A5009101660- Diabetes Management and Research
- Diabetes Treatment and Management
- Chronic Lymphocytic Leukemia Research
- Rheumatoid Arthritis Research and Therapies
- Pancreatic function and diabetes
- Coral and Marine Ecosystems Studies
- Plant Pathogens and Fungal Diseases
- Coastal and Marine Management
- Plant-Microbe Interactions and Immunity
- Microplastics and Plastic Pollution
- Drug Transport and Resistance Mechanisms
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Lymphoma Diagnosis and Treatment
- Pharmacogenetics and Drug Metabolism
- Land Use and Ecosystem Services
- Marine and fisheries research
- Polymer-Based Agricultural Enhancements
- Marine and coastal plant biology
- Ion Transport and Channel Regulation
- Climate Change, Adaptation, Migration
- Asian American and Pacific Histories
- Metabolism, Diabetes, and Cancer
- Amino Acid Enzymes and Metabolism
- Conservation, Biodiversity, and Resource Management
Institute for Global Environmental Strategies
2024
Astellas Pharma (Japan)
2016-2023
Institute for International Policy Studies
2022-2023
Ibero American University
2020
Tokyo Institute of Technology
2009-2016
The University of Tokyo
2013
Cimetidine, an H<sub>2</sub> receptor antagonist, has been used to investigate the tubular secretion of organic cations in human kidney. We report a systematic comprehensive analysis inhibition potency cimetidine for influx and efflux transporters [human cation transporter 1 (hOCT1) hOCT2 multidrug toxin extrusion (hMATE1) hMATE2-K, respectively]. Inhibition constants (<i>K</i><sub>i</sub>) were determined by using five substrates [tetraethylammonium (TEA), metformin,...
The recent influx of microplastics into the Arctic Ocean may increase environmental stress on western marine ecosystem, which is experiencing significant sea-ice loss due to global warming. Quantitative data in are very limited, and microplastic budget water column completely unknown. To fill gaps our knowledge microplastics, we observed surface concentrations (number particles per unit volume seawater) meso- using a neuston net, wind speeds wave heights Chukchi Sea, Bering Strait, Sea. From...
We assessed the efficacy and safety of fidaxomicin, a narrow-spectrum macrocyclic antibiotic, for treating inpatients with Clostridioides (Clostridium) difficile infection (CDI) in Japan. The objective was to demonstrate non-inferior fidaxomicin versus vancomycin.This Phase III, vancomycin-controlled, double-blind, parallel-group study enrolled adults CDI. Patients were randomly assigned receive (200 mg twice daily, orally) or vancomycin (125 four-times 10 days. primary endpoint global cure...
Abstract Aim To assess the efficacy and safety of once‐daily ipragliflozin 50 mg versus placebo in Japanese people with type 1 diabetes mellitus (T1DM) inadequately controlled insulin. Materials methods We conducted a multicentre, double‐blind, parallel‐group, placebo‐controlled phase 3 study. Participants (N = 175) were randomized (2:1) to receive (n 115) or 60), combined insulin, for 24 weeks. The primary endpoint was change glycated haemoglobin (HbA1c); key secondary endpoints included...
Peficitinib is an oral pan-Janus kinase inhibitor for the treatment of rheumatoid arthritis. Co-administration peficitinib with metformin, a type 2 diabetes therapy, can occur in clinical practice. Hepatic and renal uptake metformin mediated by organic cation transporter 1 (OCT1) OCT2, respectively, its excretion multidrug toxin extrusion (MATE1) MATE2-K. This study investigated effect on pharmacokinetics vitro healthy volunteers.Inhibitory effects metabolite H2 into human OCT1/2-...
To evaluate the pharmacodynamics, pharmacokinetics, and safety of novel oral sodium-glucose co-transporter-2 inhibitor, ipragliflozin, in Japanese patients with type 1 diabetes mellitus.We conducted a multicentre, double-blind, placebo-controlled, parallel-group study. Patients were randomized to receive 25, 50, or 100 mg/day ipragliflozin placebo for 2 weeks. Key pharmacokinetic endpoints included area under concentration-time curve 24 hours postdose (AUC24h ), maximum plasma concentration...
The illuminated parts of many hermatypic corals have higher levels photosynthetic pigments and symbiotic dinoflagellates belonging to the genus Symbiodinium than shaded that often appear pale. In field, we observed perforate coral Montipora capitata restored this original pattern after being overturned by disturbance. Here, two hypotheses were tested account for phenomenon, using experimentally M. plates in laboratory. Our results indicated restoration was not due changes chlorophyll a...
The aim of the present study was to assess long-term (52-week) efficacy and safety ipragliflozin in insulin-treated Japanese patients with type 1 diabetes mellitus inadequate glycemic control.
Abstract Peficitinib (ASP015K) is a novel Janus kinase inhibitor developed for the treatment of rheumatoid arthritis (RA). The impact hepatic impairment on peficitinib pharmacokinetic (PK) and safety profile was investigated in non‐RA subjects (n = 24) an open‐label, parallel‐group, multicenter comparative study Japan. Subjects received single, clinically relevant, oral dose 150 mg tablet under fasting conditions. Plasma PK parameters were measured its metabolites H1 (sulfate methylated...
