A5001746963- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Aortic Disease and Treatment Approaches
- Multiple Myeloma Research and Treatments
- Chemokine receptors and signaling
- Atrial Fibrillation Management and Outcomes
- Mechanical Circulatory Support Devices
- Tracheal and airway disorders
- Pulmonary Hypertension Research and Treatments
- Cardiac pacing and defibrillation studies
- Immune cells in cancer
- Transplantation: Methods and Outcomes
- Immune Cell Function and Interaction
- Cardiac Arrest and Resuscitation
- Coronary Artery Anomalies
- Infective Endocarditis Diagnosis and Management
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Conditions and Treatments
- Cardiovascular and Diving-Related Complications
- Hematological disorders and diagnostics
- Cardiovascular Issues in Pregnancy
- Vascular anomalies and interventions
- Williams Syndrome Research
Erasmus MC
2016-2025
Erasmus University Rotterdam
2014-2023
Erasmus MC Cancer Institute
2022-2023
Erasmus MC Transplant Institute
2022
Rotterdam University of Applied Sciences
2021
Maastricht University
2016
St. Anna Ziekenhuis
2015
Albert Schweitzer Hospital
2012
The presence of focal fibrillation waves during atrial (AF) can, besides ectopic activity, also be explained by asynchronous activation the endo- and epicardial layer transmurally propagating waves. To provide direct proof endo-epicardial asynchrony, we performed simultaneous high-resolution mapping right wall AF in humans.Intraoperative was (induced) 10 patients with (paroxysmal: n=3; persistent: n=4; longstanding n=3) 4 without a history AF. A clamp made 2 rectangular 8×16 electrode arrays...
Background— Bachmann’s bundle (BB) is considered to be the main route of interatrial conduction and play a role in development atrial fibrillation (AF). The goals this study are characterize presence disorders BB during sinus rhythm their relation with AF. Methods Results— High-resolution epicardial mapping (192 unipolar electrodes, interelectrode distance: 2 mm) was performed 185 patients coronary artery bypass surgery whom 13 had history paroxysmal Continuous monitoring used detect...
Only few studies have reported long-term outcome of the transatrial-transpulmonary approach in current era management tetralogy Fallot (ToF). We investigated 15-year correction via a large cohort successive patients operated 21st century. All infant ToF undergoing between 2000 and 2015 were included (N = 177, 106 male, median follow-up 7.1 (interquartile range 3.0-10.9) years. Data regarding postoperative complications, reinterventions, development atrial ventricular arrhythmia, cardiac...
A new technique is demonstrated for extensive high-resolution intra-operative atrial mapping that will facilitate the localization of fibrillation (AF) sources and identification substrate perpetuating AF. Prior to start extra-corporal circulation, a 8 × 24-electrode array (2-mm inter-electrode distance) placed subsequently on all right left epicardial sites, including Bachmann's bundle, recording unipolar electrograms during sinus rhythm (induced) AF induced by high-frequency pacing at free...
The heterogeneous presentation and progression of atrial fibrillation (AF) implicate the existence different pathophysiological processes. Individualized diagnosis therapy arrhythmogenic substrate underlying AF may be required to improve treatment outcomes. Therefore, this single-center study aims identify areas by intra-operative, high-resolution, multi-site epicardial mapping in 600 patients with heart diseases. Participants are divided into 12 groups according diseases presence prior...
Several techniques for the surgical correction of congenital supravalvular aortic stenosis have been devised. We describe step-by-step approach a slide aortoplasty to correct localized in 3-year-old child with Williams syndrome.
Objective: Allograft conduits are used for reconstruction of the right ventricular outflow tract in congenital heart malformations (biventricular repair) and autograft procedures. A retrospective evaluation allograft right-ventricular-outflow-tract was conducted a cross-sectional quality life study performed. Methods: Between August 1986 March 2009, 509 allografts (435 pulmonary 74 aortic) were implanted 463 pediatric adult patients (308 right-sided 155 procedures). Perioperative follow-up...
Although homografts are often the preferred valve conduits for right ventricular outflow tract (RVOT) reconstruction, data on long-term homograft-related outcomes, durability and impact quality of life (QoL) scarce. The aim this study was therefore to describe homograft function, clinical outcomes QoL after RVOT reconstruction. We performed a single-centre retrospective analysis all consecutive patients who underwent reconstruction with homograft. Multiple subsequent allografts in same were...
Abstract OBJECTIVES Congenital supravalvular aortic stenosis (SVAS) is a rare form of congenital outflow tract obstruction and long-term outcomes are scarcely reported. This study aims to provide an overview after surgical repair for SVAS. METHODS A systematic review published literature was conducted, including observational studies reporting clinical outcome (>2 years) SVAS in children or adults considering >20 patients. Early risks, late event rates time-to-event data were...
Restenosis after aortic arch reconstruction is a known complication in neonates and infants. Homograft the most commonly used patch material for reconstructions our center. Since 2014, tissue-engineered bovine pericardium (CardioCel) has been as an alternative. The aim of study was to determine whether choice affected development restenosis these patients.Data all infants who underwent with use any between 2005 2016 were analyzed. defined by need reintervention, either percutaneous or...
Coarctation of the aorta (CoA) is rarely diagnosed and treated in adults nowadays mostly with percutaneous techniques. The objective this study to report long-term outcomes health-related quality life a unique cohort patients an open surgical repair for their primary adult CoA.Ninety underwent CoA at our tertiary referral centre between 1961 2008 when treatment strategy was exclusively surgical.The median age surgery 24 years (interquartile range 20-36 years), 39 (43%) were asymptomatic...
Background: This study aimed to evaluate the changes in heart transplantation (HTx) waiting list mortality following introduction of Berlin Heart EXCOR (BH EXCOR) Netherlands, as well occurrence adverse events these children. Methods: A retrospective, single-center was conducted including all pediatric patients (≤18 years) awaiting HTx. Patients were grouped two eras based on availability BH our center, era I (1998-2006; not available) and II (2007 July 31, 2018; available). Results: In...
The study objective was to analyze survival and incidence of Fontan completion patients with single-ventricle concomitant unbalanced atrioventricular septal defect.Data from 4 Dutch 3 Belgian institutional databases were retrospectively collected. A total 151 defect selected; 36 underwent an valve procedure (valve surgery group). End points survival, completion, freedom reoperation.Median follow-up 13.4 years. Cumulative 71.2%, 70%, 68.5% at 10, 15, 20 years, respectively. An not a risk...
Background Major aortopulmonary collateral arteries (MAPCAs), as seen in patients with pulmonary atresia, are that supply blood from the aorta to lungs and often require surgical intervention. To achieve complete repair least number of interventions, optimal imaging arterial anatomy MAPCAs is critical. 3D virtual reality (3D-VR) a promising upcoming new technology could potentially ameliorate current shortcomings. Methods A retrospective, proof-of-concept study was performed all operated...
The number of patients with an arterial switch operation (ASO) for transposition the great arteries (TGA) is steadily growing; limited information available regarding clinical course in current era.