A5019708374- Cardiovascular Function and Risk Factors
- Viral Infections and Immunology Research
- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Cardiac Valve Diseases and Treatments
- Kawasaki Disease and Coronary Complications
- Multiple Sclerosis Research Studies
- Aortic Disease and Treatment Approaches
- Pulmonary Hypertension Research and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Pericarditis and Cardiac Tamponade
- Liver Disease and Transplantation
- Connective tissue disorders research
- Cardiomyopathy and Myosin Studies
- Gastrointestinal motility and disorders
- Congenital heart defects research
- Global Health Care Issues
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Vascular Anomalies and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Abdominal vascular conditions and treatments
- SARS-CoV-2 and COVID-19 Research
Bambino Gesù Children's Hospital
2014-2025
University of Parma
2022-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2024
Universidade Estadual de Campinas (UNICAMP)
2021
Cytodiagnostics (Canada)
2015
Agostino Gemelli University Polyclinic
1975
Summary Purpose Our aim is to compare new non‐invasive imaging modalities in the evaluation of vascular ring (VR) and pulmonary artery sling (PAS) understand role bronchoscopy comparison with them assessing tracheobronchial tree. Methods We have retrospectively analyzed data from 41 patients a VR or PAS diagnosed at Bambino Gesù Children's Hospital Rome, between 2008 2012. Age, gender, presenting symptoms, clinical history, comorbidities, used for diagnosis (cardiac magnetic resonance [CMR],...
Newer parameters of cardiac mechanics provide additional insights on dysfunction in adult patients with CKD. The aim this study was to identify prevalence subclinical abnormalities function through the analysis novel indices a large population children
In pediatric liver recipients perioperative factors may affect respiratory and cardiac function, prolong mechanical ventilation during post-operative period. The use of NAVA can improve the interaction between patient ventilator from both a perspective. objective this study is to evaluate synchronization ventilator, as well application neurally adjusted ventilatory assist (NAVA) pressure support (PSV) in transplant recipients. This single-center, prospective, randomized, physiological...
Abstract Background and aim Epidermolysis bullosa simplex (EBS) is a rare inherited blistering disease mutations in kelch–like protein 24 (KLHL24) were recently implicated unique subtype of EBS [1,2]. KLHL24 expressed at similar levels keratinocytes cardiomyocytes. There growing association dilated cardiomyopathy EBS–KLHL24 that may be severe usually present early adulthood. We to describe the pediatric onset scarring cardiomyopathies (CMP) patients. Case reports report two cases mutation...
Abstract We report the case of a 16–year–old patient, admitted at Bambino Gesù Hospital for cardiogenic shock. He was competitive athlete with history sporadic episodes myalgias and elevated CPK. One week before he had an episode headache prolonged fasting during which performed intense workout. presented to ED asthenia, chest pain hypotension. The electrocardiogram showed sinus rhythm, normal PR QTc intervals low QRS complexes voltages in precordial leads. echocardiography detected severe...
Abstract The aim here was to describe the role of speckle tracking echocardiography (STE), in identifying impairment systolic function children and adolescents with focal myocarditis without reduction ejection fraction. We data from 33 pediatric patients (age 4–17 years) admitted for myocarditis, confirmed by cardiac magnetic resonance (CMR), impaired fraction and/or wall motion abnormalities. All underwent Doppler examination analysis global (G) segmental longitudinal strain (LS) CMR...
A third paediatric report has been generated from the European Registry for Patients with Mechanical Circulatory Support (EUROMACS). The purpose of EUROMACS, which is operated by Association Cardio-Thoracic Surgery, to gather data related durable mechanical circulatory support scientific purposes and publish reports respect course therapy. Since first issued, efforts increase compliance participation have extended. Additionally, provided opportunity analyse patients younger age lower...
Despite the multiple benefits of vaccination, cardiac adverse Events Following COVID-19 Immunization (c-AEFI) have been reported. These events as well severe involvement reported in Multisystem inflammatory syndrome children (MIS-C) appear more frequent young adult males. Herein, we firstly report on profiles patients experiencing c-AEFI comparison with age, pubertal age and gender matched MIS-C involvement. Proteins related to systemic inflammation were found higher compared c-AEFI, whereas...
