A5058512664- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Smoking Behavior and Cessation
- Metabolomics and Mass Spectrometry Studies
- Mass Spectrometry Techniques and Applications
- Phytochemicals and Antioxidant Activities
- DNA and Nucleic Acid Chemistry
- Fermentation and Sensory Analysis
- Pharmaceutical and Antibiotic Environmental Impacts
- Protein Structure and Dynamics
- Advanced biosensing and bioanalysis techniques
- Antibiotic Resistance in Bacteria
- Synthetic Organic Chemistry Methods
- Antibiotics Pharmacokinetics and Efficacy
- Biochemical and Molecular Research
- Consumer Packaging Perceptions and Trends
- RNA and protein synthesis mechanisms
- Venomous Animal Envenomation and Studies
- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Neuroscience of respiration and sleep
- Cannabis and Cannabinoid Research
- Bioactive Compounds and Antitumor Agents
- Indoor Air Quality and Microbial Exposure
- Advanced Chemical Sensor Technologies
University of Wollongong
2014-2024
Illawarra Health and Medical Research Institute
2018-2023
Sustainable Horizons Institute
2019
Gem Pharmaceuticals (United States)
2009
Georgetown University
2009
Significance Using a translational photosynthesis approach, we successfully increased CO 2 -assimilation in leaf chloroplasts of the model plant tobacco. Phylogenetic analysis revealed parallel evolutionary linkages between large (L-) subunit -fixing enzyme Rubisco and its molecular chaperone accumulation factor 1 (RAF1). We experimentally tested exploited this correlation using plastome transformation, producing plants that demonstrated role RAF1 L-subunit assembly resolve quaternary...
This project utilizes visual and critical thinking approaches to develop a higher-education synergistic prelab training program for large second-year undergraduate analytical chemistry class, directing more of the cognitive learning phase. enabled students engage in prior engaging action laboratory, motivating arrive at classes prepared material rather than mechanics (physical processes) practical exercises. reduced likelihood overload beginning class. Video demonstrations were developed...
A range of flavoring molecules are used in electronic cigarette liquids (e-liquids), some which have been shown to form cyclic acetal adducts with e-liquid solvent components propylene glycol (PG) and vegetable glycerine (VG). The objective this study was identify the products. Common (N = 36) from a chemical class groups were exposed PG, VG, or methanol analyzed by GC-MS over time frame 4 weeks possible reaction Adduct formation observed, 14 reacting methanol, 10 VG. Furfural PG VG acetals,...
Abstract Introduction E-cigarettes are becoming increasingly popular in Australia, especially amongst the younger population. The synthetic cooling molecules WS-3 and WS-23 have been identified e-cigarette products from United States Europe. extent of inclusion these coolants Australian e-liquids is unknown, particularly newer disposable e-cigarettes. Aims Methods were purchased within Australia anonymously donated by users. Nicotine, WS-3, WS-23, menthol quantified using gas...
Determination of collisional cross sections (CCS) by travelling wave ion mobility mass spectrometry (TWIM-MS) requires calibration against standards for which the CCS has been measured previously drift tube (DTIM-MS). The different extents activation in TWIM-MS and DTIM-MS can give rise to discrepancies calibrants across two platforms. Furthermore, conditions required ionize transmit large, folded proteins assemblies may variably affect structure analytes. Stable hetero-oligomeric...
Colistin and carbapenems, vital last-resort antibiotics against severe bacterial infections unresponsive to common drugs, pose a significant threat when resistance develops, potentially leading total antibiotic ineffectiveness. The estimation quantification of colistin carbapenems in environmental samples is notably challenging due expected low concentrations, complex structures, stability issues, potential interference from other substances. Despite known side-effects, the biological impact...
In Australia, electronic cigarette (e-cigarette) use has nearly tripled since 2019, despite legal restrictions.1 These vaping products generally contain the carrier fluids propylene glycol and glycerine, flavouring chemicals, cooling agents, nicotine.2 Most users purchase their outside intended sources,3, 4 in what federal government describes as a "black market".5 At time of study reported this article, prescription was required for purchasing nicotine-containing e-cigarette Australia.6 To...
The folding and assembly of Rubisco large small subunits into L8 S8 holoenzyme in chloroplasts involves many auxiliary factors, including the chaperone BSD2. Here we identify apparent intermediary Rubisco-BSD2 complexes model C3 plant tobacco. We show BSD2 content decrease tandem with leaf age approximately half young leaves (~70 nmol protomer.m2 ) stably integrated putative that account for <0.2% pool. RNAi-silencing production transplastomic tobacco producing bacterial L2 had no effect on...
Carbapenems are last-resort antibiotics used to treat bacterial infections unsuccessfully treated by most common categories of in humans. Most their dosage is secreted unchanged as waste, thereby making its way into the urban water system. There two major knowledge gaps addressed this study gain a better understanding effects residual concentrations on environment and environmental microbiome: development UHPLC-MS/MS method detection quantification from raw domestic wastewater via direct...
3581 Background: GMX1777 is a pro-drug which converts to GMX1778, potent and specific small molecule inhibitor of NAMPRT, the rate-limiting enzyme in NAD+ synthesis. NAMPRT activity increased tumor cells dependent on glycolytic pathway. The aims this first-in-man study were define dose administered by 24-hr infusion with acceptable safety for phase II studies, determine pharmacokinetic (PK) parameters both GMX1778. Methods: was at ascending doses as 24 hour IV q21 days successive cohorts...
Synthetic cannabinoid receptor agonists (SCRAs) are the most diverse class of new psychoactive substances worldwide, with approximately 300 unique SCRAs identified to date. While use this drug is not particularly prevalent, associated several deaths every year due their severe toxicity.
We have prepared six new nickel Schiff base complexes via reactions of substituted benzophenones with different diamines in the presence nickel(ii). These were then reacted 1-(2-choroethyl)piperidine to afford a further novel nickel(ii) bearing pendant ethylpiperidine groups. The moieties had greater solubility water, and therefore suitable for use DNA binding experiments. ESI mass spectra solutions containing 4 parallel, tetramolecular quadruplex Q4, contained ions attributable formation...
Introduction: Adolescent usage of electronic cigarettes has increased globally. Inconsistent, or absent, labelling nicotine and other ingredients requires chemical analysis to accurately determine the composition these products. Methods: Electronic confiscated from public private high school students (N=598) were provided for three regions in New South Wales, Australia. The products examined brand, model flavour a subset further analysed (n=410) quantifying nicotine, synthetic cooling...
Background: The sale of nicotine-containing electronic cigarettes (e-cigarettes) is prescription only in Australia, regulated under the TGO110. Australian e-cigarette users, however, are purchasing products outside intended pathways. Methods: labelling packaging (N=388 boxes) and chemical composition disposable e-cigarettes pods (N=428) were analysed for adherence to current regulations. These samples obtained from over-the-counter retailers NSW. Results: Following announcement model...
Background: The sale of nicotine-containing electronic cigarettes (e-cigarettes) is prescription only in Australia, regulated under the TGO110. Australian e-cigarette users, however, are purchasing products outside intended pathways. Methods: labelling packaging (N=388 boxes) and chemical composition disposable e-cigarettes pods (N=428) were analysed for adherence to current regulations. These samples obtained from over-the-counter retailers NSW. Results: Following announcement model...