A5087217796- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Mechanical Circulatory Support Devices
- Cardiac pacing and defibrillation studies
- Renal and Vascular Pathologies
- Pulmonary Hypertension Research and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic Disease and Treatment Approaches
- Cardiac Imaging and Diagnostics
- Cardiovascular Issues in Pregnancy
- Sensor Technology and Measurement Systems
- Cardiovascular and Diving-Related Complications
- Coronary Interventions and Diagnostics
- Coronary Artery Anomalies
- Tracheal and airway disorders
- Cardiomyopathy and Myosin Studies
- Advanced MEMS and NEMS Technologies
- Cardiac Ischemia and Reperfusion
- Peripheral Artery Disease Management
- Congenital Diaphragmatic Hernia Studies
- Geophysics and Sensor Technology
- Hip and Femur Fractures
- Heart Failure Treatment and Management
KU Leuven
2015-2025
Institutul de Urgenţă pentru Boli Cardiovasculare "Prof.Dr. C.C. Iliescu"
2015
Abstract Fontan-Associated Liver Disease (FALD) is a dramatically emerging problem even if not precisely defined in term of debated diagnosis and surveillance protocols. We analyze FALD prevalence, clinical impact implications European cohort patients. It’s retrospective observational multicenter study including Fontan patients operated between 1990 2022. Anatomical, clinical, surgical liver-related data were collected, defining as spectrum time-related structural–functional liver...
Decellularized pulmonary homografts (DPH) have shown excellent results for valve replacement. However, controlled multicentre studies are lacking to date.Prospective European trial evaluating DPH Matched comparison of bovine jugular vein (BJV) conduits and cryopreserved (CH) considering patient age, type heart defect previous procedures.In total, 121 patients (59 female) were prospectively enrolled (August 2014-December 2016), age 21.3 ± 14.4 years, diameter 24.4 2.8 mm. No adverse events...
Recent studies have shown that aortic diameter alone is an insufficient parameter to identify patients at risk for dissection. The aim of this study was determine the value ratio medial wall thickness as a new marker risk.We obtained data from 181 with ascending aneurysm (n = 94) or acute type A dissection 87), surgically treated our institution (1996-2012). Measurements maximum and were conducted by retrospective review preoperative imaging histological specimens, respectively.Nearly 60%...
In recent years, the Heartmate 3 (HM3) has largely replaced use of other intracorporeal left ventricular assist devices in adult field. Because HM3 is larger than Heartware Ventricular Assist Device, general consensus was that for small patients, Device most appropriate implantable device option. Our goal to describe our experiences with successful implantation 2 children, aged 9 and 11. We report on chest cavity dimensions, as measured computed tomography, can be used assess feasibility patients.
Abstract Background Mechanical factors may cause bottlenecks in a Fontan circuit. Extracardiac conduits (ECC) are placed at young age, but the materials do not allow growth. Restriction ECC dimensions deteriorate function of Aims This study aimed to evaluate feasibility and safety stent expansion an nominal dimension time implant and, if possible, beyond nominal. Methods Retrospective, single‐center observational review all patients who received expand previously surgical conduit. Results A...
Abstract OBJECTIVES To investigate if there is still a place for bioprosthetic mitral valve replacement in children by comparing the prosthetic durability and transplant-free survival after mechanical replacement. METHODS We reviewed all replacements between 1981 2020. Bioprosthetic cases were individually matched to cases. The incidence rate of 2nd was calculated using cumulative function that considered death or transplantation as competing risk. RESULTS median age at implantation 3.6...
Background: Pacing the right heart has been shown to induce reversible conduction delay and subsequent asymmetric remodeling of left ventricle (LV) in dogs pigs. Both species have disadvantages animal experiments. Therefore aim this study was develop a more feasible easy-to-use model sheep. Methods: Dual-chamber (DDD) pacemakers with epicardial leads on atrium ventricular free wall were implanted 13 All animals underwent 8 weeks chronic rapid pacing at 180 bpm. Reported observations made...
Patients with a single ventricle survive thanks to the Fontan palliation. Nevertheless, there is growing number of patients progressive heart failure. To validate therapeutic options in these patients, we developed chronic large animal model.A circulation was surgically created 15 sheep. The superior vena cava anastomosed end-to-side pulmonary artery. inferior connected artery by an ePTFE conduit, and cava-right atrium junction ligated.Total cavopulmonary connection successfully performed...
The study objective was to analyze survival and incidence of Fontan completion patients with single-ventricle concomitant unbalanced atrioventricular septal defect.Data from 4 Dutch 3 Belgian institutional databases were retrospectively collected. A total 151 defect selected; 36 underwent an valve procedure (valve surgery group). End points survival, completion, freedom reoperation.Median follow-up 13.4 years. Cumulative 71.2%, 70%, 68.5% at 10, 15, 20 years, respectively. An not a risk...
In the sheep model with pathophysiologic changes similar to patients repaired TOF, severe PR leads fibrotic in RV. Pulmonary valve replacement reverses these changes. Early led a quick RV recovery, and time there was no difference outcome between early late replacement. These data support benefit of for function suggest that is margin timing surgery. The correlated well circulating biomarker PICP, which can have an added value clinical follow-up TOF.
Abstract OBJECTIVES This study aims to identify causes of failure in Fontan patients with a total cavopulmonary connection. METHODS We conducted comprehensive review all who underwent connection procedure at our centre between 1988 and 2023, aiming analyze the factors contributing (defined as mortality, heart transplantation, takedown, protein-losing enteropathy, plastic bronchitis, or New York Heart Association Functional Classification class III IV). RESULTS The included 217 (median age...
Background In the present work, we investigated exercise capacities of patients with partial flow left ventricular assist devices and its evolution over time. We then compared these those full support device patients. Methods retrospectively analysed data maximal cardiopulmonary tests ten (CircuLite Synergy® Micropump) collected before (PS0), at 3 (PS3) 6 months (PS6) after implantation. The were 17 (FS6) treated a (HeartMate II, Thoratec©). For this analysis, considered performed pump...
Purpose: To investigate the relationship between two measures of regional myocardial workload (RMW): glucose metabolism, assessed by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and LV pressure-strain loop area.Both were evaluated in a chronic rapid pacing animal model dilated cardiomyopathy (DCM) LBBB-like mechanical dyssynchrony.Methods: Nine sheep subjected to RV (180 bpm), developing dilatation asymetric remodelling, with ventricular activation.After 8 weeks all...
Right-sided mechanical support of the Fontan circulation by existing devices has been compounded cross-sectional design vena cava anastomosis to both pulmonary arteries. Our purpose was investigate whether increasing inferior (IVC) flow with a rotary blood pump in IVC only an ovine animal model would lead acceptable superior (SVC) pressure. To achieve this, established four female sheep anastomosing SVC main artery (MPA) and interposing Dacron graft between MPA. A then introduced graft,...
The use of ventricular assist devices (VADs) in children is increasing. However, absolute numbers individual centres and countries remain small. Collaborative efforts such as the Paedi-European Registry for Patients with Mechanical Circulatory Support (EUROMACS) are therefore essential combining international experience paediatric VADs. Our goal was to present results from fourth Paedi-EUROMACS report.
Abstract Background In Fontan patients, the slope of invasively measured pulmonary artery pressures plotted against cardiac output (CO) during exercise has prognostic significance. We propose a methodology using echocardiography combined with cardiopulmonary testing and simultaneous peripheral venous pressure measurements (CPET-echo-PVP) to calculate PVP/CO slopes as non-invasive alternative. Purposes This study aimed at assessing (1) (2) their relationship peak oxygen consumption in...