A5085559811- Hippo pathway signaling and YAP/TAZ
- Proteoglycans and glycosaminoglycans research
- Genetics, Aging, and Longevity in Model Organisms
- Cellular Mechanics and Interactions
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Cancer-related Molecular Pathways
- Plant Surface Properties and Treatments
- RNA Research and Splicing
- Skin and Cellular Biology Research
- DNA Repair Mechanisms
- Lipid Membrane Structure and Behavior
- Science, Research, and Medicine
- RNA modifications and cancer
- Animal Genetics and Reproduction
- Connective tissue disorders research
- CRISPR and Genetic Engineering
- Plant responses to water stress
- RNA regulation and disease
- Biomedical Ethics and Regulation
- Bacterial Genetics and Biotechnology
- Virus-based gene therapy research
- Endoplasmic Reticulum Stress and Disease
- Viral Infectious Diseases and Gene Expression in Insects
- Epigenetics and DNA Methylation
MRC Unit for Lifelong Health and Ageing
2021-2024
University College London
2016-2024
University of Cambridge
2018-2020
London Cancer
2018
Bridge University
2018
King's College London
2013
The Hippo tumor suppressor pathway is essential for development and tissue growth control, encompassing a core cassette consisting of the (MST1/2), Warts (LATS1/2), Tricornered (NDR1/2) kinases together with MOB1 as an important signaling adaptor. However, it remains unclear which regulatory interactions between different coordinate development, growth, suppression. Here, we report crystal structure MOB1/NDR2 complex define key residues mediating MOB1's differential binding to kinases,...
Abstract Hyaluronan (HA) is a key component of the extracellular matrix. Given fundamental role HA in cancer resistance naked mole-rat (NMR), we undertook to explore structural and soft matter properties this species-specific variant, necessary step for its development as biomaterial. We examined extracted from NMR brain, lung, skin, well that isolated medium immortalised cells. In common with mouse HA, forms range assemblies corresponding wide distribution molecular weights. However, unique...
Naked mole-rats are extraordinarily long-lived rodents that offer unique opportunities to study the molecular origins of age-related neurodegenerative diseases. Remarkably, they do not accumulate amyloid plaques, even though their brains contain high concentrations beta (Aβ) peptide from a young age. Therefore, represent particularly favourable organism mechanisms resistance against Aβ neurotoxicity. Here we examine composition, phase behaviour, and interactions naked mole-rat brain lipids....
The long-living naked mole-rat (NMR) shows negligible senescence and resistance to age-associated diseases. Recent evidence, based on protein-level assays, suggests that enhanced protein homeostasis machinery contributes NMR stress-resistance longevity. Here, we develop NMR-specific, transcriptional assays for measuring the unfolded response (UPR), a component of ER proteostasis. By varying doses times pharmacological stressors applied kidney fibroblasts, probe UPR in detail, demonstrating...
Abstract The Naked Mole-Rat, Hetercephalus glaber , is a mouse-sized subterranean rodent native to East Africa. Research on NMRs intensifying in an effort gain leverage from their unusual physiology, long-life span and cancer resistance. Few studies have attempted explain the reasons behind resistance, but most prominently Tian et al. reported that NMR cells produce high-molecular weight hyaluronan as potential cause for NMR’s shown are resistant transformation by SV40 Large T Antigen (...
tRNAs are evolutionarily ancient molecular decoders essential for protein translation. In eukaryotes, and other short, noncoding RNAs transcribed by RNA polymerase (Pol) III, an enzyme that promotes ageing in yeast, worms, flies. Here, we show a partial reduction Pol III activity specifically disrupts tRNA levels. This effect is conserved across flies, mice, where computational models indicate it impacts mRNA decoding. all 3 species, reduced increases proteostatic resilience. activates the...
Abstract Hyaluronan (HA) is a key component of the extracellular matrix. Given fundamental role HA in cancer resistance naked mole-rat (NMR), we undertook to explore structural and soft matter properties this species-specific variant, necessary step for its development as biomaterial. We examined extracted from NMR brain, lung, skin, well that isolated medium immortalised cells. In common with mouse HA, forms range assemblies corresponding wide distribution molecular weights. However, unique...
Abstract Naked mole-rats are extraordinarily long-lived rodents that do not develop age-related neurodegenerative diseases. Remarkably, they accumulate amyloid plaques, even though their brains contain high concentrations of beta peptide, from a young age Therefore, these animals offer an opportunity to investigate mechanisms resistance against the neurotoxicity aggregation. Working in this direction, here we examine composition, phase behaviour, and interactions naked mole-rat brain lipids....