A5101912183- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Optical Imaging and Spectroscopy Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Non-Invasive Vital Sign Monitoring
- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- Ion channel regulation and function
- Sleep and Wakefulness Research
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Genetic Neurodegenerative Diseases
- Neuroscience and Music Perception
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Music Therapy and Health
University of Chicago
2020
OSF HealthCare
2020
Johns Hopkins University
2016-2019
University of Illinois Chicago
2015-2019
University of Illinois Urbana-Champaign
2019
Illinois College
2019
Johns Hopkins Medicine
2017-2019
Despite a growing number of ion channel genes implicated in hereditary ataxia, it remains unclear how mutations lead to loss-of-function or death cerebellar neurons. Mutations the gene KCNMA1, encoding α-subunit BK have emerged as responsible for variety neurological phenotypes. We describe mutation (BKG354S) child with congenital and progressive ataxia cognitive impairment. The selectivity filter dramatically reduced single-channel conductance selectivity. BKG354S trafficked normally...
Clinical and preclinical studies indicate that early postnatal exposure to anesthetics can lead lasting deficits in learning other cognitive processes. The mechanism underlying this phenomenon has not been clarified there is no treatment currently available. Recent evidence suggests might cause persistent function by disrupting key events brain development. hippocampus, a region critical for memory, contains large number of neurons develop the period, which are thus vulnerable perturbation...
Human epidemiologic studies and laboratory investigations in animal models suggest that exposure to general anesthetic agents (GAs) have harmful effects on brain development. The mechanism underlying this putative iatrogenic condition is not clear there are currently no accepted strategies for prophylaxis or treatment. Recent evidence suggests anesthetics might cause persistent deficits synaptogenesis by disrupting key events neurodevelopment. Using an vitro model consisting of dissociated...
With conventional magnetic resonance imaging (MRI), 20-30% of patients with temporal lobe epilepsy (TLE) have negative pathological MRI findings. Further investigations the role spectroscopy (MRS) in pre-surgical evaluation MRI-negative TLE are important to avoid intracranial EEG recording and better understand mechanism epileptogenic process. This study aimed compare measurements N-acetylaspartate (NAA), creatine (Cr), choline (Cho) hippocampi normal subjects.Twenty 10 age-matched healthy...
Human epidemiologic studies and laboratory investigations in animal models suggest that exposure to general anesthetic agents (GAs) have harmful effects on brain development. The mechanism underlying this putative iatrogenic condition is not clear there are currently no accepted strategies for prophylaxis or treatment. Recent evidence suggests anesthetics might cause persistent deficits synaptogenesis by disrupting key events neurodevelopment. Using an vitro model consisting of dissociated...
Abstract Background Music has been associated with therapeutic properties for thousands of years across a vast number diverse regions and cultures. This study expands upon our current understanding music’s influence on human neurophysiology by investigating the effects various music genres cerebral cortex activity using electroencephalography (EEG). Methods A randomized, controlled design was used. EEG data were recorded from 23 healthy adults, ages 19–28, while listening to sequence...
Early postnatal exposure to general anesthetic agents causes a lasting impairment in learning and memory animal models. One hypothesis explain this finding is that during critical points neural development disrupts the formation of brain circuitry. Here, we explore effects sevoflurane on neuronal growth cone, specialization at growing end axons dendrites responsible for targeted underlies connectivity between neurons.Dissociated cultures were prepared from embryonic mouse neocortex....
OBJECTIVE: To study the progressive disruption of default-mode network (DMN) connectivity and meaningful consciousness in patients with Hepatic Encephalopathy its underlying pathophysiology using resting state fMRI. BACKGROUND: Functional MRI imaging has become a crucial clinical tool for studying function human brain non-invasively by doing so various networks have been identified. encephalopathy (HE) can present acutely wide variety manifestations including reversible coma although...