A5082313254- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Advanced Nanomaterials in Catalysis
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Sulfur Compounds in Biology
- Photodynamic Therapy Research Studies
- Ocular Diseases and Behçet’s Syndrome
- Inflammasome and immune disorders
- Advanced biosensing and bioanalysis techniques
- Optical Imaging and Spectroscopy Techniques
- Wound Healing and Treatments
- Environmental Chemistry and Analysis
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Antimicrobial Peptides and Activities
- Spectroscopy Techniques in Biomedical and Chemical Research
- 3D Printing in Biomedical Research
- Heme Oxygenase-1 and Carbon Monoxide
- Analytical Chemistry and Sensors
- Extracellular vesicles in disease
- Advanced Photocatalysis Techniques
- Advancements in Transdermal Drug Delivery
- Carbon and Quantum Dots Applications
- Alcohol Consumption and Health Effects
South China University of Technology
2010-2024
State Key Laboratory of Luminescent Materials and Devices
2016-2024
Key Laboratory of Guangdong Province
2020
Materials Science & Engineering
2019-2020
Bioscience (China)
2010
An activatable nanoprobe for imaging breast cancer metastases through near infrared-I (NIR-I)/NIR-II fluorescence and multispectral optoacoustic tomography (MSOT) was designed. With a dihydroxanthene moiety serving as the electron donor, quinolinium acceptor nitrobenzyloxydiphenylamino recognition element, probe can specifically respond to nitroreductase transform into an activated D-π-A structure with NIR emission band extending beyond 900 nm. The exhibits enhanced by aggregation-induced...
Optoacoustic tomography (photoacoustic tomography) is an emerging imaging technology displaying great potential for medical diagnosis and preclinical research. Rationally designing activatable optoacoustic probes capable of diagnosing diseases locating their foci can bring into full play the role (OAT) as a promising noninvasive modality. Here we report two xanthene-based (C1X-OR1 C2X-OR2) temporospatial hepatic alkaline phosphatase (or β-galactosidase) evaluating drug-induced liver injury...
Acute kidney injuries (AKI) have serious short-term or long-term complications with high morbidity and mortality rate, thus posing great health threats. Developing high-performance NIR-II probes for noninvasive in situ detection of AKI via fluorescent optoacoustic dual-mode imaging is significance. Yet chromophores often feature long conjugation hydrophobicity, which prevent them from being renal clearable, limiting their applications the diseases. To fully exploit advantageous features...
Abstract Organic small-molecule contrast agents have attracted considerable attention in the field of multispectral optoacoustic imaging, but their weak performance resulted from relatively low extinction coefficient and poor water solubility restrains widespread applications. Herein, we address these limitations by constructing supramolecular assemblies based on cucurbit[8]uril (CB[8]). Two dixanthene-based chromophores (DXP DXBTZ) are synthesized as model guest compounds, then included...
Metformin is currently the most prescribed oral agent for diabetes treatment; however overdose or long-term use may cause some severe side effects such as liver injury.Researches indicate that metformin-induced injury closely related to upregulation of hepatic H 2 S. Hence, monitoring S generation induced by metformin could be an effective approach evaluating hepatoxicity drug.Methods: We present a novel turn-on and dual-mode probe detecting imaging specifically tracking with fluorescent...
The first AIE-probe based paper-strip sensor for rapid and point-of-use fluorescence detection of a gaseous nerve agent mimic has been developed.
The precise location of tumor and completeness surgical resection are critical to successful surgery; thus, the method capable preoperatively locating a site intraoperatively determining margins would be highly ideal. Herein, an activatable nanocomposite probe was developed for orthotopic hepatic via multispectral optoacoustic tomography imaging intraoperative navigation near-IR-1 (NIR-I) NIR-II fluorescence imaging. molecular comprises electronic donor, acceptor, recognition moiety forms...
Abstract Whilte herbal medicines are widely used for health promotion and therapy chronic conditions, inappropriate use of them may cause adverse effects like liver injury, accurately evaluating their hepatotoxicity is great significance public health. Herein, an activatable probe QY‐N diagnosing herbal‐medicine‐induced injury by detecting hepatic NO with NIR‐II fluorescence multispectral optoacoustic tomography (MSOT) imaging demonstrated. The includes a bismethoxyphenyl‐amine‐containing...
