Adults with GH deficiency (GHD) have a decreased life expectancy. The effect of treatment on mortality remains to be established.This nationwide cohort study investigates the all-cause and cause-specific analyzes patient characteristics influencing in GHD adults.Patients Dutch National Registry Growth Hormone Treatment were retrospectively monitored (1985-2009) subdivided into (n = 2229), primary (untreated, n 109), secondary control (partly treated, 356) groups.Standardized ratios (SMR)...

Numerous studies have investigated the effect of serum IGF-I concentration on aging and different aging-related diseases, e.g. cardiovascular disease (CVD) cancer. Decreased as well increased levels been reported to be associated with reduced life expectancy in humans.This study investigates association all-cause cause-specific mortality community-dwelling older persons development CVD cancer.Data were used from Longitudinal Aging Study Amsterdam (LASA), an ongoing multidisciplinary cohort...

Radiotherapy is frequently administered as adjuvant treatment in patients with clinically nonfunctioning pituitary adenomas (NFPAs). However, concerns have been raised about potential long-term side effects, including cerebrovascular events (CVEs) and secondary intracranial tumors. The aim of this study was to analyze the risk CVEs, tumors, mortality irradiated (IRR) NFPA patients, compared who were not (non-IRR). cohort included 806 a from Dutch National Registry Growth Hormone Treatment...

The availability of various first-line treatment modalities for acromegaly and evolving surgical techniques emphasize the need accurately defined predictors outcome. We retrospectively analysed outcome 30 patients with after initial endoscopic transsphenoidal surgery in two university hospitals from 2001 until 2009, reviewed comparable literature investigating predictive tumor characteristics. Medical records were monitored patient Each pituitary magnetic resonance imaging (MRI) scan was...

Objective High as well low levels of IGF1 have been associated with cardiovascular diseases (CVD). The relationship (components of) the metabolic syndrome could help to clarify this controversy. aims study were: i) investigate association concentration prevalent syndrome; and ii) examine role in between incident CVD during 11 years follow-up. Methods Data were used from Longitudinal Aging Study Amsterdam, a cohort representative sample Dutch older population (≥65 years). available 1258...

GH replacement therapy (GH-RT) is a widely accepted treatment in GH-deficient adults with nonfunctioning pituitary adenoma (NFPAs). However, some concerns have been raised about the safety of GH-RT because its potentially stimulating effect on tumor growth.The aim this study was to evaluate progression NFPA patients using GH-RT.From Dutch National Registry Growth Hormone Treatment Adults, nationwide surveillance severely (1998-2009), all ≥ 30 days were selected (n = 783). Data...

The aim of the present study was to investigate effect low-normal and high-normal levels IGF-1 in growth hormone (GH) deficient adults on cognition wellbeing during GH treatment.A randomized, open-label, clinical trial including 32 subjects receiving therapy for at least 1 year. Subjects were randomized receive either a decrease (IGF-1 target level - 2 SDS) or an increase their daily dose period 24 weeks. Memory measured by Cambridge Neuropsychological Test Automated Battery, selecting...

Abstract Objective Given the previously identified sex differences in cardiovascular (CV) morbidity and mortality patients with growth hormone deficiency (GHD) receiving GH replacement therapy (GHRT), our aim is to investigate sex-specific efficacy of (long-term) GHRT on CV risk profile disease subjects GHD. Our hypothesis that women will experience less beneficial effects than men. Design Retrospective nationwide cohort study. Methods We compared all men (n = 1335) 1251) severe GHD...

Objective The Dutch National Registry of GH Treatment in Adults was established 1998 as an initiative the Ministry Health. main goals were to gain more insight into long-term efficacy, safety, and costs therapy (GHT) adult GH-deficient (GHD) patients Netherlands. Methods Baseline patient characteristics diagnostic test procedures evaluated. Results Until January 2009 roughly 10 years, 2891 (1475 men 1416 women, mean age 43.5±16.5 years) registered. GHD childhood-onset (CO) over 20% isolated...

The primary aim of the current study was to objectify a spectrum persisting subjective psychological complaints in patients with hypopituitarism, at least six months after normalizing hormonal disturbances. Also, gender differences on these outcomes were investigated. secondary identify illness perceptions and causal attributions within this patient group.A total 42 adult participants (60% females) treated hypopituitarism once filled out number questionnaires. Profile Mood States (POMS)...

The effect of GH deficiency (GHD) on the metabolic profile acromegaly patients is unclear in previously treated for acromegaly, as are efficacy and safety treatment this particular group. aim study to describe characteristics with severe GHD who were investigate effects long-term cardiovascular risk factors morbidity, compared a nonfunctioning pituitary adenoma (NFPA).A nationwide surveillance study.Sixty-five from Dutch National Registry Growth Hormone Treatment Adults previous 778 NFPA....

Objective Isolated GH deficiency (IGHD) could provide a model to investigate the influence of per se and effect replacement therapy without from other pituitary hormone deficiencies or their treatment. The aim this study is address questions about differences between IGHD multiple (MPHDs) in clinical presentation responsiveness Design A nationwide surveillance was carried out describe difference treatment patients with MPHDs. Methods Dutch National Registry Treatment Adults founded 1998 gain...

The effects of growth hormone (GH) replacement therapy on fracture risk in adult GH deficient (GHD) patients with different etiologies pituitary GHD are not well known, due to limited data. aim this study was investigate characteristics and occurrence at start (baseline) during long-term adults previously treated for Cushing's disease (CD) or acromegaly, compared previous nonfunctioning adenoma (NFPA).From the Dutch National Registry Growth Hormone Treatment Adults, a nationwide surveillance...

Abstract Context Previous studies report that outcomes of growth hormone (GH) replacement therapy (GHRT) might be less beneficial in deficient (GHD) women compared with men. Objective This study investigated possible contributing factors regarding this previously found sex difference. Methods retrospective cohort study, conducted at a nationwide outpatient clinic (the Dutch National Registry GH Treatment Adults), included adult GHD men (n = 1335) and 1251) treated GHRT. The patients’...

<b><i>Background/Aims:</i></b> It is unknown whether long-term growth hormone replacement therapy (GHRT) affects body composition in an age- or sex-dependent manner. We aimed to study the effects of 4 years GHRT on a large cohort patients with hypopituitarism compared reference population matched by age and sex. <b><i>Methods:</i></b> A total 964 GH-deficient adults from KIMS (Pfizer International Metabolic Database) adult-onset...