Background— The primary objective of this mechanistic open-label, stratified clinical trial was to determine the effect 8 weeks’ sodium glucose cotransporter 2 inhibition with empagliflozin 25 mg QD on renal hyperfiltration in subjects type 1 diabetes mellitus (T1D). Methods and Results— Inulin (glomerular filtration rate; GFR) paraaminohippurate (effective plasma flow) clearances were measured individuals based having (T1D-H, GFR ≥ 135 mL/min/1.73m , n=27) or normal (T1D-N, 90–134 n=13) at...

Introduction: Acute severe ulcerative colitis (ASUC) is a serious complication affecting 9%–15% of patients with UC within 3 months diagnosis and up to 28% during the course disease. Despite use infliximab calcineurin inhibitors, rate colectomy remains high both hospitalization in 5 years after an acute episode. We present case ASUC that was unresponsive conventional therapies but successfully treated filgotinib. Case Presentation: A 21-year-old male recent presented our hospital flare. He...

Chronic Kidney Disease (CKD) is a pressing global health concern that placing increased strain on care resources. CKD patients regularly receive peritoneal dialysis as common treatment. An emerging technological solution telehomecare way to support receiving PD in their homes. This study protocol outlines mixed methods evaluation exploring developed enhance patients' outcomes and experiences. The aims assess the usability, acceptability scalability of this virtual application.A realist using...

Rationale: Recruitment in critical care research differs from other contexts important ways: patients lack decision-making capacity, uncertainty exists regarding patient prognosis, and illnesses are often associated with appreciable morbidity mortality.Objectives: We aimed to describe the experiences of surrogate decision makers (SDMs) being approached for consent critically ill participate research.Methods: A multicenter, qualitative study involving semistructured interviews 26 SDMs, who...

Inappropriate use of antimicrobials is linked to the development and spread drug-resistant pathogens associated with increased morbidity, mortality, lengths hospital stay, health care costs. "Antimicrobial stewardship" umbrella term for an evidence-based knowledge translation strategy involving comprehensive quality improvement activities optimize antimicrobials, improve patient outcomes, reduce antimicrobial resistance hospital-acquired infections such as Clostridium difficile, decrease...

People living with nephrotic syndrome (NS) need to develop an in-depth understanding of their condition in order participate treatment decisions, self-management skills and integrate illness into daily life. However, the learning needs adult patients parents children NS are unknown. We therefore explored patient parent perspectives on related as part a larger study shared tool for NS. Qualitative data were collected using semistructured focus groups individual interviews (n = 22) 25). The...

How service providers and users view near misses in their daily practice within the rubric of patient safety events is not well understood. Further no studies were located that explored specifically mental health settings Canada. In this context, a qualitative study was undertaken to gain insight into how (mental clients or family members) experienced defined misses. Eight (8) focus groups (n= 88) with 28 semi-structured interviews conducted at three care organizations. Content analysis...

Antimicrobial stewardship programs (ASPs) have predominately involved infectious diseases physicians and pharmacists with little attention to the nurses. To achieve optimal success of ASPs, engagement nurses actively participate in initiatives, strategies, solutions combat antibiotic resistance across health care spectrum is required. In this context, experiences local ASP teams engaging appropriate antimicrobial use were explored inform future strategies enhance their involvement ASPs.

The use of interorganizational, collaborative approaches to build capacity in quality improvement (QI) health care is showing promise as a useful model for scaling up and accelerating the implementation interventions that bridge "know-do" gap improve clinical provider outcomes. Fundamental approach interorganizational learning whereby organizations acquire, share, combine knowledge with other have opportunity learn from their respective successes challenges areas. This aims create conditions...

Organizational and professional efforts to support nurses engaging in research projects that advance patient safety practices are needed. In this context, the purpose of article is provide a description design, implementation, evaluation capacity strategy designed for clinical lessons learned. Participating evolved from novices key champions advancing nursing practice, safety, quality improvement.

