A5001082530- Cancer-related cognitive impairment studies
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- Psychosomatic Disorders and Their Treatments
- Lung Cancer Research Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Gambling Behavior and Treatments
- Posttraumatic Stress Disorder Research
- Cognitive Abilities and Testing
- Traumatic Brain Injury Research
- Personality Disorders and Psychopathology
- Eating Disorders and Behaviors
- Obsessive-Compulsive Spectrum Disorders
- Dementia and Cognitive Impairment Research
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Multisensory perception and integration
- Gastrointestinal motility and disorders
- EEG and Brain-Computer Interfaces
- Child Abuse and Trauma
- Cancer survivorship and care
The Netherlands Cancer Institute
2016-2025
Netherlands Federation of University Medical Centres
2023
Nederlandse Vereniging voor Anesthesiologie
2023
Oncode Institute
2022
Amsterdam Neuroscience
2021
Amsterdam University Medical Centers
2021
University of Amsterdam
2010-2021
Northern Kentucky University
2019
Highland Community College - Illinois
2019
Innsbruck Medical University
2019
The primary aim of this study was to examine how response inhibition is reflected in components the event-related potential (ERP), using stop-signal paradigm as a tool manipulate processes. Stop signals elicited sequence N2/P3 that partly overlapped with ERP by reaction stimulus. were more pronounced on trials than no-stop-signal trials. At Cz, P3 peaked earlier successful unsuccessful stop This finding extends horse race model demonstrating internal signal (as P3) not constant, but...
ABSTRACT Abnormal cue reactivity is a central characteristic of addiction, associated with increased activity in motivation, attention and memory related brain circuits. In this neuroimaging study, problem gamblers (PRG) was compared heavy smokers (HSM) healthy controls (HC). A functional magnetic resonance imaging event‐related paradigm, consisting gambling, smoking‐related neutral pictures, employed 17 treatment‐seeking non‐smoking PRG, 18 non‐gambling HSM, HC. Watching gambling pictures...
Chemotherapy is associated with cognitive impairment in a subgroup of breast cancer survivors, but the neural circuitry underlying this side effect largely unknown. Moreover, long-term has not been studied well. In present study, functional magnetic resonance imaging (fMRI) and neuropsychological testing were performed survivors almost 10 years after high-dose adjuvant chemotherapy (chemo group, n = 19) for whom had indicated (control 15). BOLD activation performance measured during an...
Abstract The neural substrate underlying cognitive impairments after chemotherapy is largely unknown. Here, we investigated very late (>9 years) effects of adjuvant high‐dose on brain white and gray matter in primary breast cancer survivors ( n = 17) with multimodal magnetic resonance imaging (MRI). A group who did not receive was scanned for comparison 15). Neuropsychological tests demonstrated the group. Diffusion tensor (DTI) tract‐based spatial statistics showed that associated focal...
Article AbstractObjective: Classic posttraumatic stress disorder (PTSD) is associated with smaller hippocampus, amygdala, and anterior cingulate cortex (ACC) volumes. We investigated whether child abuse-related complex PTSD—a severe form of PTSD affect dysregulation high comorbidity—showed similar brain volume reductions. Method: used voxel-based morphometry to measure gray matter concentrations in referred outpatients (n = 31) compared matched healthy nontraumatized controls 28). Complex...
Behavioral addictions like pathological gambling share many clinical characteristics with substance dependence. In addition, both types of disorders are associated impairments in inhibitory control. Studies patients use point to hyporesponsiveness the dorsomedial prefrontal cortex. However, no such data exist on behavioral addictions.Using functional magnetic resonance imaging, we investigated neural circuitry impaired response inhibition a group male problem gamblers (n=17) using stop...
Alcohol use disorders (AUDs) are associated with smaller grey matter volumes in cortical and subcortical brain regions which related to cognitive impairments often found these disorders. Similar have been patients suffering from problem gambling behaviour. However, contrast AUDs, behaviour does not entail exposure toxic agents. Although there many clinical, neuropsychological, neurobiological similarities between PG substance it has yet established whether pathological gambling, similar...
