A5046045332- Lipid Membrane Structure and Behavior
- Pancreatic function and diabetes
- Innovations in Medical Education
- Cellular transport and secretion
- Endoplasmic Reticulum Stress and Disease
- Muscle Physiology and Disorders
- Nanoparticle-Based Drug Delivery
- Adenosine and Purinergic Signaling
- Career Development and Diversity
- Diversity and Career in Medicine
- Neuroscience and Neuropharmacology Research
- Erythrocyte Function and Pathophysiology
- Advanced Fluorescence Microscopy Techniques
- Advanced Electron Microscopy Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- 3D Printing in Biomedical Research
- Polyomavirus and related diseases
- Medical Education and Admissions
- Tuberous Sclerosis Complex Research
- Primary Care and Health Outcomes
- Signaling Pathways in Disease
- Advanced Thermodynamics and Statistical Mechanics
- Metalloenzymes and iron-sulfur proteins
- Consumer Attitudes and Food Labeling
- Advanced Thermoelectric Materials and Devices
Oakland University
2022-2024
Michigan United
2024
Pioneer (United States)
2023
Wayne State University
2015-2021
University of Pennsylvania
2019
Montreal Neurological Institute and Hospital
2019
McGill University
2019
Czech Academy of Sciences, Institute of Physiology
2019
Despite recent advances in thermometry, determination of temperature at the nanometer scale single molecules to live cells remains a challenge that holds great promise disease detection among others. In present study, we use new approach thermometry with spatial and thermal resolution 80 nm 1 mK respectively, by directly associating 2 cadmium telluride quantum dots (CdTe QDs) subject under study. The CdTe QDs physically adhered bovine cardiac rabbit skeletal muscle myosin, enabling heat...
To identify whether factors toxic to oligodendrocytes (OLs), released by B cells from patients with MS, are found in extracellular microvesicles enriched exosomes.
Exosomes are a class of small, secreted extracellular vesicles (EV) that have recently gained considerable attention for their role in normal cellular function, disease processes and potential as biomarkers. serve intercellular messengers carry molecular cargo can alter gene expression the phenotype recipient cells. Here, we investigated alterations microRNA exosomes by epileptogenic tissue tuberous sclerosis complex (TSC), multi-system genetic disorder includes brain lesions known tubers....
Abstract Supramolecular cup-shaped lipoprotein structures called porosomes embedded in the cell plasma membrane mediate fractional release of intravesicular contents from cells during secretion. The presence porosomes, have been documented many types including neurons, acinar exocrine pancreas, GH-secreting pituitary, and insulin-secreting pancreatic β-cells. Functional reconstitution into artificial lipid membranes, also accomplished. Earlier studies on mouse Min6 report 100-nm porosome...
Ions greatly influence protein structure-function and are critical to health disease. A 10, 000-fold higher calcium in the sarcoplasmic reticulum (SR) of muscle suggests elevated levels near active channels at SR membrane impact localized high on motor myosin. In current study, combined quantum dot (QD)-based nanothermometry circular dichroism (CD) spectroscopy enabled detection previously unknown enthalpy changes associated structural remodeling myosin, impacting its function following...
Current approaches in regenerative medicine to develop human skeletal muscle replicating native tissue for engrafts and high-throughput drug screening gene therapy are still their infancy have not proven recapitulate the behavior regulatory processes present endogenous tissue. This stems at least part from lack of a comprehensive understanding emergent properties vitro growth development. To address this gap our current knowledge, we developed stretchable micropatterned 3D platform that...
Abstract Expansion microscopy (ExM) involves the use of hydration-competent polymers to physically expand biological specimens approximately 4-fold linear increase achieve 70 nanometer resolution using an ordinary diffraction limited optical microscope. Optimal conditions however for antigen retention during expansion process and relative between organelles within cells has remained unclear. It is reported that different tissues extents, suggesting although isotropic believed occur,...
The cell plasma membrane is a highly dynamic organelle governing wide range of cellular activities including ion transport, secretion, division, growth, and development. fundamental process involved in the addition new membranes to pre-existing membranes, however, unclear. Here, we report, using biophysical, morphological, biochemical, molecular simulations, selective incorporation proteins lipids from cytosol into dictated by stretch composition. Stretching as consequence volume increase...
We describe how we integrated guided learning teaching modules in an enrichment program for high school students with the aim of enhancing their knowledge and skills to empower them take charge own health risks well-being.
Introduction: Backward design, an instructional model outlined by Wiggins and McTighe, emphasizes identifying key learning outcomes (LOs) that students must be able to perform after about a topic. It requires educators first develop authentic assessments aligned with the LOs, which form basis of course content activities. The majority medical across United States encounter lecture-based in their two years basic sciences curriculum little opportunity for hands-on training build on necessary...
Educational experiences available to high school students have the potential provide learning opportunities within science, technology, engineering, mathematics, and medicine (STEMM) that lead student success in college beyond. Therefore, goal of our research was identify whether participation STEMM-specific outreach pathway programs (OPPs), advanced placement/international baccalaureate (AP/IB), or dual enrollment correlate with self-directed (SDL) skills. Our population is composed recent...
Introduction College readiness encompasses many different domains, including content knowledge, metacognitive skills, communication learning strategies, and transitional knowledge. impacts academic achievement; moreover, student perceptions regarding college impact their behavior decision to attend college. High-achieving students from lower socioeconomic status (SES) areas possess grit intelligence, but systemic barriers inequities can interfere with the achievement of success in part due...
In this article, we will explain what culture is and why it such a complex concept. Culture encompasses many aspects of human life, as shared beliefs, values, customs, behaviors. Cultures often vary by region or location, they can change evolve over time. Socialization, the process learning to adapt one’s thinking, behavior, skills, attitudes fit into society, an important way passed on between people develop from childhood adulthood. Finally, discuss psychological termed acculturation,...