A5088923264- Chemical Synthesis and Analysis
- Cannabis and Cannabinoid Research
- Synthesis and Catalytic Reactions
- Synthetic Organic Chemistry Methods
- Peptidase Inhibition and Analysis
- Cholesterol and Lipid Metabolism
- Biochemical Analysis and Sensing Techniques
- Monoclonal and Polyclonal Antibodies Research
- Marine Toxins and Detection Methods
- Ubiquitin and proteasome pathways
- Advanced biosensing and bioanalysis techniques
- HER2/EGFR in Cancer Research
- Edible Oils Quality and Analysis
- Diet, Metabolism, and Disease
- Atherosclerosis and Cardiovascular Diseases
- Click Chemistry and Applications
- Catalytic C–H Functionalization Methods
- Advanced Synthetic Organic Chemistry
- Computational Drug Discovery Methods
- Cyclopropane Reaction Mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Drug Solubulity and Delivery Systems
Universidad de Málaga
2022-2025
Due to its natural origin and numerous beneficial properties, cannabidiol (CBD), one of the major phytocannabinoids Cannabis sativa L., has attracted attention many research groups in recent years. In this work, we prepared 4-vinylpyridine (4VP) CBD co-polymeric nanoparticles (solid@poly-4VP-co-CBD) using N,N'-methylenbisacrylamide (BIS) as cross-linker, which is covalently incorporated into polymeric structure. We evaluated particle morphology by Transmission Electron Microscopy (TEM),...
Hydroxytyrosol (HT) is a bioactive phenolic compound naturally present in olives and extra virgin olive oil (EVOO) which described as an antioxidant, antitumoral antiangiogenic molecule. Previous studies of semi-synthetic HT-derivatives presented the hydroxytyrosyl alkyl ether HT-C6 one most potent derivatives studied context anti-platelet assays, but its direct effect on inflammation was not reported. In this work, we use RT-qPCR measure gene expression, protein analysis by Western-blot...
Lung cancer is the most commonly diagnosed and one that causes deaths worldwide, so there a need for therapies improve survival rates. Products derived from marine organisms are source of novel potent antitumor compounds, but they present great obstacle their obtaining natural environment problems associated with synthesis biological effects chemical analogues. In this work, Bengamide analogue (Bengamide II) was chemically synthesized in vitro vivo studies were performed to determine its...
Abstract Cannabidiol (CBD) is garnering increasing interest due to its significant biological activity. This natural compound one of the major cannabinoids in Cannabis sativa L. In this work, we describe encapsulation CBD solid and hollow pH‐sensitive poly (4‐vinylpyridine) (solid@ p 4VP hollow@ 4VP) nanoparticles, temperature‐sensitive ( N ‐isopropylacrylamide) NIPAM NIPAM) nanoparticles for transport release a controlled manner. The loading into these smart polymeric systems was effective...
A simple and fully operational process of [2,3]-sigmatropic rearrangement that does not involve the use carbenes or associated hazardous sensitive reagents in an open flask reaction at room temperature.
Due to its natural origin and numerous beneficial properties, cannabidiol (CBD), one of the major phytocannabinoids Cannabis sativa L. has attracted attention in recent years. In this work, solid hollow pH-sensitive poly(4-vinylpyridine) (solid@p4VP hollow@p4VP) nanoparticles, temperature-sensitive poly(N-isopropylacrylamide) (solid@pNIPAM hollow@pNIPAM) nanoparticles have been prepared used transport release CBD a controlled manner. Hollow were from oxidation gold core center nanoparticle....
A mathematical concept, n-tuples are originally applied to medicinal chemistry, especially with the creation of scaffold diversity inspired by hybridisation different commercial drugs cytarabine, a synthetic arabinonucleoside derived from two marine natural products, spongouridine and spongothymidine. The new methodology explores virtual chemical-factorial combination (immunosuppressant, antibiotic, antiemetic, anti-inflammatory, anticancer) anticancer drug cytarabine. Real chemical...