A5036074467- Chemical Synthesis and Reactions
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Protein Interaction Studies and Fluorescence Analysis
- Synthetic Organic Chemistry Methods
- Synthesis and Catalytic Reactions
- Multicomponent Synthesis of Heterocycles
- Synthesis of heterocyclic compounds
- Oxidative Organic Chemistry Reactions
- Asymmetric Hydrogenation and Catalysis
- Click Chemistry and Applications
- Sulfur-Based Synthesis Techniques
- Synthesis and biological activity
- Retinoids in leukemia and cellular processes
- Curcumin's Biomedical Applications
- Marine Sponges and Natural Products
- Lanthanide and Transition Metal Complexes
- Sirtuins and Resveratrol in Medicine
- Advanced Synthetic Organic Chemistry
- Pineapple and bromelain studies
- Bioactive Compounds in Plants
- Phytochemical compounds biological activities
- Medicinal Plants and Neuroprotection
- Phytochemistry and Biological Activities
- Organic and Inorganic Chemical Reactions
Presidency University
2017-2025
Wayne State University
2015-2018
The Barbara Ann Karmanos Cancer Institute
2018
University of Houston
2010-2016
Indian Institute of Chemical Technology
2004-2010
Inha University
2008-2009
We have semi-synthesized a natural product 7-acetylhorminone from crude extract of Premna obtusifolia (Indian headache tree), which is active against colorectal cancer after probation through computational screening methods as it passed the set parameters pharmacokinetics (most important nonblood–brain barrier permeant) and drug likeliness (e.g., Lipinski's, Ghose's, Veber's rule) most other phytoconstituents failed to pass combined with docking EGFR protein highly upregulated in carcinoma...
The investigation of the binding 4-AC to biomolecular systems using photophysical techniques and molecular docking studies.
[reaction: see text] Treatment of the acetyl derivatives Baylis-Hillman adducts 3-hydroxy-2-methylene-alkanoates and 3-hydroxy-2-methylene-alkanenitriles with unactivated alkyl halides in presence Zn saturated aqueous NH(4)Cl solution at room temperature afforded (2E)-2-substituted-alk-2-enoates first case (2Z)-2-substituted-alk-2-enenitriles high (Z)-selectivity second case.
Histone deacetylases (HDAC's) became increasingly important targets for therapy of various diseases, resulting in a pressing need to develop HDAC class- and isoform-selective inhibitors. Class IIa possess only minimal deacetylase activity against acetylated histones, but have several other client proteins as substrates through which they participate epigenetic regulation. Herein, we report the radiosyntheses second generation class IIa–specific radiotracers:...
A novel triazole-coumarin compound 2-oxo-N-((1-(6-oxo-6-(p-tolylamino)hexyl)-1H-1,2,3-triazol-4-yl)methyl)-2H-chromene-3-carboxamide (compound 6) and quinoline N-((1-(6-oxo-6-(p-tolylamino)hexyl)-1H-1,2,3-triazol-4-yl)methyl)quinoline-6-carboxamide 9) are designed synthesized using Cu(I)-catalyzed cycloaddition of alkyne azide reaction. The binding interaction coumarin compounds with bovine serum albumin human has been explored different photophysical studies. To determine the feasible sites...
Abstract A simple and efficient one‐pot method has been developed for the synthesis of α‐aminonitriles by concurrent reaction aldehydes, amines trimethylsilyl cyanide with a catalytic amount NbCl 5 (10 mol%) in CH 3 CN at room temperature. Copyright © 2008 John Wiley & Sons, Ltd.
Resveratrol (1) is a naturally occurring phytoalexin that affects variety of human disease models, including cardio- and neuroprotection, immune regulation, cancer chemoprevention. One the possible mechanisms by which resveratrol these states affecting cellular signaling network involving protein kinase C (PKC). PKC family serine/threonine kinases, whose activity inhibited resveratrol. To develop isotype selective molecules on scaffold, several analogs (2-5) with long aliphatic chain varying...
Treatment of Baylis–Hillman adducts 1 with bromo(dimethyl)sulfonium bromide, Br(Me2)S+Br−, in MeCN was found to stereoselectively afford (Z)- and (E)-allyl bromides 2. The reaction is rapid at room temperature, high-yielding, highly stereoselective.
Abstract Cu(ClO 4 ) 2 ·6H O has been found to be an efficient catalyst for cyanosilylation reaction of aldehydes in THF at room temperature with low catalytic loading (1.0 mol%) short time (mostly within 10 min). Copyright © 2008 John Wiley & Sons, Ltd.
The photophysics of 4-azidocoumarin (4-AC), a novel fluorescent coumarin derivative, is well established by the investigation alteration microheterogeneous environment comprising two types systems: supramolecular systems, cyclodextrins (CDs), and biomolecular serum albumins (SAs). enhanced emission ligand with organized assemblies like α-CD, β-CD, γ-CD steady-state time-resolved fluorescence anisotropy at 298 K compared those bovine albumin (BSA) human (HSA). remarkable enhancement 4-AC...