A5006382528- Multiple Myeloma Research and Treatments
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- Immune cells in cancer
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Hematological disorders and diagnostics
- Peripheral Neuropathies and Disorders
- Protein Degradation and Inhibitors
- Cancer Treatment and Pharmacology
- Chronic Lymphocytic Leukemia Research
- Cancer Genomics and Diagnostics
- Complement system in diseases
- Synthesis and Biological Evaluation
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Fibrosis and Remodeling
- Blood groups and transfusion
- Malaria Research and Control
- Histone Deacetylase Inhibitors Research
- Fibroblast Growth Factor Research
- Lymphoma Diagnosis and Treatment
- Mosquito-borne diseases and control
- Quinazolinone synthesis and applications
Erasmus MC Cancer Institute
2020-2025
Franciscus Vlietland
2024
Sint Franciscus Gasthuis
2024
Multiple Myeloma is driven by clonal plasma cell (cPC)-intrinsic factors and changes in the tumorigenic microenvironment (TME). To investigate if residual polyclonal PCs (pPCs) are disrupted, single-cell (sc) RNAseq sc B-cell receptor analysis were applied a cohort of 46 samples with PC dyscrasias 21 healthy donors (HDs). Out n=234,789 PCs, 64,432 genotypically identified as pPCs frequencies decreasing over different disease stages, from 23.66% monoclonal gammopathy undetermined significance...
Summary The bone marrow permanently harbors high numbers of neutrophils, and a tumor-supportive bias these cells could significantly impact marrow-confined malignancies. In multiple myeloma, the is characterized by inflammatory stromal with potential to influence neutrophils. We investigated myeloma-associated alterations in neutrophils inflammation on neutrophil function. Mature myeloma are activated tumor-supportive, transcribing increased levels IL-1β, cell survival factor BAFF....
Abstract Malignant plasma cells in multiple myeloma patients reside the bone marrow and continuously interact with local immune cells. Progression therapy response are influenced by this environment, highlighting need for a detailed understanding of endogenous responses to malignant Here we used 5TGM1 murine transfer model dissect early We modeled stable progressive disease transferring into C57Bl/6 mice KaLwRij mice, respectively. flow cytometry single‐cell bulk transcriptomic analyses...
SUMMARY Multiple Myeloma (MM) is driven by clonal plasma cell (PC)-intrinsic factors and changes in the tumorigenic microenvironment (TME). To investigate if residual polyclonal PCs (pPCs) are disrupted, single-cell (sc) RNAseq sc B-cell receptor analysis were applied a cohort of 46 samples with PC dyscrasias 18 healthy donors (HDs). Out n= 213,074 CD138 pos PCs, 42,717 genotypically identified as pPCs. Compared to HDs, we detected quantitative qualitative differences pPCs patients showing...
Abstract Multiple myeloma is a disease of malignant plasma cells residing in the bone marrow, where interactions with local immune are thought to contribute pathobiology. However, since multiple diagnosis virtually always preceded by an asymptomatic precursor phase, identifying early alterations marrow micro-environment following occupation remains challenging. Here we used 5TGM1 transfer model murine combination myeloma-permissive KaLwRij mice and myeloma-resistant C57Bl/6 hypothesized that...
Abstract Natural killer (NK) cells mediate the cytotoxic immune response against multiple myeloma and are important effector in therapies through antibody-dependent cellular cytotoxicity. Here, we used single-cell transcriptomics, flow cytometry functional assays to investigate bone marrow NK cell compartment of patients at diagnosis, during treatment after relapse. The is characterized by a reduction conventional that persists throughout treatment. We show 20% newly diagnosed an altered...
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Cancer development and progression are accompanied by alterations in the local microenvironment. In multiple myeloma (MM), interactions between cells their niche considered critical for disease pathobiology. Recently, we showed that MM bone marrow (BM) is characterized inflammatory mesenchymal stromal (iMSCs) transcribe survival factors such as IL6, well myeloid cell modulation CCL2, ANXA1, C3 chemokines bind CXCR1 2. As have been implicated pathophysiology of various malignancies,...