eukaryotic genomes express numerous long intergenic non-coding RNAs (lincRNAs) that do not overlap any coding genes. Some lincRNAs function in various aspects of gene regulation, but it is clear general to what extent contribute the information flow from genotype phenotype. To explore this question, we systematically analysed cellular roles Schizosaccharomyces pombe . Using seamless CRISPR/Cas9-based genome editing, deleted 141 lincRNA genes broadly phenotype these mutants, together with 238...
The circadian oscillator allows organisms to synchronize their cellular and physiological activities with diurnal environmental changes. In plants, the clock is primarily composed of multiple transcriptional-translational feedback loops. Regulators post-transcriptional events, such as precursor messenger RNAs (pre-mRNA) splicing factors, are also involved in controlling pace clock. However, most cases underlying mechanisms remain unclear. We have previously identified XAP5 CIRCADIAN...
Genomes produce widespread long non-coding RNAs (lncRNAs) of largely unknown functions. We characterize aal1 (aging-associated lncRNA) which is induced in quiescent cells fission yeast. Deletion shortens the chronological lifespan non-dividing cells, while ectopic overexpression prolongs their lifespan, indicating that this lncRNA acts trans. The leads to repression ribosomal protein genes and inhibition cell growth, genetically interacts with coding functioning translation. RNA localizes...
tRNAs are evolutionarily ancient molecular decoders essential for protein translation. In eukaryotes, and other short, noncoding RNAs transcribed by RNA polymerase (Pol) III, an enzyme that promotes ageing in yeast, worms, flies. Here, we show a partial reduction Pol III activity specifically disrupts tRNA levels. This effect is conserved across flies, mice, where computational models indicate it impacts mRNA decoding. all 3 species, reduced increases proteostatic resilience. activates the...
Abstract Plants recognize surrounding microbes by sensing microbe-associated molecular patterns (MAMPs) to activate pattern-triggered immunity (PTI). Despite their significance for microbial control, the evolution of PTI responses remains largely uncharacterized. Employing comparative transcriptomics six Arabidopsis thaliana accessions and three additional Brassicaceae species MAMP flg22, we identified a set genes with expression changes under purifying selection in exhibiting...
Eukaryotic genomes express numerous long intergenic non-coding RNAs (lincRNAs) that do not overlap any coding genes. Some lincRNAs function in various aspects of gene regulation, but it is clear general to what extent contribute the information flow from genotype phenotype. To explore this question, we systematically analyzed cellular roles Schizosaccharomyces pombe. Using seamless CRISPR/Cas9-based genome editing, deleted 141 lincRNA genes broadly phenotype these mutants, together with 238...
Abstract The circadian oscillator allows organisms to synchronize their cellular and physiological activities with diurnal environmental changes. In plants, the clock is primarily composed of multiple transcriptional-translational feedback loops. Regulators post-transcriptional events, such as pre-mRNA splicing factors, are also involved in controlling pace clock. However, most cases underlying mechanisms remain unclear. We have previously identified XAP5 CIRCADIAN TIMEKEEPER ( XCT ) an...