A5066249862- Cancer Genomics and Diagnostics
- Heart Failure Treatment and Management
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Colorectal Cancer Treatments and Studies
- Infective Endocarditis Diagnosis and Management
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Pharmaceutical studies and practices
- Genetics and Neurodevelopmental Disorders
- Cardiac Imaging and Diagnostics
- Cardiomyopathy and Myosin Studies
- Potassium and Related Disorders
- Viral Infections and Immunology Research
- Cardiovascular Effects of Exercise
- Lung Cancer Treatments and Mutations
- Cardiac pacing and defibrillation studies
- Eicosanoids and Hypertension Pharmacology
- Axon Guidance and Neuronal Signaling
- Hepatocellular Carcinoma Treatment and Prognosis
- Abdominal Trauma and Injuries
- Political Theory and Democracy
- Mechanisms of cancer metastasis
- Cancer, Hypoxia, and Metabolism
University of Campania "Luigi Vanvitelli"
2022
Magna Graecia University
2003-2021
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2009-2021
Bambino Gesù Children's Hospital
2014-2020
Ospedale San Carlo
2015
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2013
Centro di Riferimento Oncologico
2012-2013
Istituto Superiore di Sanità
2006
University of Michigan
1998
University of Utah
1998
Abstract Increasing evidence demonstrates that target‐based agents are active only in molecularly selected populations of patients. Therefore, the identification predictive biomarkers has become mandatory to improve clinical development these novel drugs. Mutations epidermal growth factor receptor (EGFR) or rearrangements ALK gene non‐small‐cell lung cancer, and BRAF mutations melanoma clear examples driver response treatment with specific inhibitors. Predictive might also identify subgroups...
The activity of the epidermal growth factor receptor (EGFR) antibodies cetuximab and panitumumab in metastatic colorectal carcinoma (mCRC) is significantly limited by molecular mechanisms leading to intrinsic or acquired resistance. S492R mutation EGFR, which caused either 1476C>A 1474A>C substitution, interferes with binding but not panitumumab, has been detected mCRC resistance cetuximab. Since EGFR monoclonal CRC overlap, we evaluated frequency a series KRAS-exon 2 wild-type patients....
Aim: We assessed the ability of Therascreen® kit (plasma-Therascreen) and a peptide nucleic acids (PNA)-clamp approach to detect EGFR mutations in plasma-derived circulating-free tumor DNA (cftDNA) from non-small-cell lung cancer patients. Materials & methods: cftDNA 96 patients was analyzed for exon 19 deletions p.L858R mutation, using both plasma-Therascreen PNA-clamp-based assays. Results: None 70 wild-type showed with techniques (specificity: 100%). In 17/26 EGFR-mutant patients,...
Abstract The aim here was to describe the role of speckle tracking echocardiography (STE), in identifying impairment systolic function children and adolescents with focal myocarditis without reduction ejection fraction. We data from 33 pediatric patients (age 4–17 years) admitted for myocarditis, confirmed by cardiac magnetic resonance (CMR), impaired fraction and/or wall motion abnormalities. All underwent Doppler examination analysis global (G) segmental longitudinal strain (LS) CMR...
Arrhythmogenic Right Ventricular cardiomyopathy (ARVC) is an inherited cardiac muscle disease linked to genetic deficiency in components of the desmosomes. The characterized by progressive fibro-fatty replacement right ventricle, which acts as a substrate for arrhythmias and sudden death. molecular mechanisms underpinning ARVC are largely unknown. Here we propose mathematical model investigating dynamics underlying heart remodeling loss myocytes identity during ARVC. Our methodology based on...
Here, we described the generation of human induced pluripotent stem cell lines (hiPSCs) from fibroblasts isolated by punch biopsies two siblings carrying inherited mutation (c.434 T > C) in SCN1A gene, encoding for neuronal voltage gated sodium channel NaV1.1. The leads to substitution a highly conserved methionine with threonine (M145T) protein sequence, leading infant febrile seizures (FS). older brother, affected complex FS, also developed temporal lobe epilepsy (TLE) during adolescence.
Abstract Pluripotent cells within embryonal carcinoma (EC) can differentiate in vivo or vitro on treatment with specific agents. Differentiating EC express lower levels of stem cell–related genes, such as Cripto-1. We show that migration human (NTERA/2 and NCCIT) be reduced following the guidance molecule Netrin-1. Moreover, Netrin-1 increased β-III tubulin, glial filament acidic protein, Nestin, γ-aminobutyric acid expressions Cripto-1, Nanog, Oct4 cells. These Netrin-1–induced effects were...
Unverricht-Lundborg disease (ULD) is an inherited form of progressive myoclonus epilepsy caused by mutations in the gene encoding Cystatin B (CSTB), inhibitor lysosomal proteases. The most common mutation described ULD patients unstable expansion a dodecamer sequence located CSTB promoter. This causative downregulation expression and, consequently, its inhibitory activity. Here we report generation induced pluripotent stem cell (iPSC) lines from two Italian siblings having family history and...
Development and maintenance of neuronal shape depend on regulated assembly disassembly microtubules. Microtubule-associated proteins (MAPs) bind to microtubules, regulate microtubule disassembly, play critical roles in development the balance between axonal plasticity stability. In general, MAPs that are present postnatally (e.g., MAP1a) considered enhance (and axonal) stability.1 Disturbance MAP structure or function could contribute degenerative neurologic disorders such as hereditary...
Perrone, Marco A.; Chinali, Marcello; del Pasqua, Alessia; Esposito, Claudia; Ciliberti, Paolo; Trezzi, Matteo; Albanese, Sonia; Romeo, Francesco; Rinelli, Gabriele Author Information
Abstract BACKGROUND Strain echocardiography is a reliable echocardiographic modality to measure myocardial mechanical deformation and evaluate regional global systolic function, has been demonstrated be useful tool for the evaluation of cardiac function in children with acquired congenital heart diseases. Recent advancements technology allow analyze strain multiple layers. To our knowledge, there are no published reference values multilayer-specific measurement. AIM OF THE STUDY Aim study...
La valutazione della funzione cardiaca e di importanza fondamentale nei pazienti con trapianto cardiaco. Abbiamo analizzato 60 pediatrici sottoposti a cardiaco 30 volontari sani simile distribuzione eta’ sesso. I sono stati studio ecocardiografico transtoracico completo metodica speckle tracking bidimensionale ed ecografia tridimensionale per lo sincronia ventricolare. nostri risultati suggeriscono che la sistolica del ventricolo trapiantato e’ significativamente diversa rispetto quella...