A5068946239- dental development and anomalies
- Oral and Maxillofacial Pathology
- Cleft Lip and Palate Research
- Cancer-related gene regulation
- Dental Trauma and Treatments
- Drug-Induced Adverse Reactions
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Advanced biosensing and bioanalysis techniques
- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
Banaras Hindu University
2014-2022
Center for Cancer Research
2022
Cancer Genetics (United States)
2022
The use of cationic polymer based gene delivery vectors has several limitations such as low transfection efficiency, high toxicity, and inactivation by serum. present work provides an inorganic nanocarrier for efficient a method preparing the same through facile coprecipitation technique. vehicle showed loading capacity DNA can release loaded in controlled pH-responsive manner. developed offers remarkable protection against DNase I also thermal damage. This demonstrated cellular uptake...
Congenital tooth agenesis in human is characterized by failure of development during organogenesis. 300 genes mouse and 30 so far have been known to regulate development. However, candidature only 5 viz. PAX9, MSX1, AXIN2, WNT10A EDA experimentally established for congenitally missing teeth like hypodontia oligodontia. In this study an Indian family with multiple congenital was identified. Pattern inheritance apparently autosomal dominant type a rare possibility be X-linked. Whole genome...
IntroductionThe nucleoside analogue reverse-transcriptase inhibitor Abacavir has potent antiviral activity against HIV; however, 5–8% patients develop hypersensitivity reactions within six weeks of treatment. The presence the HLA-B*57:01 allele is strongly associated with risk Abacavir-associated reaction (ABC-HSR). Prevalence varies in different populations. This observational study was performed to determine prevalence population Eastern India which included both HIV-positive and...
Background Congenital tooth agenesis (CTA), a type of craniofacial disorders affects approximately 20% (including 3 molar or Wisdom teeth) and 2-10% (excluding molar) the world population. Five major candidate genes known to be associated with syndromic non-syndromic CTA, these are PAX9, MSX1, AXIN2, EDA WNT10A. The present investigation was undertaken identify characterize disease causing genetic variant by conventional genotyping whole genome sequencing in familial
Abstract Congenital tooth agenesis (CTA) is one of the most common craniofacial anomalies. Its frequency varies among different population depending upon genetic heterogeneity. CTA could be familial or sporadic and syndromic non-syndromic. Five major genes are found to associated with non-syndromic namely, PAX9, MSX1, EDA1, AXIN2 WNT10A . In this study, an India family was investigated a novel c.336C>G variation identified in exon 3 PAX9 , leading substitution evolutionary conserved Cys...