A5012092969- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Structural Anomalies and Repair
- Aortic Disease and Treatment Approaches
- Cardiac Health and Mental Health
- Pancreatitis Pathology and Treatment
- Whipple's Disease and Interleukins
- Tracheal and airway disorders
- Microscopic Colitis
- Pain Management and Placebo Effect
- Heart Failure Treatment and Management
- Pulmonary Hypertension Research and Treatments
- Pediatric Pain Management Techniques
- Gastrointestinal Bleeding Diagnosis and Treatment
- Liver Disease and Transplantation
- Coronary Artery Anomalies
- Machine Learning in Healthcare
- Blood Pressure and Hypertension Studies
- Eosinophilic Esophagitis
- Abdominal vascular conditions and treatments
- Acute Myocardial Infarction Research
- Abdominal Surgery and Complications
- Gallbladder and Bile Duct Disorders
- Infective Endocarditis Diagnosis and Management
Azienda USL di Pescara
2024-2025
NIHR Bristol Cardiovascular Biomedical Research Unit
2019-2022
University of Bristol
2020-2022
Bristol Royal Infirmary
2021
MRC Epidemiology Unit
2020-2021
University Hospitals Bristol NHS Foundation Trust
2019
National Health Service
2019
Patients with repaired Tetralogy of Fallot (rToF) typically report having preserved subjective exercise tolerance. Chronic pulmonary regurgitation (PR) varying degrees right ventricular (RV) dilation as assessed by cardiac magnetic resonance imaging (MRI) is prevalent in rToF and may contribute to clinical compromise. Cardiopulmonary testing (CPET) provides an objective assessment functional capacity, the International Physical Activity Questionnaire (IPAQ) can provide additional data on...
Background Tetralogy of Fallot repair results in late occurrence pulmonary regurgitation, which requires valve replacement a large proportion patients. Both homografts and bioprostheses are used for as uncertainty remains on prosthesis should be considered superior. We performed long-term imaging clinical comparison between these 2 strategies. Methods Results compared echocardiographic follow-up data 209 patients with previous tetralogy who underwent homograft (n=75) or bioprosthesis (n=134)...
There is little known about how payer status impacts clinical outcomes in a universal single-payer system such as the UK National Health Service (NHS). The aim of this study was to evaluate relationship between (private or public) and following cardiac surgery from NHS providers England.The Adult Cardiac Surgery Audit (NACSA) registry interrogated for patients who underwent adult England 2009 2018. Information on socioeconomic were provided by linkage with Iteration English Indices...
Several studies have suggested a variation of myocardial tolerance to ischaemia depending on the daytime surgery. To test this hypothesis, we conducted three-level analysis: metaanalysis, national patient-level dataset analysis and post-hoc trial analysis. We first performed systematic review metaanalysis available comparing clinical outcomes following cardiac surgery in morning (am) versus afternoon (pm). Then, interrogated UK adult audit database (NACSA) analysed am or pm patients...
Background Following the repair of TOF patients may be left with pulmonary regurgitation and a dilated right ventricle (RV), which in turn can lead to ventricular arrhythmias sudden death. A prolonged QRS is predictor arrhythmias. However, whether subsequent valve replacement (PVR) reverse QRS-prolongation controversial. We hypothesized that changes duration following PVR are determined by preoperative QRS-duration RV volumes Methods retrospective single-center cohort study was conducted on...
Objective Independent temporal external validation of the improving partial risk adjustment in surgery model (PRAIS-2) to predict 30-day mortality patients undergoing paediatric cardiac surgery. Design Retrospective analysis prospectively collected data. Setting Paediatric Intervention PRAIS-2 was carried out using a two temporally different single centre (Bristol, UK) cohorts: Cohort 1 undertaken from April 2004 March 2009 and 2 2015 July 2019. For each subject score calculated according...
Aims Biliary stones are an endemic condition, affecting 20% of the population. In up to cases, gallstones associated with common bile duct (CBDS), which may cause symptoms and complications. The management CBDS is still controversial. aim our study compare laparoendoscopic rendezvous (RV) endoscopic retrograde cholangiopancreatography (ERCP) treat cholecystocholedocholithiasis using a large cohort patients.
Abstract Background Tetralogy of Fallot (TOF) repair results in long term chronic pulmonary regurgitation requiring valve replacement (PVR). Homograft and stented bio-prosthesis are currently used for PVR but whether one should be considered superior to another remains unknown. Aim To compare echocardiographic clinical outcomes after with vs bioprosthesis patients previous TOF repair. Methods 137 who underwent bioproshesis were compared 80 received an homograft using Mixed linear model...
ABSTRACT Objective Risk stratification in paediatric patients undergoing heart surgery remains a challenge. The improving partial risk adjustment (PRAIS2) is model predicting 30-day mortality which has been recently developed and validated using UK-based cohort from April 2009-March 2015. We aimed to perform an independent temporal external validation explore its generalisability clinical utility. Methods PRAIS2 was carried out single centre (Bristol, UK) 2004 March 2009 2015 July 2019. For...
Background: Several studies have suggested a variation of myocardial tolerance to ischaemia depending on the daytime surgery. To test this hypothesis, we conducted three-level analysis: meta-analysis, national patient-level dataset analysis and post-hoc trial analysis. Methods: We first performed systematic review meta-analysis available comparing clinical outcomes following cardiac surgery in morning (am) versus afternoon (pm). Then, interrogated UK adult audit database (NACSA) analysed am...
Abstract Background: To determine the association between having a CHD compared with not, on educational attainment in adults. A systematic review and meta-analysis Method : Studies were eligible if they reported rate/odds/proportion of level adults by history CHD. Result Out 1537 articles screened, we identified 11 (N = 104585 participants, 10487 CHD), 10(N 167470 11820 8 150813 9817 CHD) studies reporting information university education, secondary vocational training, respectively both...