A5016283413- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- SARS-CoV-2 and COVID-19 Research
- Epigenetics and DNA Methylation
- COVID-19 Clinical Research Studies
- Cell Image Analysis Techniques
- vaccines and immunoinformatics approaches
- Cell death mechanisms and regulation
- RNA modifications and cancer
- Developmental Biology and Gene Regulation
- Animal Genetics and Reproduction
- Circular RNAs in diseases
- Single-cell and spatial transcriptomics
- COVID-19 Impact on Reproduction
University of Lausanne
2024-2025
SIB Swiss Institute of Bioinformatics
2024
Pwani University
2022-2023
ABSTRACT Although it is well established that certain stages of development are more conserved than others, the reasons for this phenomenon remain largely unknown. We study molecular conservation in an organ, molar, by comparing temporal profiles expression mice and hamsters. find molar characterized a rarely observed pattern level coding sequences forming inverse hourglass, with at beginning end morphogenesis intermediate stages. As rodent described, we were able to link properties...
Abstract Background The COVID-19 pandemic caused by SARS-CoV-2 has spread rapidly across the continents. While incidence of been reported to be higher among African-American individuals, rate mortality lower compared that non-African-Americans. ACE2 is involved in as uses enzyme enter host cells. Although difference can explained many factors such low accessibility health insurance community, little known about expression patients non-African-American patients. variable genes contribute this...
Abstract Epilepsy is a neurological disease defined by episodes of synchronous convulsions. Recently, miRNAs have been proven as promising biomarkers for multiple ailments like tumors and neurodegenerative disorders; their role in epilepsy still unclear. This study aimed to understand the involvement detect potential treatment epilepsy. RNA transcripts, miRNA from brain tissue plasma small extracellular vesicle samples epileptogenic patients 6 different studies downloaded NCBI sequence read...
Bgee (https://www.bgee.org/) is a database to retrieve and compare gene expression patterns in multiple animal species. Expression data are integrated made comparable between species thanks consistent annotation processing. In the past years, we have single-cell RNA-sequencing into through careful curation of public datasets We fully this new technology along with wealth other existing Bgee. As result, can now provide one definitive answer all way cell resolution about gene's pattern,...
Phylogenetic analysis is one of the most reliable and important analyses in bioinformatics. Currently, many phylogenetic tools can be used for visualization interpretation biological data. However, a lot technical expertise required order to use these tools. It challenging biologists have deal with this issue. This study therefore compared three multipurpose informed on their features so as help user choose appropriate tool research resources, especially those who want do bioinformatics...
Background: Breast cancer, a leading cause of cancer-related deaths among women globally, is particularly prevalent in Kenya, where approximately 6,000 new cases are diagnosed annually. While the role apoptosis cancer development well-documented, extent dysregulation apoptotic genes Kenyan breast remains understudied. This study aimed to analyze gene expression tumor and adjacent normal tissues from with based on population, age, subtypes, stage at diagnosis by conducting comparative...