Giulia Noaro
A5004836218- Pancreatic function and diabetes
- Diabetes Management and Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Diabetes Treatment and Management
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Colorectal and Anal Carcinomas
- Esophageal and GI Pathology
- Hernia repair and management
- Appendicitis Diagnosis and Management
- Colorectal Cancer Surgical Treatments
- Diabetes and associated disorders
- Organ Transplantation Techniques and Outcomes
- Liver physiology and pathology
- Genetic factors in colorectal cancer
- Liver Disease and Transplantation
- Gallbladder and Bile Duct Disorders
- COVID-19 Clinical Research Studies
- Inflammatory mediators and NSAID effects
- SARS-CoV-2 and COVID-19 Research
- Metastasis and carcinoma case studies
- Viral-associated cancers and disorders
University of Padua
2011-2024
AULSS 2 Marca Trevigiana
2023-2024
Ospedale Castelfranco Veneto
2021
Edinburgh Royal Infirmary
2019
University of Edinburgh
2019
Istituto Oncologico Veneto
2014-2015
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2015
Azienda Ospedaliera di Padova
2014
Objective: This paper aims at proposing a new machine-learning based model to improve the calculation of mealtime insulin boluses (MIB) in type 1 diabetes (T1D) therapy using continuous glucose monitoring (CGM) data. Indeed, MIB is still often computed through standard formula (SF), which does not account for rate-of-change (ΔG), causing critical hypo/hyperglycemic episodes. Methods: Four candidate models calculation, on multiple linear regression (MLR) and least absolute shrinkage selection...
Mealtime insulin dosing is a major challenge for people living with type 1 diabetes (T1D). This task typically performed using standard formula that, despite containing some patient-specific parameters, often leads to sub-optimal glucose control due lack of personalization and adaptation. To overcome the previous limitations here we propose an individualized adaptive mealtime bolus calculator based on double deep Q-learning (DDQ), which tailored patient thanks procedure relying two-step...
The purpose of this case-control study was to evaluate the impact hybrid minimally invasive esophagectomy for cancer on surgical stress response and nutritional status. All 34 consecutive patients undergoing at our unit between 2008 2013 were retrospectively compared with open gastric tubulization (open), matched neoadjuvant therapy, pathological stage, gender age. Demographic data, tumor features postoperative course (including quality life systemic inflammatory status) compared....
Prognostic assessment of patients with hepatocellular carcinoma (HCC) at the time diagnosis remains controversial and becomes even more complex restaging when new variables need to be considered. The aim current study was evaluate prognostic utility before proceeding additional therapies for HCC. Two independent Italian prospective databases were used identify 1,196 (training cohort) 648 (validation consecutive HCC treated over same period (2008-2015) who had complete decisions about...
Long-term daily use of aspirin reduces incidence and mortality due to colorectal cancer (CRC). This study aimed analyze the effect on tumor microenvironment, systemic immunity, healthy mucosa surrounding cancer.
Since the beginning of pandemic due to novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its related disease, disease 2019 (COVID-19), several articles reported negative outcomes in surgery infected patients. Aim this study is report results patients with COVID-19-positive swab, perioperative period after surgery. Data undergoing emergent or oncological surgery, were collected a retrospective, multicenter study, which involved 20 Italian institutions. Collected...
Background: Inguinal hernioplasty is the most frequently performed operation in Western world today. Although laparoscopic approach for inguinal hernia repair has shown excellent results terms of complications and recurrences, anterior still used. Postoperative pain recurrences are widely studied both approaches, but there little information about often more troublesome rare surgery their treatment. Methods: In period from January 1, 2014 to December 31, 2019, 1874 operations were with...
In persons with type 1 diabetes (T1D) insulin dosing can be adjusted based on trend arrows derived from continuous glucose monitoring (CGM). We propose a slide rule narrower blood intervals and more classes of sensitivity than are available in current models. The was tested silico, which meal simulated 100 virtual subjects the bolus calculated either standard way insulin-to-carbohydrate ratio correction factor or according to rule, following percentage time spent range (70–180 mg/dl; %TIR),...
The aim of this study was to evaluate the impact jejunostomy during esophagectomy for cancer on postoperative health-related quality life (HRQL).We all consecutive patients who underwent at surgical oncology unit Veneto Institute Oncology (IOV-IRCCS) between January 2008 and March 2014. primary outcome HRQL, which assessed using nine scales EORTC C30 OES18 questionnaires. General linear models were estimated mean score difference (MD) each selected scale in with without jejunostomy,...
Colon cancer in young patients is often associated with hereditary syndromes; however, early-onset rectal cancer, mutations of these genes are rarely observed. The aim this study was to analyse the features local immune microenvironment and mutational pattern cancer.Commonly mutated were analysed within a series from University Hospital Padova. Mutation frequency gene expression cohort Cancer Genome Atlas ('TCGA') compared immune-cell infiltration levels healthy mucosa adjacent cancers...
Type 1 diabetes (T1D) therapy requires multiple daily insulin injections to compensate the lack of endogenous production due β-cells destruction. An empirical standard formula (SF) is commonly used for such a task. Unfortunately, SF does not include information on glucose dynamics, e.g. rate-of-change (ROC) provided by continuous monitoring (CGM) sensor. Hence, can sometimes lead under/overestimations that cause critical hypo/hyperglycemic episodes during/after meal. Recently, overcome this...
Background: Providing real-time magnitude and direction of glucose rate-of-change (ROC) via trend arrows represents one the major strengths continuous monitoring (CGM) sensors in managing type 1 diabetes (T1D). Several literature methods were proposed to adjust standard formula (SF) used for insulin bolus calculation by accounting ROC, but each them provides different suggestions, making it difficult understand which should be applied practice. This work aims at performing an extensive...
One of the major problems related to type 1 diabetes (T1D) management is hypoglycemia, a condition characterized by low blood glucose levels and responsible for reduced quality life increased mortality. Fast-acting carbohydrates, also known as hypoglycemic treatments (HT), can counteract this event. In literature, dosage timing HT are usually based on heuristic rules. present work, we propose an algorithm mitigating hypoglycemia suggesting preventive consumption, with dosages determined...
Lynch syndrome is rarely associated with rectal cancer (RC) and thus, metachronous RC has been scarcely investigated. This study aimed to analyze the mucosal immune microenvironment in sporadic RC. We analyzed 25 RCs present IMMUNOREACT 1 2 multicentre observational studies (624 patients). A panel of markers was retrospectively investigated at immunohistochemistry: CD3, CD4, CD8, CD8b, Tbet, FoxP3, PD-L1, MSH6, PMS2 CD80. Single-cell suspensions were subjected flow-cytometry determine...