A5036193925- Photopolymerization techniques and applications
- Material Properties and Applications
- Liquid Crystal Research Advancements
- Polymer Synthesis and Characterization
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pigment Synthesis and Properties
- Thermal and Kinetic Analysis
- Nitric Oxide and Endothelin Effects
- Advanced Polymer Synthesis and Characterization
- Mitochondrial Function and Pathology
- Vitamin K Research Studies
- Adsorption, diffusion, and thermodynamic properties of materials
- Eicosanoids and Hypertension Pharmacology
- Metabolism and Genetic Disorders
- Synthesis and properties of polymers
- Surfactants and Colloidal Systems
- Renin-Angiotensin System Studies
- Receptor Mechanisms and Signaling
- Hemophilia Treatment and Research
- Inorganic and Organometallic Chemistry
- European and International Law Studies
- Radiation Effects and Dosimetry
- Biopolymer Synthesis and Applications
- Corporate Governance and Law
- Inflammatory mediators and NSAID effects
Université Grenoble Alpes
2005-2025
Centre Hospitalier Universitaire de Grenoble
2004-2025
Université d'Angers
2024
Laboratoire de Microbiologie et Génétique Moléculaires
2024
Université des Antilles
2023
Laboratoire National de Référence
2018
Tianjin Plastics Research Institute
1981-2007
Physiopathologie et Epidémiologie des Maladies Respiratoires
2005
Inserm
2005
Tricoci University of Beauty Culture
2005
<h3>Abstract</h3> <h3>Background</h3> Mitochondrial DNA (mtDNA) diseases are rare disorders whose prevalence is estimated around 1 in 5000. Patients usually tested only for deletions and common mutations of mtDNA which account 5–40% cases, depending on the study. However, not known. <h3>Methods</h3> We analysed whole a cohort 743 patients suspected manifesting mitochondrial disease, after excluding mutations. Both heteroplasmic homoplasmic variants were identified using two complementary...
Abstract Background When a member of family has been diagnosed with hereditary angioedema (HAE) before child is born, the question early diagnosis arises. Indeed, first attacks may occur at birth. Early complicated by biological issues. Due to immaturity complement system, C1 Inhibitor (C1 INH) and C4 levels can be low birth, generally in range 60 100% adult reference values. Like most proteins, their normalize after one year life. However, this not always case, we report two...
6-Thioguanine (6-tioguanine) nucleotides are the active metabolites of azathioprine.The aim study was to evaluate rate clinical remission without steroids in steroid-dependent Crohn's disease and ulcerative colitis patients receiving azathioprine, medium- long-term efficacy predictive factors response when monitoring 6-tioguanine.Steroid-dependent either azathioprine or not (treated later with a daily dose 2.5 mg/kg) were prospectively included. 6-tioguanine monitored at 1 2 months every 3...
Abstract Objective The objective of this study was to evaluate the implementation NGS within French mitochondrial network, MitoDiag, from targeted gene panels whole exome sequencing (WES) or genome (WGS) focusing on nuclear‐encoded genes. Methods Over 2000 patients suspected Primary Mitochondrial Diseases (PMD) were sequenced by either panels, WES WGS MitoDiag. We described clinical, biochemical, and molecular data 397 genetically confirmed patients, comprising 294 children 103 adults,...
Angiotensin II (Ang II) is a vasopressor peptide involved in the pathogenesis of cardiovascular diseases associated with diabetes mellitus. We have previously reported that 5-lipoxygenase-derived products, particularly cysteinyl leukotrienes (CysLTs), are Ang II-induced contraction. In this study, we demonstrated CysLTs contribute to contraction elicited by isolated aortas from streptozotocin-induced diabetic (SS) rats but not insulin-treated rats, fructose-fed or control rats. an organ...
This study was undertaken to investigate the vascular actions (contraction and relaxation) of F2-isoprostane metabolites 15-keto-15-F2t-IsoP, 2,3-dinor-15-F2t-IsoP, 2,3-dinor-5,6-dihydro -15-F2t-IsoP in comparison with 15-F2t-IsoP on rat thoracic aorta. 15-keto-15-F2t-IsoP induced a vasoconstriction concentration-dependent manner pD2 value 5.80 ± 0.05, whereas 2,3-dinor-15-F2t-IsoP 2,3-dinor-5,6-dihydro-15-F2t-IsoP had no effect. The parent compound more potent (pD2 value: 6.46 0.1)....
Objectives We have previously reported that 5-lipoxygenase-derived products, and particularly the cysteinyl leukotrienes (CysLTs), were involved in angiotensin II (Ang II)-induced contractions isolated aortas from spontaneously hypertensive rats. Design The aim of this study was to assess role CysLTs vascular response Ang an II-dependent model hypertension, (mRen-2)27 transgenic rats (TGs). Methods Intact aortic rings TG normotensive Sprague–Dawley (SDs) suspended organ chambers for...
Long‐term treatment of rats with N ω ‐nitro‐ L ‐arginine methyl ester ( ‐NAME) induces hypertension associated inflammatory and vascular changes. Leukotrienes are proinflammatory vasoactive products that suspected to be involved in the pathogenesis hypertension. We investigated, chronically treated ‐NAME, involvement leukotrienes vivo regulation blood pressure vitro contraction elicited by noradrenaline isolated aorta. Rats were randomly assigned four groups orally for 3 weeks ‐NAME (1 mg ml...
Abstract Mixtures of polymers mesomorphic properties with mesogenic plasticizers were investigated by differential scanning calorimetry (DSC). The nature the structure could be identified studying concentration dependence such thermal processes as glass transition, mutual solution phases and formation eutectic melts. a supposed nematic poly(phenyl‐ p ‐acryloyloxy‐benzoate) (pPAB), poly( ‐butoxy‐phenyl‐ (pBPAB), ‐methoxy‐phenyl‐ ‐methacryloyloxy‐ethoxy‐benzoate) (pMPMEB), one copolymer...
Chronic treatment with Sandimmune (cyclosporine A [CsA] dissolved in Cremophor EL [CrEL]) is often associated hypertension and nephrotoxicity. The aims of the present study were to assess effect its two main components (CsA CrEL) on human saphenous veins underlying mechanism their contractile responses. In organ bath, concentration-response curves for (36 ng/ml-120 microg/ml CsA). CsA microg/ml), or CrEL (2.4 microg/ml-8 mg/ml) elicited presence a thromboxane A2 (TXA2) receptor antagonist...
<title>Abstract</title> <bold>Background </bold>: When the diagnosis of HAE is known in a family and child born, question early at birth arises. Indeed, first attacks may appear as birth. The importance comes up against biological issues: C1 Inhibitor (C1 INH) C4 levels can be low birth, generally range 60 to 100% adult reference values, due immaturity complement system. As most proteins, their normalize after one year life. We report opposite case, two newborns. <bold>Case...