A5101947587- Protein Interaction Studies and Fluorescence Analysis
- Click Chemistry and Applications
- Pineapple and bromelain studies
- Lanthanide and Transition Metal Complexes
- Photochemistry and Electron Transfer Studies
- Nanoplatforms for cancer theranostics
- Zebrafish Biomedical Research Applications
- Cancer Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Cancer Genomics and Diagnostics
- Microtubule and mitosis dynamics
- Pharmacological Effects of Natural Compounds
- Medicinal Plants and Neuroprotection
- Glycosylation and Glycoproteins Research
- Metal complexes synthesis and properties
- Remote Sensing in Agriculture
- Enzyme Structure and Function
- Phytochemical compounds biological activities
- Biochemical and Structural Characterization
- Pluripotent Stem Cells Research
- Remote-Sensing Image Classification
- Molecular Sensors and Ion Detection
- Marine and coastal ecosystems
- Inorganic and Organometallic Chemistry
- Protein Structure and Dynamics
Presidency University
2017-2024
Indian Space Research Organisation
2023
Presidency University
2022
The investigation of the binding 4-AC to biomolecular systems using photophysical techniques and molecular docking studies.
A novel triazole-coumarin compound 2-oxo-N-((1-(6-oxo-6-(p-tolylamino)hexyl)-1H-1,2,3-triazol-4-yl)methyl)-2H-chromene-3-carboxamide (compound 6) and quinoline N-((1-(6-oxo-6-(p-tolylamino)hexyl)-1H-1,2,3-triazol-4-yl)methyl)quinoline-6-carboxamide 9) are designed synthesized using Cu(I)-catalyzed cycloaddition of alkyne azide reaction. The binding interaction coumarin compounds with bovine serum albumin human has been explored different photophysical studies. To determine the feasible sites...
The photophysics of 4-azidocoumarin (4-AC), a novel fluorescent coumarin derivative, is well established by the investigation alteration microheterogeneous environment comprising two types systems: supramolecular systems, cyclodextrins (CDs), and biomolecular serum albumins (SAs). enhanced emission ligand with organized assemblies like α-CD, β-CD, γ-CD steady-state time-resolved fluorescence anisotropy at 298 K compared those bovine albumin (BSA) human (HSA). remarkable enhancement 4-AC...
De novo drug design tends to discover a new chemical entity that sits at the active site of target protein, receptor or enzyme. It starts by exploiting an existing moiety and we keep modifying it adding subtracting fragments step-by-step, so maybe when particular group is added increases electrostatic interaction improves hydrophobic produces good hydrogen bond donor reduces steric repulsions van der Walls repulsion. Assembling novel moieties from pieces are positioned optimally in...
Study of interaction small molecules with serum albumins is very much essential in the perspective pharmaceutical and food chemistry. Triazoles are nitrogen containing heterocyclic organic compounds can show binding amino acid residues proteins via mainly H-bonding using atoms. Here we have synthesized a triazole based compound tert-butyl(6-oxo-6-(((1-(2-oxo-2H-chromen-4-yl)-1H-1,2,3-triazol-4-yl) methyl)amino) hexyl)carbamate (SAM-1) CuAAC reaction investigated its (BSA, HSA) Bromelain...
Zinc is one of the most essential trace elements in periodic table which directly involved several enzymatic and biological activities human body. Research has mainly focused catalytic applications complex; however fluorescence property its co-relation with 3d 4f metal ions are hitherto unexplored. In last decades active Schiff base (H 2 L) was synthesised using o-vanillin ethylene diamine room temperature stirring. Herein, complexes Zn(II) Zn(II)-Tb(III) were characterized. Photo physical...
Data from ocean color monitoring sensors at different spectral channels are available for remote sensing of radiation as seen in the given windows, which is used deriving information on various atmospheric parameters. However, recent studies have demonstrated potential hyperspectral (HS) data over multispectral (MSOC) accurately estimating phytoplankton concentration and coastal dynamics. We propose system shape factor (SSSF)-based approach to recover embedded HS top-of-atmosphere (TOA)...