A5088870412- Advanced biosensing and bioanalysis techniques
- Advanced Biosensing Techniques and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Fluorescence Microscopy Techniques
- DNA and Nucleic Acid Chemistry
- Plasmonic and Surface Plasmon Research
- Photonic and Optical Devices
- RNA Interference and Gene Delivery
Eindhoven University of Technology
2024
Sapienza University of Rome
2020
Single-molecule fluorescence has revealed a wealth of biochemical processes but does not give access to submillisecond dynamics involved in transient interactions and molecular dynamics. Here we overcome this bottleneck demonstrate record-high photon count rates >10
Multivalency as an interaction principle is widely utilized in nature. It enables specific and strong binding by multiple weak interactions through enhanced avidity a core process immune recognition cellular signaling, which also current concept drug design. Here, we use the high signals from plasmon-enhanced fluorescence of nanoparticles to extract kinetics dynamics multivalent on single-molecule level real time. We study mono-, bi-, trivalent using DNA Holliday Junction model construct...
Intracluster bonds in hyperbranched DNA polymers prevent percolation transition.