A5022663900- Neurogenesis and neuroplasticity mechanisms
- Pluripotent Stem Cells Research
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- T-cell and Retrovirus Studies
- Neurological Disorders and Treatments
- Mesenchymal stem cell research
- Developmental Biology and Gene Regulation
- Congenital heart defects research
- Biochemical Acid Research Studies
- Carcinogens and Genotoxicity Assessment
- Neuroinflammation and Neurodegeneration Mechanisms
- Aluminum toxicity and tolerance in plants and animals
- Mycotoxins in Agriculture and Food
- GDF15 and Related Biomarkers
- interferon and immune responses
- Transgenic Plants and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- SARS-CoV-2 and COVID-19 Research
- Genetic and Kidney Cyst Diseases
- Computational Drug Discovery Methods
- TGF-β signaling in diseases
- CRISPR and Genetic Engineering
- Liver physiology and pathology
- Epigenetics and DNA Methylation
Inserm
2018-2023
Fondation pour la Recherche Médicale
2021-2023
Université Claude Bernard Lyon 1
2019-2023
Centre National de la Recherche Scientifique
2018-2023
Centre International de Recherche en Infectiologie
2019-2023
École Normale Supérieure de Lyon
2019-2023
Institut du Cerveau
2018-2021
Assistance Publique – Hôpitaux de Paris
2021
Sorbonne Université
2018-2021
Sorbonne Paris Cité
2019
Quiescence is essential for the long-term maintenance of adult stem cells but how maintain quiescence poorly understood. Here, we show that neural (NSCs) in mouse hippocampus actively transcribe pro-activation factor Ascl1 regardless their activated or quiescent states. We found inhibitor DNA binding protein Id4 enriched NSCs and elimination results abnormal accumulation premature cell activation. Accordingly, other Id proteins promote NSC cultures. sequesters heterodimerization partner E47,...
Anamniotes, rodents, and young humans maintain neural stem cells in the ependymal zone (EZ) around central canal of spinal cord, representing a possible endogenous source for repair mammalian lesions. Cell diversity genes specific this region are ill defined. A cellular molecular resource is provided here mouse human EZ based on RNA profiling, immunostaining, fluorescent transgenic mice. This uncovered conserved expression 1,200 including 120 transcription factors. Unexpectedly maintains an...
Abstract Ochratoxin A (OTA), a mycotoxin that was discovered as secondary metabolite of the fungal species Aspergillus and Penicillium , is common contaminant in food animal feed. This has been described teratogenic, carcinogenic, genotoxic, immunotoxic proven potent neurotoxin. Other authors have previously reported effects OTA different structures central nervous system well some neurogenic regions. However, impact exposure subventricular zone (SVZ) not assessed yet. To elucidate whether...
After trauma brain injury, oxidative substances released to the medium provoke an enlargement of initial lesion, increasing glial cell activation and, occasionally, influx immune cells into central nervous system, developing secondary damage. In response these stimuli, microglia are activated perform upregulation intracellular enzymes and surface markers propagate phagocytosis cellular debris. The debris dead is essential limit inflammatory reaction potentially prevent extension damage...
SUMMARY Quiescence is essential for the long-term maintenance of adult stem cells and tissue homeostasis. However, how maintain quiescence still poorly understood. Here we show that in dentate gyrus hippocampus actively transcribe pro-activation factor Ascl1 regardless their activation state. We found inhibitor DNA binding protein Id4 suppresses activity neural cell cultures. sequesters heterodimerisation partner E47, promoting degradation quiescence. Accordingly, elimination from results...
The Human T-cell Leukemia Virus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a devastating neurodegenerative disease with no effective treatment, which affects an increasing number of people in Brazil. Immune cells from the adaptive compartment are involved manifestation but whether innate cell functions participate occurrence has not been evaluated. In this study, we analyzed responses at steady state and after blood stimulation using agonist toll-like receptor...
Ependymal cells are radial glia-derived multiciliated lining the lateral ventricles of brain and spinal cord. Correct development coordinated cilia beating is essential for proper cerebrospinal fluid (CSF) flow neurogenesis modulation. Dysfunctions ependymal were associated with transcription factor deregulation. Here we provide evidence that transcriptional regulator ID4 involved in cell maturation. We observed Id4 -deficient mice display altered ventricular cytoarchitecture, decreased...
Primary objective: The aim of this study was to investigate the reparative potential a polymeric scaffold designed for brain tissue repair in combination with lipoic acid.Research design: Histological, cytological and structural analysis combined treatment after cryo-injury model rats.Methods procedures: Adult Wistar rats were subjected cryogenic injury. A channelled-porous ethyl acrylate hydroxyethylacrylate, p(EA-co-HEA) grafted into cerebral penumbra alone or intraperitoneal LA...
The human T-cell leukemia virus (HTLV)-1 is responsible for an aggressive neurodegenerative disease (HAM/TSP) and multiple neurological alterations. capacity of HTLV-1 to infect central nervous system (CNS) resident cells, together with the neuroimmune-driven response, has not been well-established. Here, we combined use induced pluripotent stem cells (hiPSC) naturally STLV-1-infected nonhuman primates (NHP) as models which investigate neurotropism. Hence, neuronal obtained after hiPSC...
Quiescence is essential for the long-term maintenance of adult stem cells and tissue homeostasis. However, how maintain quiescence still poorly understood. Here we show that in dentate gyrus hippocampus actively transcribe pro-activation factor Ascl1 regardless their activation state. We found inhibitor DNA binding protein Id4 suppresses activity neural cell cultures. sequesters heterodimerisation partner E47, promoting degradation quiescence. Accordingly, elimination from results abnormal...
Abstract The Human T-cell Leukemia Virus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a devastating neurodegenerative disease with no effective treatment, which affects an increasing number of people in Brazil. A biological blood factor allowing the prediction occurrence so far not available. In this study, we analyzed innate immunity responses at steady state and after cell stimulation using agonist toll-like receptor (TLR)7/8-signaling pathway samples from...
Abstract Ependymal cells are radial glia-derived multiciliated lining the lateral ventricles of brain and spinal cord. Correct development coordinated cilia beating is essential for proper cerebrospinal fluid flow (CSF) neurogenesis modulation. Dysfunctions ependymal were associated with transcription factor deregulation. Here we provide evidence that transcriptional regulator Id4 involved in cell maturation. We observed -deficient mice display altered cytoarchitecture, decreased number, CSF...