A5002922004- Contact Dermatitis and Allergies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Mast cells and histamine
- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Psoriasis: Treatment and Pathogenesis
- Food Allergy and Anaphylaxis Research
- Botulinum Toxin and Related Neurological Disorders
- Dermatology and Skin Diseases
- Genital Health and Disease
- Allergic Rhinitis and Sensitization
- Cancer and Skin Lesions
- Systemic Lupus Erythematosus Research
- Autoimmune Bullous Skin Diseases
- Cutaneous Melanoma Detection and Management
- Sexual function and dysfunction studies
- Nail Diseases and Treatments
- Extracellular vesicles in disease
- Occupational exposure and asthma
- Cutaneous lymphoproliferative disorders research
- Pharmaceutical studies and practices
- Reproductive tract infections research
- Urologic and reproductive health conditions
- Nonmelanoma Skin Cancer Studies
- Vitamin K Research Studies
Université de franche-comté
2014-2025
Centre Hospitalier Universitaire de Besançon
2016-2025
Inserm
2011-2024
Agroécologie
2016-2023
Centre Hospitalier Universitaire de Martinique
2021
Sorbonne Université
2018
Assistance Publique – Hôpitaux de Paris
2018
Institute of Dermatology
2018
Laboratoire National de Référence
2018
Pitié-Salpêtrière Hospital
2018
Dermatofibrosarcoma protuberans (DFSP) is a rare malignant tumour of the skin, with an estimated incidence 0.8 to five cases per 1 million people year.To study epidemiological, immunohistochemical and clinical features, delay in diagnosis, type treatment outcome DFSP from 1982 2002.Using data population-based cancer registry, 66 patients pathologically proved were included (fibrosarcomatous excluded). Each patient lived one four departments Franche-Comté (overall population people) at time...
Genital psoriasis is often under-recognized.To assess the instantaneous prevalence of genital and describe its clinical features, association with a particular subtype impact on general sexual quality life (QoL).GENIPSO prospective study conducted by private hospital-based dermatologists. This featured consecutive inclusion patients consulting for extragenital psoriasis. The features were recorded QoL health questionnaires distributed to patients.Overall, 335 776 (43·2%) included in had...
BackgroundMastocytosis and monoclonal mast cell (MC) activation syndrome (MMAS) are heterogeneous conditions characterized by the accumulation of atypical MCs. Despite recurrent involvement KIT mutations, pathophysiologic origin mastocytosis MMAS is unclear. Although hereditary α-tryptasemia (HαT, related to TPSAB1 gene duplication) abnormally frequent in these diseases, it not known whether association coincidental or causal.ObjectiveWe evaluated prevalence HαT all subtypes assessed with...
Allergic contact dermatitis (ACD) to hair dyes is commonly caused by para-phenylenediamine (PPD) and related chemicals. We report three cases of ACD containing natural indigo. A 48-year-old woman presented with a scalp that occurred after the third use dye. She was patch tested using IQ chambers (Chemotechnique Diagnostics, Vellinge, Sweden) European baseline series, several supplemental including our hairstyling panel (25 hairstyling-associated allergens), plant (15 allergens) cosmetic (50...
Provoked vestibulodynia is difficult to treat. The beneficial effects of botulinum toxin A are being considered because the muscular anomalies observed in this pathology.To evaluate efficacy treatment provoked vestibulodynia.Patients aged between 18 and 60 years presenting with (according 2003 International Society for Study Vulvar Disease classification) received 50 U bilaterally bulbospongiosus muscle under electromyographic monitoring. Pain was evaluated by a visual analogue scale (VAS),...
Livedoid vasculopathy is a rare thrombotic cutaneous disease. This observational study aimed to assess the clinical and biological features of livedoid efficacy treatments. Patients enrolled had typical both clinically histologically. Investigation thrombophilia was performed. Electromyography undertaken in presence symptoms suggesting peripheral neuropathy. Eighteen women 8 men were included, with mean age 35.5 years at onset. Twenty patients least one factor. Ten neuropathy 2 these...
Background: Hereditary angioedema (HAE) is characterized by unpredictable and potentially life-threatening attacks of cutaneous submucosal swelling. Over the past decade, new agents, based on a better understanding underlying biologic mechanisms HAE, have changed face long-term prophylaxis (LTP). Objective: The objective was to describe current practices unmet needs with regard LTP for HAE in expert centers France. Methods: study conducted France 2020. Based their experience patients who had...
Angiogenesis has been reported as a parameter of potential prognostic value in solid tumours, it may facilitate tumour growth and metastasis. One the most important factors involved angiogenesis is vascular endothelial factor (VEGF).To determine predictive circulating VEGF levels cohort patients with melanoma.In prospective study, 324 cutaneous melanoma at different clinical stages were investigated over 2 years (2002-04). was measured plasma using enzyme-linked immunosorbent assay. Two...
Provoked vestibulodynia is a relatively common condition that affects sexual activity. Multidisciplinary care indicated and OnabotulinumtoxinA injections are safe effective treatment in this indication.To assess the long-term efficacy of provoked vestibulodynia.Twenty-one patients treated with (50U each bulbospongiosus muscle) 24 months prior to study were included. Data on pain [assessed using visual analogue scale (VAS)], quality life [measured by Dermatology Life Quality Index (DLQI)] sex...
Although primary cutaneous lymphomas (PCL) are the second most common group of extra-nodal non-Hodgkin lymphomas, few epidemiological data available in literature, and them provided by large databases from population-based cancer registries US or patients attending a single institution. We conducted this study to investigate clinical features PCL diagnosed département Doubs 1980 2003. Data were collected registry Seventy-one with investigated. 82% T-cell lymphoma (CTCL) 18% B-cell (CBCL)....
Background: Drug survival in a real-life setting is critical to long-term use of biologics for psoriasis.Objective: We describe our 12-year experience with psoriasis patients.Patients and Methods: All patients treated including infliximab, adalimumab (ADA), etanercept (ETA), ustekinumab (UST) vulgaris between January 2005 December 2016 were retrospectively analyzed.Results: In total, 545 treatment series administered 269 patients, 211 ADA, 135 ETA, 77 122 UST. ADA ETA initiated most often as...