A5051585571- Mitochondrial Function and Pathology
- Cardiovascular Function and Risk Factors
- Metabolism, Diabetes, and Cancer
- Cardiac Ischemia and Reperfusion
- Adipose Tissue and Metabolism
- ATP Synthase and ATPases Research
- Metabolism and Genetic Disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Sirtuins and Resveratrol in Medicine
Université de Caen Normandie
2016-2023
Normandie Université
2017-2023
Centre Hospitalier Universitaire de Caen Normandie
2017-2023
Abstract Background MEGDHEL is an autosomal recessive syndrome defined as 3‐MEthylGlutaconic aciduria (3‐MGA) with Deafness, Hepatopathy, Encephalopathy, and Leigh‐like on magnetic resonance imaging, due to mutations in the SERAC1 (Serine Active Site Containing 1) gene, which plays a role mitochondrial cardiolipin metabolism. Methods We report case of young patient who presented convulsive encephalopathy, 3‐methylglutaconic aciduria, deafness, bilateral T2 hypersignals putamen thalami,...
Aims Glycemic variability has been suggested as a risk factor for diabetes complications but the precise deleterious mechanisms remain poorly understood. Since mitochondria are main source of energy in heart and cardiovascular diseases first cause death patients with diabetes, aim study was to evaluate impact glucose swings on mitochondrial functions cardiomyocyte cell line HL-1. Methods HL-1 cells were exposed low (LG, 2.8 mmol/l), normal (NG, 5.5 high (HG, 25 mmol/l) or intermittent (IHG,...