A5008788871- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- RNA modifications and cancer
- Bacterial biofilms and quorum sensing
- RNA Research and Splicing
- Gene expression and cancer classification
- Molecular Biology Techniques and Applications
- RNA and protein synthesis mechanisms
- Alcoholism and Thiamine Deficiency
- Eicosanoids and Hypertension Pharmacology
- Cervical Cancer and HPV Research
- Prion Diseases and Protein Misfolding
- Substance Abuse Treatment and Outcomes
- Amyotrophic Lateral Sclerosis Research
- RNA regulation and disease
MRC Unit for Lifelong Health and Ageing
2024
University of Oxford
2024
University College London
2022-2024
Tehran University of Medical Sciences
2013-2017
Reduced provision of protein translation machinery promotes healthy aging in a number animal models. In humans, however, inborn impairments are known cause several developmental disorders, collectively termed ribosomopathies. Here, we use casual inference approaches genetic epidemiology to investigate whether adult, tissue-specific biogenesis drives human aging. We assess naturally occurring variation the expression genes encoding subunits specific two RNA polymerases (Pols) that transcribe...
BackgroundMethicillin is the drug of choice to treat infections caused by resistant strains Staphylococcus aureus. However, methicillin-resistant S. aureus (MRSA) now becoming endemic in many hospitals worldwide and cause nosocomial outbreaks.MethodsTo assess clonality dissemination MRSA Tehran, a total 60 were isolated from hospitalized patients (n = 44) hospital equipment environment 16) three metropolitan Tehran between July 2009 March 2010. These subjected antimicrobial susceptibility...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the gradual death of motor neurons in brain and spinal cord, leading to fatal paralysis. Socioeconomic status (SES) measure an individual's shared economic social status, which has been shown have association with health outcomes. Understanding impact SES on conditions crucial, as it can influence be influenced health-related variables. The role socioeconomic influencing risk progression ALS not established,...
tRNAs are evolutionarily ancient molecular decoders essential for protein translation. In eukaryotes, and other short, noncoding RNAs transcribed by RNA polymerase (Pol) III, an enzyme that promotes ageing in yeast, worms, flies. Here, we show a partial reduction Pol III activity specifically disrupts tRNA levels. This effect is conserved across flies, mice, where computational models indicate it impacts mRNA decoding. all 3 species, reduced increases proteostatic resilience. activates the...
Abstract Background The long-term impact of opioid use disorder (OUD) on brain health has been little explored although potentially high public importance. Objectives To investigate the potential causal OUD later life outcomes, including dementia, stroke and structure. Methods Observational Mendelian randomization (MR) analyses were conducted. Participants included in observational enrolled US Million Veteran Program (MVP). Cox proportional hazards used to examine association between...
Background This study was performed to examine the clonal diversity of meticillin-resistant Staphylococcus aureus isolated from intensive care units (ICUs) 3 hospitals located in Tehran, Iran. Methods A total 67 S. were obtained ICU and subjected antimicrobial susceptibility tests pulsed-field gel electrophoresis typing. Results Twenty (30%) isolates resistant oxacillin with minimum inhibitory concentrations greater than or equal 256 μg/mL for 18 them. Pulsed-field analysis showed 4 common...
Background: In cervical cancer, more than any other type of the effects prevention, early diagnosis and prompt treatment is apparent on reduction mortality. Objectives: This study aims to achieve protein biomarkers which can be useful in cancer. Methods: this Descriptive study, out 3 patients who had a positive HPV PCR test, with symptoms tumor, samples healthy cancerous tissues were obtained perform proteomics. By standard separation techniques, total tissue proteins purified separated by...