This paper highlights the relationship between Fundamentals of Care Framework, patient safety and quality improvement by describing a more holistic view engagement across healthcare system.

Managers are uniquely placed to facilitate quality improvement (QI), yet little empirical evidence exists about their influence in engaging clinicians QI. To address this gap, a qualitative study was undertaken and revealed 2 themes: balancing being present with letting frontline staff lead QI projects, leveraging flexibility scheduling protected time. Efforts needed enable managers engage local efforts.

The purpose of this study was to elicit perceptions and experiences nurses associated with a recovery process (near miss) intervention (wound care management). From the content analysis interview data involving 12 registered nurses, 2 key themes emerged. Both illuminated links among pattern recognition, alignment processes practice guidelines, nurses' accountability for safe pressure ulcer care.

Engaging regulated health professionals in research is associated with greater service efficiencies and positive patient outcomes (reduced mortality morbidity). This paper provides the results from a study undertaken to explore perspectives experiences of nurses disciplines participating collaborative practice based (CPBR) capacity building educational program. The purpose this was perceptions other an interprofessional, strategy. interviews were analyzed using inductive, thematic analysis...

Managing patients with nephrotic syndrome (NS) remains difficult for the practicing nephrologist. This often young patient population is faced a debilitating, relapsing and remitting disease non-specific treatment options that are poorly tolerated. Clinicians managing these complex must attempt to apply disease-specific evidence while considering individual patient's clinical personal situation.We conducted qualitative interviews ascertain provider perspectives of NS, factors influence...

Background: Although there is a growing body of literature on the outcomes and impacts remote home management with peritoneal dialysis (PD) patients, less understood how this virtual care solution quality efficiency healthcare system care. In context, study was undertaken to understand perceptions patients their caregivers, providers, health decision makers, vendors associated monitoring tracking aimed at enhancing experiences chronic kidney disease (CKD) receiving PD home. Methods: A...

Abstract. The relationship between aesthetic and non-aesthetic properties is the subject of theoretical investigation by Jerrold Levinson Thomas Reid. According to Reid, are perceptual that inherent so-called natural signs require cognitive processing internally varied connected qualitative dimension mind. Reid also leans towards solution supervenience, but unlike Levinson, he places this against a background marked presence an agent consciousness. This justifies both interpretation...

Research Articles| March 24 2010 The Pressure-volume Relation in Tonometry Subject Area: Ophthalmology E. Mammarella; Mammarella From the Ophthalmological Clinic of University Sassari (Director: Prof. Dr. M. Maione) Search for other works by this author on: This Site PubMed Google Scholar Maione Ophthalmologica (1965) 149 (2): 81–85. https://doi.org/10.1159/000304734 Article history Published Online: Content Tools Views Icon contents Figures & tables Video Audio Supplementary Data Peer...

Early research in the area of virtual care solutions with peritoneal dialysis (PD) patients has focused on evaluating outcomes and impact these solutions. There been less attention understanding factors influencing uptake, usability, scalability for chronic kidney disease (CKD) receiving PD at home.In this context, a study was undertaken to (1) assess understand uptake solution (2) provide recommendations aimed enhancing CKD patients' experiences.This used qualitative design semistructured...

Although there is a body of literature around discipline specific capacity building research, less known empirically collaborative practice-based research that involves different healthcare disciplines participating in together an interprofessional manner Academic Health Science Centers (AHSCs). This paper provides overview results from the mixed methods study and subsequent strategies one teaching hospital has implemented to enhance research. A design with cross-sectional survey focus...

A qualitative study was undertaken to explore the experiences and perceptions of project leaders, clinicians, managers, mentors associated with implementation a strategy aimed at enhancing clinicians' ability use data guide quality improvement projects. Our findings elucidated value benefits including (1) using understand local context move forward (2) improving care engaging in collaborative professional practice.

There are promising signs that interprofessional collaborative practice is associated with quality care transitions and improved access to patient-centred healthcare. A one-day symposium was held increase awareness capacity deliver health disciplines service users.