A5032964023- Cyclopropane Reaction Mechanisms
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Asymmetric Hydrogenation and Catalysis
- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Fluorine in Organic Chemistry
- Catalytic Alkyne Reactions
- CO2 Reduction Techniques and Catalysts
- Catalytic Cross-Coupling Reactions
- Synthesis and Catalytic Reactions
- Axial and Atropisomeric Chirality Synthesis
- Metalloenzymes and iron-sulfur proteins
- Chemical Reactions and Isotopes
- Chemical Synthesis and Analysis
- Enzyme Catalysis and Immobilization
- Asymmetric Synthesis and Catalysis
Institut Català d'Investigació Química
2016-2025
Robert Bosch (Germany)
2021
École Polytechnique Fédérale de Lausanne
2020-2021
Micron (United States)
2021
Micron Biomedical (United States)
2021
Harm Reduction Services
2021
New York University
2019
Institute for Basic Science
2019
Korea Advanced Institute of Science and Technology
2019
KTH Royal Institute of Technology
2019
Direct addition of water to alkenes generate important chiral alcohols as key motif in a variety natural products still remains challenge organic chemistry. Here, we report the first enantioselective artificial metallo-hydratase, based on transcription factor LmrR, which catalyses conjugate β-hydroxy ketones with enantioselectivities up 84% ee. A mutagenesis study revealed that an aspartic acid and phenylalanine located active site play role achieving efficient catalysis high enantioselectivities.
Abstract The first stereoconvergent cyclopropanation reaction by means of photoredox catalysis using diiodomethane as the methylene source is described. This transformation exhibits broad functional group tolerance and it characterized an excellent stereocontrol en route to trans ‐cyclopropanes regardless whether E‐ or Z ‐styrene substrates were utilized.
Catalytic enantioselective C–H functionalization has recently become a tool for the creation of stereogenic centers. The steep increase in molecular complexity multicomponent reactions matches very well with asymmetric functionalizations, but realization such processes remains large challenge. We describe diastereoselective and highly three-component catalyzed by an earth-abundant Co(III) complex equipped chiral cyclopentadienyl ligand (Cpx). transformation provides rapid access to...
Abstract The creation of new chiral ligands capable providing high stereocontrol in metal‐catalyzed reactions is crucial modern organic synthesis. production bioactive molecules as single enantiomers increasingly required, and asymmetric catalysis with metal complexes constitutes one the most efficient synthetic strategies to access optically active compounds. Herein we offer a historical overview on development derivatives ubiquitous cyclopentadienyl ligand (Cp X ), detail their successful...
Herein, we present a novel class of diazo compounds as atomic carbon reagents substituted with two orthogonal redox-active leaving groups that were exploited in the late-stage construction chiral centers aryl C–H bonds from aromatic feedstocks and drug molecules. Key to strategy was use photoredox catalysis enable an initial diazomethylation reaction able generate diazomethyl-substituted esters. Subsequent readily available starting materials proceeded using broad range well-known ester...
A visible-light-enabled, operationally simple cyclopropanation reaction of styrenes with excellent functional group tolerance and chemoselectivity <italic>via</italic> carbenoid-like radicals.
We describe the recent emergence of a new approach for synthesis cyclopropane rings by means photoredox catalysis. This methodology relies on photocatalytic generation radical carbenoids or carbenoid-like radicals as cyclopropanating species, and is characterized excellent functional group tolerance, chemoselectivity ability to form cyclopropanes with control from E/Z alkene mixtures. The mild reaction conditions employment user-friendly reagents are highly attractive features that may lead...
Abstract The first stereoconvergent cyclopropanation reaction by means of photoredox catalysis using diiodomethane as the methylene source is described. This transformation exhibits broad functional group tolerance and it characterized an excellent stereocontrol en route to trans ‐cyclopropanes regardless whether E‐ or Z ‐styrene substrates were utilized.
Abstract The first artificial metallo‐hydratase, which catalyses the conjugate addition of water to give chiral β‐hydroxy ketones with high enantioselectivities is described.
Seit römischer Zeit ist Tarragona eine Heimstätte für Entdeckungen. In dieser guten Tradition präsentieren M. G. Suero et al. in der Zuschrift auf S. 1632 ff. ein neues Reaktivitätskonzept. Beim Studium einer Photoredoxreaktion die stereokonvergente Cyclopropanierung von Alkenen fanden sie als Schlüsselintermediat Iodmethylradikal, bezeichnet radikalisches Carbenoid. Obwohl es Radikal ist, seine Reaktivität ähnlich zu Singulett- und komplementär Triplett-Carbenen, was neue Möglichkeiten...