A5000862370- Mitochondrial Function and Pathology
- Ocular Diseases and Behçet’s Syndrome
- Cerebrospinal fluid and hydrocephalus
- Nuclear Receptors and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Pain Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Circadian rhythm and melatonin
- RNA regulation and disease
- Multiple Sclerosis Research Studies
- Inflammasome and immune disorders
- Systemic Sclerosis and Related Diseases
- Liver Disease Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Ion Channels and Receptors
- Child and Adolescent Psychosocial and Emotional Development
- Trigeminal Neuralgia and Treatments
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- Dermatological and Skeletal Disorders
- Fetal and Pediatric Neurological Disorders
- Management of metastatic bone disease
- Neuroscience and Neuropharmacology Research
- Virology and Viral Diseases
- Fibroblast Growth Factor Research
First Affiliated Hospital of Zhengzhou University
2014-2025
Capital Normal University
2025
Nankai University
2021-2024
First Affiliated Hospital of Nanchang University
2015-2022
Nanchang University
2012-2022
South China University of Technology
2021
State Key Laboratory of Luminescent Materials and Devices
2021
Second Affiliated Hospital of Jilin University
2019
Jilin University
2018
The University of Texas Health Science Center at Houston
2016-2017
Abstract Whilte herbal medicines are widely used for health promotion and therapy chronic conditions, inappropriate use of them may cause adverse effects like liver injury, accurately evaluating their hepatotoxicity is great significance public health. Herein, an activatable probe QY‐N diagnosing herbal‐medicine‐induced injury by detecting hepatic NO with NIR‐II fluorescence multispectral optoacoustic tomography (MSOT) imaging demonstrated. The includes a bismethoxyphenyl‐amine‐containing...
Abstract Background We investigated the long-term effects and safety of botulinum toxin-A (BTX-A) for treating trigeminal neuralgia (TN). also studied maintenance this therapeutic effect. Methods A visual analog scale (VAS) score, pain attack frequency per day, patient’s overall response to treatment side during 14-month follow-up were evaluated in 88 patients with TN receiving BTX-A. The primary endpoints severity (assessed by VAS) day. secondary endpoint was treatment, assessed using...
This study explored the effects of mammalian target rapamycin (mTOR) on increased risk developing Alzheimer's disease (AD) in rats with type 2 diabetes mellitus (T2DM). Male Sprague-Dawley were randomly divided into four groups: control, T2DM, AD and T2DM+AD. Changes learning memory abilities observed using Morris water maze. mTOR activity tau protein hyperphosphorylation hippocampus analyzed by immunohistochemical staining RT-PCR. The experimental weakened compared those control group....
Background. Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) syndrome is an unusual cause of headache, mainly described in older adults, rare children. Pain attacks may be severe, frequent, prolonged. The therapeutic benefits many drugs are disappointing. Patient Methods. A 12-year-old boy suffered severe toothache for 20 days. As treatment nonsteroidal anti-inflammatory drugs, anticonvulsants, steroids proved ineffective, he was treated...
Arachidonic acid (AA) has potent pro-apoptotic effects on cancer cells at a low concentration and macrophages very high concentration. However, the of AA macrophage cell cycle related signaling pathways have not been fully investigated. Herein we aim to observe effect cycle.AA exposure reduced viability number in dose- time-dependent manner. The reduction RAW264.7 was caused by apoptosis, as indicated caspase-3 activated detection. Further research illustrated that induced arrested S phase,...
Purpose: Although retinoblastoma is rare but can be deadly in some severe cases. To find novel therapeutic targets for retinoblastoma, we explored the potential role of lncRNA NKILA retinoblastoma. Results: We found that, comparing to healthy controls, was downregulated, while XIST upregulated plasma patients and they were inversely correlated. Downregulation distinguished early-stage from controls. Overexpression mediated downregulation cells, overexpression failed significantly affect...
Abstract The central nervous system has long been thought to lack a clearance similar the peripheral lymphatic system. Therefore, of metabolic waste in subject great interest neuroscience. Recently, cerebral drainage system, including parenchymal and meningeal network, attracted considerable attention. It extensively studied various neurological disorders. Solute accumulation neuroinflammation after epilepsy impair blood–brain barrier, affecting exchange between cerebrospinal fluid...
The expression and significance of tyrosine hydroxylase (TH) in brain tissue rats with Parkinson's disease (PD) were explored analyzed. A total 120 clean‑grade healthy adult Wistar weighing 180-240 g randomly divided equally into four groups according to the random number table method. Rats sacrificed before after model establishment for 3, 6 or 8 weeks. revolutions was observed relative TH mRNA measured. left right normal respectively 1.039±0.112 0.956±0.120. There no significant difference...
This study aimed to explore the effects of elevated KDM4D expression and potential therapeutic Lycium barbarum polysaccharide (LBP) on pterygium.
Members of the transient receptor potential canonical (TRPC) protein family are widely distributed in hippocampus mammals and exert respective cooperative influences on functions neurons. The relationship between specific TRPC subtypes neuroinflammation is receiving increasing attention.Using Cx3cr1CreERIL-10-/- transgenic mice their littermates to study channels memory impairment.We demonstrated that displayed spatial deficits object location recognition (OLR) Morris water maze (MWM) tasks....
The possibility of extracting RNA and measuring expression from paraffin sections can allow extensive investigations on stored samples obtained diseased livers could help with studies the natural history liver fibrosis inflammation, in particular, correlate basic mechanisms to clinical outcomes.To address this issue, a pilot study multiplex gene using branched-chain DNA technology was conducted directly measure mRNA formalin-fixed paraffin-embedded needle biopsy human liver. Twenty-five...
The dysregulation of microRNAs (miRNAs/miRs) has become increasingly recognized as a primary feature retinoblastoma (RB). Furthermore, miRNAs have been demonstrated to be involved in the occurrence and development RB. Therefore, it is crucial investigate expression profile roles RB order identify potential therapeutic targets treat patients with biological miRNA‑504 (miR‑504) reported numerous types human cancer; however, miR‑504 remain unknown. In present study, was that significantly...
Abstract The pathogenesis of systemic lupus erythematosus (SLE) is closely associated with aberrant immune system. Here, the aim our study was to explore regulation cucurbitacin IIb (CuIIb) Th17/Treg cells in SLE. Compared normal mice, percentage Treg downregulated SLE mouse model, and Th17 upregulated. Meantime, production Treg‐related transcription factor (foxp3) model reduced, Th17‐related (RORγt) increased. After treatment CuIIb, mice partly upregulated, downregulated. expression foxp3...
Immune-mediated inflammatory diseases (IMIDs) represent a diverse group of and challenges remain for the current medications. Herein, we present an activatable targeted nanosystem detecting imaging IMIDs foci treating them through blocking NF-κB/NLRP3 pathways. A ROS-activatable prodrug BH-EGCG is synthesized by coupling near-infrared chromophore with inhibitor epigallocatechin-3-gallate (EGCG) boronate bond which serves as both fluorescence quencher ROS-responsive moiety. molecules readily...
Abstract Aim Previous research has shown that adiponectin ( AD ) induces severe insulin resistance IR and exhibits pro‐inflammatory effect, so it could serve as a useful risk biomarker in rheumatoid arthritis RA ). The present study aims to evaluate the effect of on anti‐arthritis collagen‐induced arthritic CIA rats. Method After immunization with bovine type II collagen CII ), Wistar rats were administered (60 μg/kg/day) or saline into ankle joint cavity left hind leg for 15 days. severity...