Neurodegeneration is the main cause for permanent disability in multiple sclerosis. The effect of current immunomodulatory treatments on neurodegeneration insufficient. Therefore, direct neuroprotection and myeloprotection remain an important therapeutic goal. Targeting acid-sensing ion channel 1 (encoded by ASIC1 gene), which contributes to excessive intracellular accumulation injurious Na+ Ca2+ over-expressed acute sclerosis lesions, appears be a viable strategy limit cellular injury that...
Objectives To date, only four small studies have investigated the effects of adjuvant chemotherapy for breast cancer on microstructure cerebral white matter with magnetic resonance imaging (MRI). These studies, which were conducted shortly up to 10 years post‐treatment, showed that is associated focal loss microstructural integrity. We long‐term effect integrity by comparing brains chemotherapy‐exposed survivors those a population‐based sample women without history cancer. Experimental...
An increasing body of literature indicates that chemotherapy (ChT) for breast cancer (BC) is associated with adverse effects on the brain. Recent research suggests cognitive and brain function in patients BC may already be compromised before start chemotherapy. This first study combining neuropsychological testing, patient-reported outcomes, multimodal magnetic resonance imaging (MRI) to examine pretreatment cognition various aspects structure a large sample. Thirty-two scheduled receive ChT...
Abstract Background Up to 60% of breast cancer patients treated with chemotherapy is confronted cognitive problems, which can have a significant impact on daily activities and quality life (QoL). We investigated whether exercise training improves cognition in chemotherapy-exposed 2–4 years after diagnosis. Methods Chemotherapy-exposed patients, both self-reported problems lower than expected performance neuropsychological tests, were randomized an or control group. The 6-month intervention...
Glucocorticoids (GCs, cortisol in human) are associated with impairments declarative memory retrieval. Brain regions hypothesized to mediate these effects the hippocampus and prefrontal cortex (PFC). Our aim was use fMRI localizing of GCs during Therefore, we tested retrieval 21 young healthy males a randomized placebo-controlled crossover design. Participants encoded word lists containing neutral emotional words 1 h prior ingestion 20 mg hydrocortisone. Memory using an old/new recognition...
Post-traumatic stress disorder (PTSD) is associated with impaired memory performance coupled functional changes in brain areas involved declarative and emotion regulation. It not yet clear how symptom severity comorbidity affect neurocognitive functioning PTSD. We performed a magnetic resonance imaging (fMRI) study an emotional task 28 Complex PTSD patients comorbid depressive personality disorders, 21 healthy non-trauma-exposed controls. In patients—compared to controls—encoding of later...
Cancer- and treatment-related cognitive changes have been a focus of increasing research since the early 1980s, with meta-analyses demonstrating poorer performance in cancer patients domains including executive functions, processing speed, memory. To facilitate collaborative efforts, 2011 International Cognition Cancer Task Force (ICCTF) published consensus recommendations for core neuropsychological tests studies populations. Over past decade, used neuroimaging techniques, structural...
Background Functional neuroimaging studies have shown increased Stroop interference coupled with altered anterior cingulate cortex (ACC) and insula activation in post-traumatic stress disorder (PTSD). These brain areas are associated error detection emotional arousal. There is some evidence that treatment can normalize these patterns. Method At baseline, we compared classic performance blood oxygenation level-dependent responses (functional magnetic resonance imaging) of 29 child...
Background. Memory functioning has been highlighted as a central issue in pathological dissociation. In non-pathological dissociation, evidence for enhanced working memory found, together with greater task-load related activity. So far, no imaging studies have investigated dissociative patients. Method. To assess patients functional magnetic resonance was used during performance of parametric, verbal working-memory task disorder ( n =16) and healthy controls =16). Results. Imaging data...
Chemotherapy (CT) is associated with adverse effects on cognition. Only few studies have investigated cognition in testicular cancer (TC) patients and very late of CT are absent. Further, brain changes relation to treatment not been TC. The objective the present study compare psychosocial functioning, cognitive performance (micro)structure following surgery for TC, against (S)-only.Twenty-eight (43.1±7.5 y) 23 S-only (48.2±9.5y) TC survivors average 14 yr post-treatment were examined using...