A5044271874- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Pharmacological Receptor Mechanisms and Effects
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Hormonal Regulation and Hypertension
- Cardiovascular Function and Risk Factors
- Cardiac Ischemia and Reperfusion
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- ATP Synthase and ATPases Research
- Iron Metabolism and Disorders
- Protein Hydrolysis and Bioactive Peptides
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- COVID-19 Clinical Research Studies
- Cardiac Imaging and Diagnostics
- Cancer, Stress, Anesthesia, and Immune Response
- Diet and metabolism studies
- Genomics and Rare Diseases
- Neurological diseases and metabolism
Centre Hospitalier Universitaire de Caen
2015-2024
Université de Caen Normandie
2015-2024
Normandie Université
2014-2023
Laboratoire de Biochimie Théorique
2008-2022
Cyceron
2016
Centre National de la Recherche Scientifique
1994-2014
Leiden University Medical Center
2012
Loughborough University
2012
Babraham Institute
2012
University of Glasgow
2012
Background Immune checkpoint inhibitor (ICI)-associated early cardiac adverse events (CAEs), mostly acute and fulminant myocarditis, have been well characterized mainly occur during the first 90 days after ICI therapy initiation. ICI-associated late CAEs (occurring of treatment) not yet described. Methods First, we compared characteristics a cohort involving (defined as CAE time to onset (TTO) <90 initiation) TTO ≥90 consecutive cases who were referred three French cardio-oncology units....
The prediction of neurological outcome in comatose patients after cardiac arrest has major ethical and socioeconomic implications. purpose this study was to assess the capability serum neuron-specific enolase (NSE), a biomarker hypoxic brain damage, predict death or vegetative state cardiac-arrest survivors. We conducted prospective observational cohort one university hospital general Intensive Care Unit (ICU). All consecutive who suffered were subsequently admitted from June 2007 February...
Despite its central role in modern medicine, medical biology tends to attract fewer future physicians. The reasons for this disinterest are varied: a lack of awareness about the specialty among students, medico-technical nature field, financialization private healthcare structures, and regulatory requirements, such as implementation demanding quality systems that distance students from issues. Since 2018-2019 academic year, workshop has been integrated into problem-based learning sessions...
Abstract Distal hereditary motor neuropathy represents a group of inherited neuropathies leading to distal weakness. We report family two brothers and sister affected by in whom homozygous variant c.3G&gt;T (p.1Met?) was identified the COQ7 gene. This gene encodes protein required for coenzyme Q10 biosynthesis, component respiratory chain mitochondria. Mutations were previously associated with severe multi-organ disorders characterized early childhood onset developmental delay. Using...
Phosphorylation of G protein-coupled receptors is considered an important step during their desensitization. In SK-N-BE cells, recently presented as a pertinent model for the studies human delta-opioid receptor, pretreatment with opioid agonist etorphine increased time-dependently rate phosphorylation 51-kDa membrane protein. Immunological characterization this protein antibody, raised against amino-terminal region cloned revealed that it corresponded to receptor. During prolonged treatment...
Desensitization and internalization of G protein-coupled receptors observed after agonist activation are considered two important regulatory processes receptor transduction. Endogenous human δ-opioid (hDOR) differentially regulated in terms desensitization by peptide ([d-Pen2,5]enkephalin (DPDPE) Deltorphin I) alkaloid (etorphine) agonists the neuroblastoma cell line SK-N-BE (Allouche, S., Roussel, M., Marie, N., Jauzac, P. (1999) Eur. J. Pharmacol. 371, 235–240). In present study, we...
Postoperative atrial fibrillation (POAF) is associated with poor outcomes after coronary artery bypass graft (CABG) surgery. We aimed to assess the additional value of preoperative plasma aldosterone levels, a biomarker promoting proarrhythmic and profibrotic pathways, for predicting POAF CABG.We conducted prospective cohort study involving consecutive patients left ventricular ejection fraction (LVEF) more than 50% requiring elective CABG in our university hospital. Plasma two-dimensional...
Background and purpose: δ‐Opioid receptors (DOP receptors) could represent a novel target in the treatment of depressive disorders. To explore this new field interest, development highly selective DOP receptor agonists is essential. UFP‐512 [H‐Dmt‐Tic‐NH‐CH(CH 2 ‐COOH)‐Bid], was recently shown to behave vitro as potent agonist promote antidepressant‐ anxiolytic‐like effects vivo ( Vergura et al. , 2007 ). Here, we have characterized pharmacological properties established link between...
Vemurafenib, an anti-rapidly accelerated fibrosarcoma kinase B (BRAF) molecule, improves survival among patients with metastatic BRAF-mutated melanoma. Photosensitivity, a frequent cutaneous adverse effect induced by vemurafenib, can lead to cessation of treatment.To investigate photosensitivity mechanisms in treated vemurafenib for melanoma.In prospective study 12 patients, photobiological explorations measurements ultraviolet A (UVA) minimal erythema dose (MED) and polychromatic MED were...
Background and Purpose: Cardioprotection against ischemia–reperfusion (I/R) damages remains a major concern during prehospital management of acute myocardial infarction. Noble gases have shown beneficial effects in preconditioning studies. Because emergency proceedings the context infarction require postconditioning strategies, we evaluated argon such protocols on mammalian cardiac tissue. Experimental Approaches: In rat, I/R was induced vivo by transient coronary artery ligature functions...
Abstract Objective The objective of this study was to evaluate the implementation NGS within French mitochondrial network, MitoDiag, from targeted gene panels whole exome sequencing (WES) or genome (WGS) focusing on nuclear‐encoded genes. Methods Over 2000 patients suspected Primary Mitochondrial Diseases (PMD) were sequenced by either panels, WES WGS MitoDiag. We described clinical, biochemical, and molecular data 397 genetically confirmed patients, comprising 294 children 103 adults,...
Differences in the specificity of coupling delta-opioid receptor with G-protein have been reported literature. We observed a differential desensitization receptors, endogenously expressed neuroblastoma cell line SK-N-BE, induced by peptide and alkaloid agonists. By combining photoaffinity labelling receptor-activated G-proteins [alpha-(32)P]azidoanilide-GTP an anti-sense oligodeoxynucleotide strategy, we examined whether chemical nature opioid agonists, or peptide, has critical role...
Among the different mechanisms underlying opioid tolerance, receptor desensitization would represent a major cellular adaptation process in which role of internalization is still matter debate. In present study, we examined human δ-opioid (hDOR) produced by endogenous peptides Leu-enkephalin (Tyr-Gly-Gly-Phe-Leu) and Met-enkephalin (Tyr-Gly-Gly-Phe-Met), contribution this process. Results obtained with natural were compared those synthetic agonist, SNC-80...
The A3243G mutation in the tRNALeu gene (UUR), is one of most common pathogenic mitochondrial DNA (mtDNA) mutations France, and associated with highly variable heterogeneous disease phenotypes. To define relationships between mtDNA backgrounds, we determined haplogroup affiliation 142 unrelated French patients - diagnosed as carriers by control-region sequencing RFLP survey their mtDNAs.The analysis revealed 111 different haplotypes encompassing all European haplogroups, indicating that 3243...