A5000320980- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Neuroscience of respiration and sleep
- Misinformation and Its Impacts
- Pharmaceutical industry and healthcare
- Esophageal Cancer Research and Treatment
- Memory and Neural Mechanisms
- Oral Health Pathology and Treatment
- Social Media in Health Education
- Autoimmune and Inflammatory Disorders
- Antibiotic Use and Resistance
- Obesity and Health Practices
- Child and Adolescent Health
- Connexins and lens biology
- Primary Care and Health Outcomes
- Cancer and Skin Lesions
- Lung Cancer Treatments and Mutations
- Circadian rhythm and melatonin
- Lung Cancer Diagnosis and Treatment
- Olfactory and Sensory Function Studies
- Patient Satisfaction in Healthcare
- Patient-Provider Communication in Healthcare
University of Arkansas for Medical Sciences
2007-2024
General Department of Preventive Medicine
2024
Milken Institute
2022
George Washington University
2022
University of California, San Diego
2010
This review considers recent evidence showing that cells in three regions of the reticular activating system (RAS) exhibit gamma band activity, and describes mechanisms behind such manifestation. Specifically, we discuss how mesopontine pedunculopontine nucleus (PPN), intralaminar parafascicular (Pf), pontine Subcoeruleus dorsalis (SubCD) all fire beta/gamma range when maximally activated, but no higher. The this ceiling effect have been recently elucidated. We describe findings every cell...
We recorded the effects of administration stimulant Modafinil on amplitude sleep state-dependent auditory P13 evoked potential in freely moving rats, a measure arousal thought to be generated by cholinergic arm reticular activating system, specifically pedunculopontine nucleus (PPN). Groups rats were implanted for recording responses and intracranial injections into PPN neuroactive agents determined. The showed that increased dose-dependent manner at doses 100, 200, 300 µM. effect was...
Abstract The pedunculopontine nucleus (PPN), the cholinergic arm of reticular activating system, regulates waking and rapid eye movement sleep. Here, we demonstrate immunohistochemical labeling leptin receptor signaling isoform in PPN neurons, investigated effects G‐protein modulation triple antagonist (TA) on action PPN. Whole‐cell patch clamp recordings were performed rat brainstem slices from 9 to 17 day old pups. Previous results showed that caused a partial blockade sodium (I Na )...
Abstract Most psychiatric and neurological disorders exhibit sleep disorders, in some cases presage the disease. Study of control waking has potential for making a major impact on number translational neuroscience research this area critical. One element reticular activating system (RAS) is pedunculopontine nucleus (PPN), which cholinergic arm RAS, projects to thalamus trigger thalamocortical rhythms brainstem modulate muscle tone locomotion. We developed program using slices containing PPN...
Rapid eye movement sleep decreases dramatically during development. We tested the hypothesis that some of this decrease may be due to GABAergic inhibition reticular activating system neurons. Recordings pedunculopontine neurons in vitro showed γ-amino-butyric acid, receptor agonist muscimol depolarized noncholinergic cells early developmental rapid sleep, and hyperpolarized them later. Most cholinergic were throughout period tested. The acid b baclofen both cells, although degree...
Storylines of Family Medicin e is a 12-part series thematically linked mini-essays with accompanying illustrations that explore the many dimensions family medicine as interpreted by individual physicians and medical educators in USA elsewhere around world. In ‘VII: across lifespan’, authors address following themes: ‘Family maternity care’, ‘Seeing children patients brings joy to work’, care adolescents’, ‘Reproductive healthcare ‘Men’s health’, ‘Care older adults’, ‘Being dying’. May...
Lichen planus has been associated with several precipitating factors, such as drugs, immunizations, and viral infections, including hepatitis C virus (HCV). Eruptive or disseminated lichen is a rare variation that most often presents an acute, widespread exanthem progresses rapidly usually lasts for shorter duration. This not well studied, little known about the etiologies treatments of this form. Thus far, only few cases eruptive have reported to be HCV infection. We report case 62-year-old...
The overuse of antibiotics has rapidly made antimicrobial resistance a global public health challenge. There is an emerging trend where providers who perceive that their patients expect are more likely to prescribe unprompted or upon request. Particularly, care have expressed concern dissatisfied will provide disparaging online reviews, therefore threatening the reputation practice. To better deal with negative reviews and inform patients, some staff directly respond patients' feedback....
<sec> <title>BACKGROUND</title> The overuse of antibiotics has rapidly made antimicrobial resistance a global public health challenge. There is an emerging trend where providers who perceive that their patients expect are more likely to prescribe unprompted or upon request. Particularly, care have expressed concern dissatisfied will provide disparaging online reviews, therefore threatening the reputation practice. To better deal with negative reviews and inform patients, some staff directly...