Mounting evidence suggests that immune-system dysfunction and inflammation play a role in the pathophysiology treatment of mood-disorders general bipolar disorder particular. The current study examined effects chronic low-dose aspirin lithium (Li) on plasma brain interleukin-6 tumor necrosis factor-α production lipopolysaccharide (LPS)-treated rats. Rats were fed regular or Li-containing food (0.1%) for six weeks. Low-dose (1 mg/kg) was administered alone together with Li. On days 21 42 rats...

Abstract Background From October 7, 2023, until August 28, 2024, 187 posthumous sperm retrieval (PSR) procedures have been conducted on deceased men, 171 of whom are soldiers. PSR was predominantly initiated by parents to cope with their profound loss. However, the attitudes Israeli men toward this procedure unknown. Objective This study aims investigate prior consent and posthumous‐assisted reproduction (PAR) partner or parents. Methods A cross‐sectional 600 aged 18–49 years who were...

Despite established efficacy in bipolar disorder patients, lithium (Li) therapy has serious side effects, particularly chronic kidney disease. We examined the safety and behavioral effects of combined low-dose aspirin plus Li rats to explore toxicity therapeutic potential this treatment. Rats were fed regular or Li-containing food (0.1% [low-dose, LLD-Li] 0.2% [standard-dose, STD-Li]) for six weeks. Low-dose (1 mg/kg) was administered alone together with Li. Renal function gastric mucosal...

Traumatic brain injury (TBI) is a major cause of death and disability. Diffuse axonal (DAI) the predominant mechanism in large percentage TBI patients requiring hospitalization. DAI involves widespread damage from shaking, rotation or blast injury, leading to rapid stretch secondary changes that are associated with long-lasting impact on functional recovery. Historically, experimental models without focal have been difficult design. Here we validate simple, reproducible reliable rodent model...

Ondansetron is a widely administered medication for nausea and vomiting of pregnancy. Further examination its teratogenic capacity necessary. This study examines the association between ondansetron treatment during pregnancy birth defects adverse obstetric outcomes. Patient data were extracted from Clalit Health Services, Israel. A propensity-score analysis was performed matching those exposed to with who not. Findings identified 774 women ondansetron, matched 1:1 unexposed control patients....

In Israel there are only 6.53 nurses per 1000 citizens, compared to 8.8 citizens in the OECD countries. The nursing shortage is even more severe peripheral areas, especially southern Israel. Nurses` professional satisfaction crucial for preserving workforce. This study aimed assess job among novice and identify components of satisfaction.Cross-sectional 216 who graduated 2018-2022 were approached ten months after graduation. Job constructed using factor analysis.Professional was based mainly...

<title>Abstract</title> Background Over the past 20 years, Jewish and Bedouin civilians in southern Israel have faced ongoing threat of missile attacks from Gaza, with possible mental health consequences. This study aimed to assess prevalence post-traumatic stress disorder (PTSD) among adult a period few no military operations. Methods The population included 389 participants (246 Jews, 143 Bedouins) living within 40 km/25 mi Gaza for at least two years interviewed between January March 2023...

Bipolar disorder (BD) is a chronic mental disease that substantially affects the patient's quality of life and causes significant morbidity mortality. Although there are variety available treatments, therapeutic intervention not beneficial in many cases recurrence rates remain high. Recent data suggested tamoxifen, drug with wide range activities, as potential treatment for reducing manic symptoms BD. Tamoxifen's effect on bipolar mania has been fully elucidated, but it believed to...

Abstract At any given moment, a notable proportion of parents worldwide have at least one child serving in the military. The aim this study is to assess prevalence depression, anxiety, and stress sample Israeli soldiers difference by type service (combat vs. non‐combat) other demographic characteristics soldiers. A cross‐sectional convenience 202 who were interviewed during January‐September 2023. Depression Anxiety Stress Scale (DASS‐21) was used measure emotional states (with cut‐off...

Background: Fabricating data or creating fictitious datasets undermines research credibility with severe consequences. Purpose: To describe a falsification incident that occurred during an undergraduate nursing seminar and share the subsequent corrective measures employed at individual class levels. Methods: The students involved in were asked to identify incident’s factors using Ishikawa diagram 5M-Model approach, presenting their findings class. Results: In guided meetings, offered diverse...

Abstract Background Over the past 20 years, Jewish and Bedouin civilians in southern Israel have faced ongoing threat of missile attacks from Gaza, with possible mental health consequences. This study aimed to assess prevalence post-traumatic stress disorder (PTSD) among adult a period few no military operations. Methods The population included 389 participants (246 Jews, 143 Bedouins) living within 40 km/25 mi Gaza for at least 2 years interviewed between January March 2023 (before war that...

Abstract Background Preserving new graduate nurses in the profession is an essential step for addressing nursing shortage and sustaining future of profession. This study aimed to examine relationship between employment characteristics job satisfaction novice their willingness stay next 5 years. Methods Novice nurses’ intention was assessed, considering demographics, characteristics, components satisfaction. Among sample 216 (93% response rate), four were extracted included multivariable...

Traumatic brain injury (TBI) is a major cause of death and disability. Diffuse axonal (DAI) the predominant mechanism in large percentage TBI patients requiring hospitalization. DAI involves widespread damage from shaking, rotation or blast injury, leading to rapid stretch secondary changes that are associated with long-lasting impact on functional recovery. Historically, experimental models without focal have been difficult design. Here we validate simple, reproducible reliable rodent model...

Abstract Background: In Israel there are 5.0 nurses per 1,000 citizens, which is low compared to 9.3 in the OECD countries. The nursing shortage even more severe peripheral areas (especially southern Israel). Nurses` professional satisfaction crucial for preserving workforce. study aimed assess job among novice and identify components of satisfaction. Methods: Cross-sectional 216 nurses, who graduated 2018-2022 were approached ten months after graduation. Job constructed using factor...

Abstract Soon after the coronavirus disease 2019 (COVID‐19) pandemic outbreak, it became clear that vaccination will be most useful tool to combat disease. Despite apparent safety and efficacy of developed anti‐COVID‐19 vaccines, relatively high percentages population worldwide refused get vaccinated, including many health workers students. The present cross‐sectional study examined motives, attitudes, personal characteristics those who did not vaccinated against COVID‐19 or without complete...

Objective: To examine whether co-administration of clopidogrel and omeprazole affects the clinical outcomes treatment. Design Methods: A retrospective cross-sectional study 4078 patients after a percutaneous coronary intervention stent implantation. Seven hundred twenty-three clopidogrel-treated who fulfilled inclusion criteria were included: 318 treated only with clopidogrel; 405 (study group). The interaction between drugs was examined in relation to adverse such as all-cause mortality,...