A5023957468- Congenital Heart Disease Studies
- Coronary Artery Anomalies
- Cardiovascular Issues in Pregnancy
- Cardiac Arrhythmias and Treatments
- Aortic Disease and Treatment Approaches
- Atrial Fibrillation Management and Outcomes
- Connective tissue disorders research
- Cardiovascular and Diving-Related Complications
- Venous Thromboembolism Diagnosis and Management
- Blood groups and transfusion
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Blood transfusion and management
- Aortic aneurysm repair treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
Amsterdam University Medical Centers
2021-2024
University of Amsterdam
2016-2023
Netherlands Heart Institute
2021-2023
Leiden University Medical Center
2023
Amsterdam UMC Location University of Amsterdam
2013-2021
Red blood cell (RBC) transfusion has been associated with nosocomial infection in the critically ill patients. However, this association may be confounded by length of stay, as prolonged intensive care unit (ICU stay) increases both risk and transfusion. Also, it is not known whether specific products have differential risks. In prospective multicentre cohort study, bacterial infections (ICU) patients was determined an integrated statistical model, using Cox proportional hazard analysis to...
In the transposition of great arteries (TGA), alterations in hemodynamics and oxygen saturation could result fibrotic remodeling, but histological studies are scarce. We aimed to investigate fibrosis innervation state full spectrum TGA correlate findings clinical literature. Twenty-two human postmortem hearts, including without surgical correction (n = 8), after Mustard/Senning 6), arterial switch operation (ASO, n were studied. newborn uncorrected specimens (1 day-1.5 months), significantly...
The number of patients with an arterial switch operation (ASO) for transposition the great arteries (TGA) is steadily growing; limited information available regarding clinical course in current era.
In patients with transposition of the great arteries and an arterial switch operation (TGA-ASO) right ventricular outflow tract (RVOT) obstruction is a common complication requiring one or more RVOT interventions.
After the arterial switch operation (ASO) for transposition of great arteries (TGA), neo-aortic dilatation and coronary anomalies, especially an interarterial course acute artery take-off angle, are commonly found. Long-term follow-up data after ASO is scarce. Aim this study was to determine prevalence abnormalities, with special emphasis on in adult TGA-ASO patients.
Abstract Objective Aim of this study was (1) to assess the relation between neo-aortic dimensions and coronary angle take-off in adult patients with transposition great arteries (TGA) late after arterial switch operation (ASO) (2) evaluate if temporal increase is associated a decrease take off. Methods In retrospective two-center cohort study, all TGA who underwent ASO had ≥1 CT-angiography (CTA) at age ≥ 16 years old were included. Neo-aortic measured CTA, Figure 1. Results Eighty-one...
Abstract Background The arterial switch operation (ASO) is the current technique of choice for repair transposition great arteries (d-TGA). Its main advantage that left ventricle (LV) sustains systemic circulation, thus diminishing risk late systolic dysfunction as seen in atrial technique. Purpose To study LV performance a large cohort adult patients after ASO and to explore clinical determinants reduced ventricular function (LVSF). Methods EPOCH-ASO an ongoing prospective, multicentre,...
Background: Marfan syndrome (MFS) is a connective tissue disorder with variable aortic root dilatation. Recently, increased transforming growth factor beta (TGF-β) signalling emerged as new potential biochemical pathway leading to disease. The aim of this study was investigate whether TGF-β correlated dilatation, exploring the role prognostic biomarker in MFS. Methods: In correlation between diameters and TGF-β, 86 MFS patients were included. Twenty-five had previously undergone replacement....
Abstract Purpose Clinical practice used to anticoagulated all patients with mild congenital heart defects (CHD) and atrial arrhythmias (AA) because of the presence structural abnormalities. Current guidelines on adult disease indicate that in these patients, as per general, CHA2DS2-VASc score should be followed when deciding upon thromboprophylaxis case AA. To validate this recommendation, we aimed assess incidence thromboembolism CHD according using non-vitamin K oral anticoagulants (NOACs)...