To analyse the population pharmacokinetics (PK) of peficitinib in patients with rheumatoid arthritis (RA) and assess potential PK covariates to identify requirement for dose adjustment RA patients.The analysis incorporated 2464 observations from 98 healthy volunteers 4919 989 patients. A model was constructed by a nonlinear mixed effect using NONMEM prior information volunteer model.A 2-compartment sequential zero- first-order absorption lag time Covariate exploration patient revealed that...
To provide a model-based prediction of individual urinary glucose excretion (UGE) effect ipragliflozin, we constructed pharmacokinetic/pharmacodynamic (PK/PD) model and population PK using pooled data clinical studies.A PK/PD for the change from baseline in UGE 24 hours (ΔUGE24h ) with area under concentration-time curve time dosing to h after administration (AUC24h ipragliflozin was described by maximum model. A also rich sampling obtained 2 pharmacology studies sparse 4 late-phase NONMEM...
各種植物の根圏および栽培土壌から分離したFusarium属菌とTrichoderma属菌について,イネの重要な種子伝染性病害であるばか苗病および苗立枯細菌病に対する発病抑制能を検討した.Fusaraum属菌350菌株,Trichoderma属菌66菌株について,培養菌液または分生子懸濁液の,イネ種子浸漬処理によるイネばか苗病発病抑制効果を検討したところ,両属とも高い発病抑制効果を示す菌株が高い割合で存在することが明らかとなった.また,ばか苗病に対して比較的低菌量処理で高い発病抑制効果を示すものの中には,イネ苗立枯細菌病に対しても高い発病抑制効果を示す菌株が多数認められた.高い発病抑制効果を示す菌株として,トマト根圏より分離したF. oxysporum SNF-356株,ノシバ根圏より分離したTrichoderma sp....
日本のサンゴ礁海域では，スキューバダイビングをはじめとする観光業や漁業などの経済活動が行われているが，その利用にあたっては異なる業種間での利害の対立や軋轢などがあり，沿岸資源管理の効率を妨げている。これまでに，日本各地でこのような対立が個別に発生し，各地で解決のための努力がなされてきたが，本研究では，これらの事例を横断的に比較することにより，両者が協調して海域の資源管理を行うためにどのような要件が必要かを明らかにすることを試みた。その結果，解決に至る共通点として①観光業者と漁業者が共同して協議会組織を設立し調整の場を設けること，②観光客（ダイバー）から利用料を徴収して保全活動を行うこと，の2点が特に有効であると考えられることがわかった。そして，この環境保全に関する料金徴収の仕組みを，類似する「生態系サービスへの支払い（payment for ecosystem services : PES）」制度と比較検討することにより，PESの概念をさらに発展的に適用することで，より効果的な沿岸生態系保全・管理スキームへと発展させ得る可能性が示唆された。
Abstract Peroxisome proliferator‐activated receptor δ (PPARδ) plays a central role in modulating mitochondrial function ischemia‐reperfusion injury. ASP1128, potent and selective modulator of PPARδ, is currently under investigation for treating acute kidney This randomized, first‐in‐human study assessed the safety, tolerability, pharmacokinetics, pharmacodynamics ASP1128 administered intravenously healthy participants. Forty‐nine participants received single dose 0.3–10 mg (n = 37) or...
Trichoderma sp....
Peficitinib pharmacokinetics and pharmacodynamics have been characterized mainly in Caucasian subjects. This study investigated the pharmacokinetics, pharmacodynamics, safety, tolerability of peficitinib healthy Japanese subjects compared with In this single-center, randomized, double-blind, placebo-controlled study, a cohort (n = 24) men received single oral dose (20, 60, or 200 mg) placebo. Another (10, 30, 100 placebo twice daily for 7 days. Pharmacokinetic pharmacodynamic parameters were...
Abstract The marketed tablet formulation of peficitinib differs from the used during clinical trials. bioequivalence and developmental tablet, food effect on formulation, were analyzed in 2 Japanese open‐label, randomized, 2‐way crossover studies healthy male volunteers. Volunteers received a single oral dose 150‐mg under fasted conditions (bioequivalence), fed or (food effect). Bioequivalence was compared with tablet. Samples for pharmacokinetic analysis collected before ≤72 hours after...
北極を含む海洋環境におけるプラスチック汚染問題に対する社会的な関心の高まりを受け，北極域におけるプラスチック汚染の研究が近年急速に進んでいる。その結果，北極におけるプラスチック汚染が広範囲に広がっていることが確認され，その汚染経路や生物に対する影響も徐々に明らかになっている。本稿では，北極のプラスチック汚染について，最新の知見をレビューし，さらに今後の展望について述べる。
Satoumi has long been practiced in Japan and is recently being promoted pursuit of sustainable integrated coastal zone management (ICZM) biodiversity conservation. considered as "a sea where high productivity conservation biological diversity are achieved through human intervention harmony with natural ecosystems." In this study, four satoumi cases were selected, Shiretoko, Ago Bay, Hinase, Nanao order to assess their effectiveness management, conservation, socioeconomic impacts. all cases,...
Anaplastic lymphoma kinase gene rearrangements (ALKr) resulting in EML4–ALK proteins occur a subset of solid tumors and are targeted by ALK inhibitors. Given the development drug resistance to inhibitors, inhibitors with different selectivity required. This phase I, non-randomized, open-label study evaluated dose-limiting toxicity (DLT), safety, pharmacokinetics, antitumor activity ASP3026, second-generation inhibitor, Japanese patients tumors. Between 1 June 2011 20 January 2014, 29...