Whilst there has been significant public health benefits associated with global use of COVID-19 spike protein vaccines, potential serious adverse events following immunization have reported. Acute myocarditis is a rare complication COVID19 vaccines and often it self-limiting. We describe two cases experiencing recurrent mRNA vaccine despite prior episode full clinical recovery. Between September 2021-September 2022 we observed male adolescents related to mRNA-based-COVID19 vaccine. During...
Marfan syndrome (MIM: # 154700; MFS) is an autosomal dominant disease representing the most common form of heritable connective tissue disorder. The condition presents variable multiorgan expression, typically involving a triad cardiovascular, eye, and skeletal manifestations. Other multisystemic features are often underdiagnosed. Moreover, characterized by age related penetrance. Diagnosis management MFS in adult population well-described literature. Few studies focused on pediatric...
Acute pericarditis/myocarditis is a rare complication of the mRNA-based vaccines and although mostly self-limiting, long-term sequelae remain unclear.We enrolled all patients admitted to emergency department between September 2021 February 2022 meeting CDC work case definition, with symptoms onset after COVID-19 vaccine. Alternative virologic causes were excluded. Clinical data, laboratory values, cardiologic evaluation, electrocardiogram (ECG), echocardiogram (ECHO) collected on admission,...
Sotos syndrome is an autosomal dominant condition characterized by overgrowth with advanced bone age, macrodolicocephaly, motor developmental delays and learning difficulties, characteristic facial features caused heterozygous pathogenetic variants in the NSD1 gene located on chromosome 5q35. The prevalence of heart defects (HDs) individuals estimated to be around 15–40%. Septal patent ductus arteriosus are most commonly diagnosed malformations, but complex have also been reported. aim our...
This study was designed to evaluate the difference in prevalence of long-term arterial hypertension among patients with corrected aortic coarctation according existence associated cardiac congenital lesions.We identified 235 who had undergone surgery for and classified them into 2 groups: isolated aorta (CoA) complex heart disease. Data were retrospectively analysed.There 148 subjects CoA 87 (CoA-c). Patients defined as hypertensive if they required antihypertensive treatment and/or when...
Jacobsen syndrome (JS) is a rare caused by deletion of chromosome 11q. We report patient with JS and hypoplastic left heart (HLHS) who required cardiac transplantation. She had many the recognized morphological features in addition to immunological (lymphopenia) hematological (thrombocytopenia) issues. The underwent Norwood procedure modified Blalock–Taussig shunt (MBTS) subsequently Glenn at six months age. developed desaturation, severe tricuspid regurgitation right ventricular...
Conventional echocardiography is an essential tool for the diagnosis, bedside management and follow-up evaluations of children with multisystem inflammatory syndrome associated COVID-19. However, a more comprehensive echocardiographic exam, including myocardial deformation parameters, may allow early identification subtle changes in ventricular function, provide risk stratification and, identify sub-clinical cardiac dysfunction at follow-up. Thus, analysis should be routinely integrated to...
Background: multiple sclerosis (MS) has an extremely heterogeneous disease course. Relapsing course leading to rapid accrual of physical and cognitive disability, often despite treatment, is referred as "aggressive" disease. Case presentation: definition treatment aggressive are poorly standardized. No clear reports ocrelizumab in tumefactive, breakthrough available current literature. report: a 34-year-old Caucasian woman was admitted hospital with dizziness, nausea, vomiting, mild gait...
The use of ventricular assist devices (VADs) in children is increasing. However, absolute numbers individual centres and countries remain small. Collaborative efforts such as the Paedi-European Registry for Patients with Mechanical Circulatory Support (EUROMACS) are therefore essential combining international experience paediatric VADs. Our goal was to present results from fourth Paedi-EUROMACS report.
Cardiovascular involvement has a great impact on morbidity and mortality in sickle cell disease (SCD). Currently, few studies are available regarding the paediatric setting and, moreover, current guidelines for echocardiogram screening program asymptomatic population controversial. We performed retrospective observational monocentric study 64 SCD patients (37 male 27 female, median age 10) at Bambino Gesù Childrens' Hospital, who had undergone routine transthoracic echocardiogram. In total,...