Abstract Sudden hemorrhage stemming from internal organ wounds poses a grave and potentially fatal risk if left untreated. Injectable‐hydrogel‐based tissue sealants featuring multiple actions, including fit‐to‐shape in situ gelation, rapid hemostasis, pro‐angiogenic, anti‐bacterial outcome tracking, are ideal for the management of trauma wounds. Herein, an injectable‐hydrogel sealant AN@CD‐PEG&TQ which consists four‐arm 4‐arm poly(ethylene glycol) (PEG‐SC) succinimidyl carbonate), AN@CD...
Abstract Lymphatic metastasis of tumor is one leading causes cancer‐related death, and diagnosing lymphatic significance in terms optimal disease management possible better outcomes for patients. Herein a turn‐on optoacoustic nanoprobe reported noninvasively locating vivo. A positively charged tricyanofuran‐containing polyene chromophore (TCHM) with high extinction coefficient designed, synthesized, allowed to form the negatively hyaluronan. The TCHMs take an aggregated state within exhibit...
Abstract Ulcerative colitis (UC) is a prevalent idiopathic inflammatory disease which causes such complications as intestinal perforation, obstruction, and bleeding, thus deleteriously impacting people's normal work quality of life. Hence, accurate diagnosis UC crucial in terms planning optimal treatment plan. Herein, pH/reactive oxygen species (ROS) dual‐responsive nanosystem (BM@EP) developed for UC's detection therapy. BM@EP composed chromophore‐drug dyad the enteric coating. The...
Wounds infected with bacteria, if left untreated, have the potential to escalate into life-threatening conditions, such as sepsis, which is characterized by widespread inflammation and organ damage. A comprehensive approach treating bacterial-infected wounds, encompassing control of bacterial infection, biofilm eradication, regulation, holds significant importance. Herein, a microneedle (MN) patch (FM@ST MN) has been developed, silk fibroin (SF) tannic acid-based hydrogel serving matrix....
Abstract An activatable nanoprobe for imaging breast cancer metastases through near infrared‐I (NIR‐I)/NIR‐II fluorescence and multispectral optoacoustic tomography (MSOT) was designed. With a dihydroxanthene moiety serving as the electron donor, quinolinium acceptor nitrobenzyloxydiphenylamino recognition element, probe can specifically respond to nitroreductase transform into an activated D‐π‐A structure with NIR emission band extending beyond 900 nm. The exhibits enhanced by...
An AIE-based fluorescent probe was developed for monitoring food spoilage<italic>via</italic>its response toward hydrogen sulfide.
An activatable probe has been developed for imaging alcoholic liver injury through detecting the overexpressed cytochrome p450 (cyp450) reductase in hypoxia hepatic region.
An NO-responsive probe for imaging acute inflammation was developed. The responds to in situ NO sites such as LPS-induced dermatitis and MIA-induced joint with turn-on NIR-II fluorescence optoacoustic signals.
Herbal medicines are widely used around the world, while some of them associated with adverse effects like herb-induced liver injury due to oxidative/nitrosative stress resulted from hepatically-generated ROS/RNS. It is significance accurately evaluate herbal-medicine-induced hepatotoxicity, since it would help provide effective monitoring method safety herbal remedies. Herein we designed a ratiometric nanoprobe for in vivo imaging hepatic induced by medicine (polygonum multiflorum, PM) via...
Developing high-quality dyes to construct activatable probes for analyte sensing via NIR-II fluorescence is critical attaining enhanced imaging depths and resolution. Heptamethine cyanines can serve this purpose; however, they usually have poor stability a tendency self-aggregate. Herein, we present design strategy involving the installation of pyridinium tert-butyl groups onto central cyclohexenyl core increase steric crowding, enhance water solubility, provide site incorporation...
Optoacoustic imaging has great potential for preclinical research and clinical practice, designing robust activatable optoacoustic probes specific diseases is beneficial its further development. Herein, an probe been developed tumor hypoxia imaging. For this probe, indole quinoline were linked on each side of oxocyclobutenolate core to form unsymmetrical squaraine. A triarylamine group was incorporated endow the molecule with aggregation enhanced emission (AEE) properties. In aqueous media,...
Abstract Inflammatory diseases are sometimes devastating and notoriously difficult to treat. Precisely modulating inflammatory signaling pathways is a promising approach for treating diseases. Herein, multifunctional nanosystem developed active targeting, activatable imaging on‐demand therapy against through pathways. A chromophore‐drug dyad (QBS‐FIS) synthesized by linking chromophore Nrf2 (nuclear factor E2‐related factor) activator fisetin boronate bond which serves as fluorescence...