A5018999206- Oral microbiology and periodontitis research
- Antimicrobial Peptides and Activities
- Rheumatoid Arthritis Research and Therapies
- Problem and Project Based Learning
- Oral Health Pathology and Treatment
- Dental Research and COVID-19
- Systemic Lupus Erythematosus Research
- Salivary Gland Disorders and Functions
- Biomedical and Engineering Education
- Immune Response and Inflammation
- HIV/AIDS oral health manifestations
- Immune Cell Function and Interaction
- Dental Health and Care Utilization
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Dental Erosion and Treatment
- Mast cells and histamine
- Medical Imaging and Pathology Studies
- Sarcoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Bacterial biofilms and quorum sensing
- Urbanization and City Planning
- Immunodeficiency and Autoimmune Disorders
- Cytokine Signaling Pathways and Interactions
University of Glasgow
1984-2024
Newcastle University
1990
Objectives The composition of dental plaque has been well defined, whereas currently there is limited understanding the denture and how it directly influences related stomatitis (DS). aims this study were to compare microbiomes wearers, understand implications these towards inter-kingdom host-pathogen interactions within oral cavity. Methods Swab samples obtained from 123 participants wearing either a complete or partial denture; bacterial each sample was determined using bar-coded illumina...
Cytokines mediate the balance between protective and destructive immunity in periodontitis. We sought to investigate role of IL-33 The expression gingival tissue from healthy controls ( n = 10) patients with chronic periodontitis 17) was investigated. Based on a murine model periodontal disease, function determined first by administration exogenous second inhibition signaling using mice deficient receptor ST2. Alveolar bone level, serum antibody, lymphocyte responses were assessed model....
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks provide an update interventional mechanistic investigations, including a brief summary European Research programs investigating link between Recent clinical studies are described that evaluate treatment one disease impacts other, as in humans animal models have sought identify potential mechanisms linking two diseases.
Periodontitis (PD) results from complex interactions between a dysbiotic oral microbiota and dysregulated host immune response. The inflammatory infiltrate in the gingiva of PD patients includes an abundance B cells, implicating these cells immunopathology. We sought to investigate role using murine model. Wild-type or B-cell-deficient (μMT) mice were orally infected with Porphyromonas gingivalis. One six weeks following infection, lymphocyte populations cervical draining lymph nodes (dLN)...
Background and Objective Different bacteria differentially stimulate epithelial cells. Biofilm composition viability are likely to influence the response. In vitro model systems commonly used investigate periodontitis‐associated their interactions with host; therefore, understanding factors that biofilm–cell is essential. The present study aimed develop in monospecies multispecies biofilms response these biofilms. Material Methods Bacterial were cultured then either live or methanol‐fixed...
Secretion of antimicrobial proteins (AMPs) and salivary antibodies can modify biofilm formation at host body surfaces. In adolescents, associations have been reported between dental caries AMPs. AMPs demonstrate direct effects high concentrations, lower more physiological concentrations they mediate changes in cell defenses, which may alter the local environment indirectly shape formation. The expression preschool children, an age when oral bacteria are known to change, has not investigated....
Periodontitis is a chronic inflammatory and bone-destructive disease. Development of periodontitis associated with dysbiosis the microbial community, which may be caused by periodontal bacteria, such as Porphyromonas gingivalis. Mast cells are sentinels at mucosal surfaces potent source mediators, including tumor necrosis factors (TNF), although their role in pathogenesis remains to elucidated. This study sought determine contribution mast local bone destruction following oral infection P....
In rheumatoid arthritis, the emergence of anti-citrullinated autoimmunity is associated with HLA-antigen-T cell receptor complexes. The precise mechanisms underpinning this breach tolerance are not well understood. Porphyromonas gingivalis expresses an enzyme capable non-endogenous C-terminal citrullination potential to generate citrullinated autoantigens. Here we document how ovalbumin peptide323-339 alters interaction between antigen-presenting cells and OTII T induce functional changes in...
Abstract Understanding the triad of host response, microbiome and disease status is potentially informative for prediction, prevention, early intervention treatment. Using longitudinal assessment saliva status, we demonstrated that partial least squares modelling microbial, immunological clinical measures, grouped children according to future dental status. Saliva was collected health assessed in 33 aged 4 years, again 1-year later. The composition salivary defence peptides were quantified....
Innate lymphoid cells (ILCs) are a population of lymphocytes that act as the first line immunologic defense at mucosal surfaces. The ILC family in skin, lungs, and gastrointestinal tissues has been investigated, there reports individual subsets ILCs oral tissues. We sought to investigate whole (group 1, 2, 3 subsets) murine gingivae lymph nodes draining cavity. show made up greater proportion CD45+ lymphocyte (0.356% ± 0.039%) compared with (0.158% 0.005%). Cytokine profiling populations...
Despite existing preventive and therapeutic measures, caries remains a ubiquitous infectious disease. Vaccine studies suggest that an adaptive immune response, culminating in effective antibody production, may reduce individual’s susceptibility to caries. However, the efficacy of response elicited by mutans streptococci oral cavity controversial. A greater understanding early stages cariogenic bacteria potentially assist targeting design. We therefore sought characterize dendritic cell (DC)...
The University of Glasgow Bachelor Dental Surgery (BDS) degree programme is a practical clinical professionally regulated discipline. Given the mode transmission SARS Cov-2 dental profession and associated programmes study have been significantly impacted by COVID-19 pandemic, necessitating rapid pivot to online blended learning. This case shows how work early adopters technology enhanced learning teaching (TELT) at school, timely staff-student partnership helped lay foundations for this in...
There are well established epidemiological links between rheumatoid arthritis and periodontitis. Recent data have started to shed light on the mechanisms that might underlie relationship these two complex diseases. Unravelling roles of distinct pathways involved in has potential yield novel preventative therapeutic strategies for both Perhaps most intriguingly, this represents an area where understanding biology oral cavity reveal fundamental advances immune regulation relationships host...
The University of Glasgow Bachelor Dental Surgery (BDS) degree programme is a practical clinical professionally regulated discipline. Given the mode transmission SARS Cov-2 dental profession and associated programmes study have been significantly impacted by COVID-19 pandemic, necessitating rapid pivot to online blended learning. This case shows how work early adopters technology enhanced learning teaching (TELT) at school, timely staff-student partnership helped lay foundations for this in...