A5004305903- Inflammatory Biomarkers in Disease Prognosis
- Piperaceae Chemical and Biological Studies
- Ion Channels and Receptors
- Cancer, Lipids, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Chemical Synthesis and Analysis
- Computational Drug Discovery Methods
- Advanced Chemical Sensor Technologies
- Ubiquitin and proteasome pathways
- Synthesis and Biological Activity
- Phytochemistry and Bioactivity Studies
- Ethnobotanical and Medicinal Plants Studies
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Drug-Induced Hepatotoxicity and Protection
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Immune cells in cancer
- Marine Sponges and Natural Products
- Microbial Metabolism and Applications
- Ferroptosis and cancer prognosis
- Microbial Natural Products and Biosynthesis
Universidad de Granada
2023-2024
Instituto de Investigación Biosanitaria de Granada
2023-2024
Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research
2019-2022
Estación Experimental del Zaidín
2021
Abstract Disseminated disease is present in ≈50% of colorectal cancer patients upon diagnosis, being responsible for most deaths. Addition biological drugs, as Bevacizumab, to chemotherapy, has increased progression free survival and overall metastatic (mCRC) patients. However, these benefits have been only reported a small proportion To date, there are not biomarkers that could explain the heterogeneity this would help treatment selection. Recent findings demonstrated microRNAs (miRNAs)...
Background: Platelets are active players in tumorigenesis, although the exact interactive mechanisms and their direct impact on tumor cells remain largely unknown.Methods: Bidirectional transference of lipids, proteins RNA between platelets its cell behavior process analyzed this work.Phenotypic, genetic functional modifications induced by were both lines circulating (CTCs).Results: Data from these assays showed that transferred structural components to with higher efficiency than (p =...
Plant species are precursors of a wide variety secondary metabolites that, besides being useful for themselves, can also be used by humans their consumption and economic benefit. Pepper (Capsicum annuum L.) fruit is not only common food spice source, it stands out containing high amounts antioxidants (such as vitamins C A), polyphenols capsaicinoids. Particular attention has been paid to capsaicin, whose anti-inflammatory, antiproliferative analgesic activities have reported in the...
Plant species are precursors of a wide variety secondary metabolites that, besides having useful activity for themselves, can also be used by humans their consumption and economic benefit. Pepper (Capsicum annuum L.) fruit is not only common food spice source, but it stands out containing high amounts antioxidants (such as vitamins C A), polyphenols capsaicinoids. Particular attention has been paid to capsaicin, whose anti-inflammatory, antiproliferative analgesic activities, have proven....
Lung cancer is the most commonly diagnosed and one that causes deaths worldwide, so there a need for therapies improve survival rates. Products derived from marine organisms are source of novel potent antitumor compounds, but they present great obstacle their obtaining natural environment problems associated with synthesis biological effects chemical analogues. In this work, Bengamide analogue (Bengamide II) was chemically synthesized in vitro vivo studies were performed to determine its...
Abstract Plants provide a wide array of compounds that can be explored for potential anticancer properties. Siphonochilone, furanoterpene represents one the main components African plant Siphonochilus aethiopicus , shows numerous health benefits. However, to date, its antiproliferative properties have not been tested. The aim this study was analyze cytotoxic effects siphonochilone on panel cancer cell lines and underlying mechanism action. Our results demonstrated exhibited significant...
Abstract BackgroundPlatelets are active players in tumorigenesis, although the exact interactive mechanisms and their direct impact on tumor cells remain largely unknown. MethodsBidirectional transference of lipids, proteins RNA between platelets its cell behavior process analyzed this work. Phenotypic, genetic functional modifications induced by were both lines circulating (CTCs). ResultsBesides cross-talk cells, we demonstrated an efficient exchange RNA. Remarkably, observed that...